Publications

2024

Brynzak-Schreiber E, Schögl E, Bapp C, Cseh K, Kopatz V, Jakupec MA, Weber A, Lange T, Toca-Herrera JL, del Favero G, Wadsak W, Kenner L, Pichler V (2024) Microplastics Role in Cell Migration and Distribution During Cancer Cell Division. Chemosphere; 353:141463

Cumin C, Gee L, Litfin T, Muchabaiwa R, Martin G, Cooper O, Heinzelmann-Schwarz V, Lange T, von Itzstein M, Jacob F, Everest-Dass A (2024) Highly sensitive spatial glycomics at near-cellular resolution by on-slide derivatization and mass spectrometry imaging. Analytical Chemistry; 96: 11163-171

Staffeldt L, Maar H, Beimdiek J, Chamber S, Riecken K, von Itzstein M, Büttner FFR, Everest-Dass A, Lange T (2024) Depletion of β1,6-N-acetylglucosaminyltransferase reduces E-selectin binding capacity and migratory potential of human gastrointestinal adenocarcinoma cells. Neoplasia (accepted)

Gorodetska I, Offermann A, Püschel J, Lukiyanchuk V, Gaete D, Kurzyukova A, Freytag V, Haider MT, Fjeldbo CS, Di Gaetano S, Schwarz FM, Patil S, Borkowetz A, Erb H, Baniahmad A, Mircetic J, Lyng H, Lock S, Linge A, Lange T, Knopf F, Wielockx B, Krause M, Perner S, Dubrovska A (2023) ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription. Theranostics; 14:714-37.              

Haider MT, Freytag V, Krause L, Spethmann T, Gosau T, Beine MC, Knies C, Schröder-Schwarz J, Horn M, Riecken K, Lange T (2024) Comparison of ex vivo bioluminescence imaging, Au-qPCR and histology for the quantification of spontaneous lung and bone metastases in subcutaneous xenograft mouse models. Clin Exp Metastasis 41:103-15 

Everest-Dass A, Nersisyan S, Maar H, Novosad V, Schröder-Schwarz J, Freytag V, Stuke JL, Beine MC, Schiecke A, Haider MT, Kriegs M, Elakad O, Bohnenberger H, Conradi L, Raygorodskaya M, Krause L, von Itzstein M, Tonevitsky A, Schumacher U, Maltseva D, Wicklein D, Lange T (2024). Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer. Mol Oncol; 18:62-90.

2023

Starzonek S, Maar H, Mereiter S, Freytag V, Haider MT, Riecken K, Huang YL, Jacob F, Wicklein D, Schumacher U, Lange T (2023) Identification of potential classes of glycoligands mediating dynamic endothelial adhesion of human tumor cells. Glycobiology; "33:637-650."

Kerner AM, Biedermann U, Bräuer L, Caspers S, Doll S, Engelhardt M, Filler TJ, Ghebremedhin E, Gundlach S, Hayn-Leichsenring GU, Heermann S, Hettwer-Steeger I, Hiepe L, Hirt B, Hirtler L, Hörmann R, Kulisch C, Lange T, Leube R, Meuser AH, Müller-Gerbl M, Nassenstein C, Neckel PH, Nimtschke U, Paulsen F, Prescher A, Pretterklieber M, Schliwa S, Schmidt K, Schmiedl A, Schomerus C, Schulze-Tanzil G, Schumacher U, Schumann S, Spindler V, Streicher J, Tschernig T, Unverzagt A, Valentiner U, Viebahn C, Wedel T, Weigner J, Weninger W, Westermann J, Weyers I, Waschke J, Hammer N (2023) The chemicals between us - First results of the cluster analyses on anatomy embalming procedures in the German-speaking countries. Anat Sci Educ; "16:814-829."

Giannou A, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Vesely ACM, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovestka D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, Sabihi M, Huber FJ, Reeh M, Grass JK, Wahib R, Seese H, Stüben BO, Fard-Aghaie M, Dupree A, Scognamiglio P, Plitzko G, Meiners J, Soukou S, Wittek A, Manthey C, Maroulis IC, Arck PC, Perez D, Gao B, Zarogiannis SG, Strowig T, Pasqualini R, Arap W, Suarez Gosalvez J, Kobold S, Prinz I, Guse AH, Tachezy M, Ghadban T, Heumann A, Li J, Melling N, Mann O, Izbicki JR, Pantel K, Schumacher U, Lohse AW, Flavell RA, Gagliani N, Huber S (2023) Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via Interleukin-22. Immunity; 56:125-42.e12.

Klusa D, Lohaus F, Franken A, Baumbach M, Cojoc M, Dowling P, Linge A, Offermann A, Löck S, Husman D, Rivandi M, Polzer B, Labitzky V, Lange T, Neubauer H, Kuecken M, Perner S, Hölscher T, Krause M, Kurth I, Dubrovska A, Baumann M, Peitzsch C (2023) Dynamics of CXCR4 positive circulating tumor cells in prostate cancer patients during radiotherapy. Int J Cancer; "152:2639-2654."

Schäfer P, Muhs S, Turnbull L, Garwal P, Maar H, Yorgan TA, Tolosa E, Lange T, Windhorst S (2023) Ex vivo model of neuroblastoma plasticity. Cancers (Basel); 15: 1274.

Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C, Milde-Langosch K, Oliveira-Ferrer L, Ricklefs FL, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnenberger H, Offermann A, Perner S, Sebens S, Lamszus K,  Diehl L, Linder S, Jücker M, Schumacher U, Lange T (2023) Tumor Cell Integrin β4 and Tumor Stroma E-/P-Selectin Cooperatively Regulate Tumor Growth in vivo. J Hematol Oncol; 16: 23.

Böckelmann LC, Freytag V, Ahlers AK, Maar H, Gosau T, Baranowsky A, Schmitz R, Pantel K, Schumacher U, Lange T (2023) Efficacy of zoledronic acid for the elimination of disseminated tumor cells in a clinically relevant, spontaneously metastatic prostate cancer xenograft model. Bone; 171: 116741.

2022

Oh-Hohenhorst SJ, Tilki D, Ahlers AK, Suling A, Hahn O, Tennstedt P, Matuszcak C, Maar H, Labitzky V, Hanika S, Starzonek S, Baumgart S, Johnsen SA, Kluth M, Sirma H, Simon R, Sauter G, Huland H, Schumacher U, Lange T (2022) CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo. Cancer Gene Ther; 29:49-61.

Nersisyan S, Ahlers AK, Lange T, Wicklein D, Galatenko A, Bohnenberger H, Elakad O, Conradi LC, Genduso S, Maar H, Schiecke A, Maltseva D, Raygorodskaya M, Makarova J, Schumacher U, Tonevitsky A (2022) Low expression of CD24 is associated with poor survival in colorectal cancer. Biochimie; 192:91-101.

Lange T, Valentiner U, Wicklein D, Maar H, Labitzky V, Ahlers AK, Starzonek S, Genduso S, Staffeldt L, Pahlow C, Dück AM, Stürken C, Baranowsky A, Bauer AT, Bulk E, Schwab A, Riecken K, Börnchen C, Kiefmann R, Abraham V, DeLisser HM, Gemoll T, Habermann JK, Block A, Pantel K, Schumacher U (2022) Tumor cell E-selectin ligands determine partial efficacy of bortezomib on spontaneous lung metastasis formation of solid human tumors in vivo. Mol Ther; 30:1536-52          .

Wang Y, Liu X, Obser T, Bauer AT, Heyes M, Starzonek S, Zulal M, Opitz K, Ott L, Riethdorf S, Lange T, Pantel K, Bendas G, Schneider SW, Kusche-Gullberg M, Gorzelanny C (2022) Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis. Matrix Biol; 111:76-94.

Elakad O, Häupl B, Labitzky V, Yao S, Küffer S, von Hammerstein-Equord A, Danner BC, Jücker M, Urlaub H, Lange T, Ströbel P, Oellerich T, Bohnenberger H (2022) Activation of CD44 / PAK1 / AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer. NPJ Precis Oncol; 6:52.

Freytag V, Valentiner U, Lange T (2022) Detection of spontaneous bone metastases of solid human tumor xenografts in mice. Methods Mol Biol; 2524:317-25.

2021

Baranowsky A, Appelt J, Kleber C, Lange T, Ludewig P, Jahn D, Pandey P, Keller D, Rose T, Schetler D, Braumüller S, Huber-Lang M, Tsitsilonis S, Yorgan T, Frosch K-H, Amling M, Schinke T, Keller J (2021) Procalcitonin exerts a mediator role in septic shock through the calcitonin gene-related peptide receptor. Crit Care Med; 49: e41-e52.

Spethmann T, Böckelmann LC, Labitzky V, Ahlers AK, Schröder-Schwarz J, Bonk S, Simon R, Sauter G, Huland H, Kypta R, Schumacher U, Lange T (2021) Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets. Mol Oncol; 15:1956-69.

Hinz N, Baranowsky A, Horn M, Kriegs M, Sibbertsen F, Smit DJ, Clezardin P, Lange T, Schinke T, Jücker M (2021) Knockdown of AKT3 activates HER2 and DDR kinases in bone-seeking breast cancer cells, promotes metastasis in vivo and attenuates the TGFβ/CTGF axis. Cells; 10:430.

Kemper M, Schiecke A, Maar H, Nikulin S, Poloznikov A, Galatenko V, Tachezy M, Gebauer F, Lange T, Riecken K, Tonevitsky A, Aigner A, Izbicki J, Schumacher U, Wicklein D (2021) Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression. J Exp Clin Canc Res; 40:214.

Bußmann L, Hoffer K, von Bargen C, Droste C, Lange T, Kemmling J, Schröder-Schwarz J, Vu A, Akingunsade L, Nollau P, Rangarajan S, de Wijn R, Oetting A, Müller C, Böckelmann L, Zech H, Berger J, Möckelmann N, Busch C-J, Boettcher A, Gatzemeier F, Klinghammer K, Simnica D, Binder M, Struve N, Rieckmann T, Schumacher U, Clauditz T, Betz C, Petersen C, Rothkamm K, Münscher A, Kriegs M (2021) Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src-family kinases as prognostic markers and potential targets. Int J Cancer; 149:1166-80.

Mukha A, Kahya U, Linge A, Chen O, Löck S, Lukiyanchuk V, Richter S, Alves TC, Peitzsch M, Telychko V, Skvortsov S, Negro G, Aschenbrenner B, Skvortsova I, Mirtschink P, Lohaus F, Hölscher T, Neubauer H, Rivandi M, Labitzky V, Lange T, Franken A, Behrens B, Stoecklein NH, Toma M, Sommer U, Zschaeck S, Rehm M, Eisenhofer G, Schwager C, Abdollahi A, Groeben C, Kunz-Schughart LA, Baretton GB, Baumann M, Krause M, Peitzsch C, Dubrovska A (2021) GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy. Theranostics; 11:7844-68.

Huang YL, Liang CY, Labitzky V, Ritz D, Oliveira T, Cumin C, Estermann M, Lange T, Everest-Dass AV, Jacob F (2021) Site-specific N-glycosylation of integrin alpha 2 mediates collagen-dependent cell survival. iScience; 24:103168.

2020

Labitzky V, Baranowsky A, Maar H, Hanika S, Starzonek S, Ahlers AK, Stübke K, Koziolek EJ, Heine M, Schäfer P, Windhorst S, Jücker M, Riecken K, Amling M, Schinke T, Schumacher U, Valentiner U, Lange T (2020) Modeling spontaneous bone metastasis of solid human tumor xenografts in mice. Cancers (Basel); 12: 385.

Starzonek S, Maar H, Labitzky V, Wicklein D, Rossdam C, Buettner FFR, Wolters-Eisfeld G, Guengoer C, Wagener C, Schumacher U, Lange T (2020) Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions. Glycobiology; 30: 695-709.

Hoffmann B, Lange T, Labitzky V, Riecken K, Wree A, Schumacher U, Wedemann G (2020) The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments. BMC Cancer; 20: 524.

Maire C, Mohme M, Bockmayr M, Fita K, Riecken K, Boernigen D, Alawi M, Failla AV, Neumann K, Dührsen L, Lange T, Kolbe K, Zapf S, Holz M, Fehse B, Westphal M, Lasmzus K (2020) Glioma escape signature and clonal development under immune pressure. J Clin Invest; 130: 5257-71.

Lange T, Samatov TR, Galatenko VV, Steffen P, von Kriegstein H, Spethmann T, Wicklein D, Maar H, Kupfernagel K, Labitzky V, Hanika S, Starzonek S, Ahlers A-K, Riecken K, Simon R, Polonski A, Sauter G, Schlomm T, Huland H, Johnsen SA, Schlüter H, Tonevitsky AG, Schumacher U (2020) Xenograft-derived mRNA/miR and protein interaction networks of systemic dissemination in human prostate cancer. Eur J Cancer; 137:93-107.