Publikationen

Lucchetti M, Aina KO, Grandmougin L, Jäger C, Perez Escriva P, Letellier E, Mosig AS, Wilmes P
An Organ-on-Chip platform for simulating drug metabolism along the Gut-Liver axis.
Adv Health Mater. 2024 Aug; 13(20): e2303943. doi: 10.1002/adhm.202303943

Kaden T, Alonso-Roman R, Akbarimoghaddam P, Mosig AS, Graf K, Raasch M, Hoffmann B, Figge MT, Hube B, Gresnigt MS
Modelling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathologenicity.
Biomaterials. 2024 Jun; 307:122525. doi: 10.1016/j.biomaterials.2024.122525

Franzka P, Mittag S, Chakraborty A, Huber O, Hübner CA
Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity.
Front Mol Neurosci. 2024 Jun 24;17:1375297. doi: 10.3389/fnmol,2024.1375297

Felipe Fumero E, Walter C, Frenz JM, Seifert F, Alla V, Hennig T, Angenendt L, Hartmann W, Wolf S, Serve H, Oellerich T, Lenz G, Müller-Tidow C, Schliemann C, Huber O, Dugas M, Mann M, Jayavelu AK, Mikesch JH, Arteaga MF
Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia.
Blood. 2024 May 30;143(22):2284-2299. doi: 10.1182/blood.2023021640

Koceva H, Amiratashani M, Rennert K, Mosig AS
Immunocompetent Alveolus-on-Chip Model for Studying Alveolar Mucosal Immune Responses.
J Vis Exp. 2024 May 31;(207), e66602. doi: 10.3791/66602

Feile A, Wegner VD, Raasch M, Mosig AS
Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses.
J Vis Exp. 2024 May 24;(207), e66603. doi: 10.3791/66603

Ehle C, Iyer-Bierhoff A, Wu Y, Xing S, Kiehntopf M, Mosig AS, Godmann M, Heinzel T
Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response.
Commun Biol. 2024 May 16;7(1):589. doi: 10.1038/s42003-024-06288-1

Kowalczuk K, Dasgupta A, Páez Larios F, Ulrich HF, Wegner V, Brendel JC, Eggeling C, Mosig AS, Schacher FH
Self-Degrading Multifunctional PEG-Based Hydrogels-Tailormade Substrates for Cell Culture.
Macromol Biosci. 2024 May;24(5):e2300383. doi: 10.1002/mabi.202300383

Kowalczuk K, Wegner VD, Mosig AS, Schacher FH
Tailoring the Degradation Time of Polycationic PEG-Based Hydrogels toward Dynamic Cell Culture Matrices.
ACS Appl Bio Mater. 2024 Apr 15;7(4):2402-2412. doi: 10.1021/acsabm.4c00057

Alonso-Roman R, Mosig AS, Figge MT, Papenfort K, Eggeling C, Schacher FH, Hube B, Gresnigt MS
Organ-on-chip models for infectious disease research.
Nat Microbiol. 2024 Apr;9(4):891-904. doi: 10.1038/s41564-024-01645-6

Ma Y, Nenkov M, Berndt A, Abubrig M, Schmidt M, Sandhaus T, Huber O, Clement J, Lang SM, Chen Y, Gaßler N
The diagnostic value of ACSL1, ACSL4 and ACSL5 and the clinical application of ACSL inhibitor in non-small cell lung cancer.
Cancers (2024) Mar 16;16(6), 1170: doi: 10.3390/cancers16061170

Roth A, Tannert A, Ziller N, Eiserloh S, Göhrig B, Guliev RR, Gonzalez Vazquez MJ, Naumann M, Mosig AS, Stengel S, Heutelbeck ARR, Neugebauer U
Quantification of polystyrene uptake by different cell lines using fluorescence microscopy and label-free visualization of intracellular polystyrene particles by raman microspectroscopic imaging.
Cells. 2024, Mar 5;13(5):454. doi: 10.3390/cells13050454

Kowalczuk K, Mons PJ, Ulrich HF, Wegner VD, Brendel JC, Mosig AS, Schacher FH
Asymmetric block extension of star-shaped [PEG-SH]4 - toward poly(dehydroalanine)-functionalized PEG hydrogels for catch and release of charged guest molecules.
Macromol Biosci. (2024) Feb 24(2):e2300230. doi: 10.1002/mabi.202300230

Nistor M, Schmidt M, Klingner C, Klingner C, Matziolis G, Shayganfar S, Schiffner R
Effect of low-frequency renal nerve stimulation on renal glucose release during normoglycemia and a hypoglycemic clamp in pigs.
J Mol Sci. (2024) Feb 7;25(4):2041.doi: 10.3390/ijms25042041

Mohamed SMA, Schofield P, McCalmont H, Moles E, Friedrich KH, Kavallaris M, Christ D, Bayat N, Lock RB
An antibody fragment-decorated liposomal conjugate targets Philadelphia-like acute lymphoblastic leukemia.
Int J Biol Macromol. (2024) Jan; 254(PT 1):127596. doi:10.1016/j.ijbiomac.2023.127596

Fahrner R, Gröger M, Settmacher U, Mosig AS
Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model.
BMC Res Notes. (2023) Oct 21; 16(1):285. doi:10.1186/s13104-023-06575-w

Kaden T, Graf K, Rennert K, Li R, Mosig AS, Raasch M
Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. 
Sci Rep. (2023) Aug 16;13(1): 13338. doi:10.1038/s41598-023-40004-z

Nistor M, Schmidt M, Klingner C, Klingner C, Schwab M, Bischoff SJ, Matziolis G, Rodriguez-Gonzales GL, Schiffner R
Renal Glucose Release after Unilateral Renal Denervation during a Hypoglycemic Clamp in Pigs with an Altered Hypothalamic Pituitary Adrenal Axis after Late-Gestational Dexamethasone injection.
Int J Mol Sci. (2023) Aug 13;24 (16): 12738.doi: 10.3390/ijms241612738

Ney LM, Wipplinger M, Grossmann M, Engert N, Wegner VD, Mosig SD
Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections.
Open Biol. (2023) Mar; 13(3), 230014. doi: 10.1098/rsob. 230014

Kaiser A, Eiselt G, Bechler J, Huber O, Schmidt M
WNT3a Signaling inhibits aromatase expression in breast adipose fibroblasts-A possible mechanism supporting the loss of estgrogen responsiveness of triple-negative breast cancers.
Int J Mol Sci. (2023) Feb28;24(5):4654.doi:10.3390/ijms24054654

Zhang D, Tang W, Niu H, Tse W, Ruan HB, Dolznig H, Knösel T, Friedrich KH, Themanns M, Wang J, Song M, Denson L, Kenner L, Moriggl R, Zheng Y, Han X
Monogenic deficiency in murine intestinal CdC42 leads to mucosal inflammation that induces crypt dysplasia. 
Genes Dis. (2023) Jan 2;11 (1): 413-429. doi:10.1016/j.gendis.2022.11.024. eCollection 2024 Jan

Mittag S, Wetzel F, Müller SY, Huber O
The Rosetta Stone hypothesis-based interaction of the tumor suppressor proteins Nit1 and Fhit. 
Cells. (2023) 12(3), 353; https://doi.org/10.3390/cells12030353

Klaus FL, Kirsch C, Müller JP, Huber O, Reiche J
PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6. 
Ann NY Acad Sci (2022) Sep;1515 (1): 196-207. doi:10.11111/nyas.14842.

Cano-Cortina M, Alarcon L, Miranda J, Huber O, Gonzales-Mariscal L
Polyubiquitination and SUMOylation sites regulate the stability of ZO-2-protein and the sealing of tight junctions. 
Cells. (2022) Oct 19;11(20):3296. doi: 10.3390/cells11203296.PMID: 36291162

Ma Y, Marinkova R, Nenkov M, Jin L, Huber O, Sonnemann J, Peca N, Gaßler N, Chen Y
Tumor-intrinsic PD-L1 exerts an oncogenic function through the activation of the Wnt/β-Catenin pathway in human non-small cell lung cancer. 
Int.J.Mol.Sci. (2022) Sep 20;23(19):11031. doi: 10.3390/ijms231911031.PMID:36232331

Siwczak F, Cseresnyes Z, Hassan MIA, Aina KO, Carlstedt S, Sigmund A, Gröger M, Surewaard BGJ, Werz O, Figge MT, Tuchscherr L, Loffler B, Mosig AS
Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model. 
Biomaterials. (2022) Jun 16;287:121632. doi: 10.1016/j.biomaterials.2022.121632.PMID: 35728409

Ehsani M, Bartsch S, Rasa SMM, Dittmann J, Pungsrinont T, Neubert L, Huettner SS, Kotolloshi R, Schindler K, Ahmad A,   Mosig AS, Adam L, Ori A, Neri F, Berndt A, Grimm MO, Baniahmad A.
The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2. 
Oncogene. (2022) Jun;41(23):3263-3277. doi: 10.1038/s41388-022-02333-7. Epub 2022 May 5.PMID: 35513564

Takahashi S, Fukuhara D, Kimura T, Fukutomi T, Tanaka E, Mikami N, Hada I, Takematsu H, Nishibori Y, Akimoto Y, Kiyonari H, Abe T, Huber O, Yan K.
USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage. 
Biochem Biophys Res Commun. (2022) Jul 23;614:198-206. doi: 10.1016/j.bbrc.2022.05.043. Epub 2022 May 14.

Shroff T, Aina K, Maass C, Cipriano M, Lambrecht J, Tacke F, Mosig A, Loskill P
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics. 
Open Biol. (2022) Mar;12(3):210333. doi:10.1098/rsob.210333.Epub 2022 Mar2

Knauthe A, Mittag S, Bloch L, Albring KF, Schmidt M, Werz O, Huber O
Hyperforin and myrtucommulone derivatives act as natural modulators of Wnt/β-Catenin signaling in HCT116 colon cancer cells. 
Int J Mol Sci. (2022) Mar 10;23(6):2984. doi:10.3390/ijms23062984

Hoang TNM, Cseresnyés Z, Hartung S, Blickensdorf M, Saffer C, Rennert K, Mosig AS, von Lilienfeld-Toal M, Figge MT
Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection. 
Biomaterials. (2022) Apr;283:121420. doi: 10.1016/j.biomaterials.2022.121420. Epub 2022 Feb 24.PMID: 35245733

Marković I, Wolfrum T, Wohlmann A, Gautam K, Friedrich K.
Functional characterisation of two receptor interaction determinants in human thymic stromal lymphopoietin. 
Biol Chem. 2021 Oct 26;403(2):243-249. doi: 10.1515/hsz-2021-0293. Print 2022 Jan 27.PMID: 34699696

Last A, Maurer M, Mosig AS, Gresnigt MS, Hube B
In vitro models to study fungal-host interactions. 
FEMS Microbiol Rev (2021) 1-22, 45(5) fuab005. doi:10.1093/femsre/fuab005.

Siwczak F, Loffet E, Kaminska M, Koceva H, Mahe MM, Mosig AS
Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction.
Front.Immunol (2021) 12:798552. doi:10.3389/fimmun.2021.798552.

Mohamed SMA, Wohlmann A, Schofield P, Sia KCS, McCalmont H, Savvides SN, Verstraete K, Kavallaris M,Christ D, Friedrich KH, Bayat N, Lock RB
A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia. 
Int J Biol Macromol (2021) 190:214-223. doi:10.1016/j.ijbiomac.2021.08.194.

Tremante E, Sibilio L, Centola F, Knutti N, Holzapfel G, Manni I, Allegretti M, Lombardi P, Salvo G, Ceccetelli L, Friedrich KH, Bertram J, Giacomini P
TOOLBOX: Strep-Tagged nano-assemblies of antibody-drug-conjugates (ADC) for modular and conditional cancer drugging. 
Oncol Rep (2021) 45(5):77. doi:10.3892/or.2021.8028.

Neukirch K, Alsabil K, Dinh C, Bilancia R, Raasch M, Ville A, Cerqua I, Viault G, Bréard D, Pace S, Temml V, Brunner E, Jordan P, Marques M, Loeser K, Gollowitzer A, Permann S, Gerstmeier J, Lorkowski S, Stuppner H, Garscha U, Rodrigues T, Bernardes G, Schuster D, Seraphin D, Richomme P, Rossi A, Mosig AS, Roviezzo F, Werz O, Helesbeux JJ, Koeberle A
Exploration of long-chain vitamin E metabolites for the discovery of a highly potent, orally effective and metabolically stable 5-LOX inhibitor that limits inflammation. 
J Med Chem(2021) 64(15):11496-11526. doi:10.1021/acs.jmedchem.1c00806.

Lucchetti M, Kaminska M, Oluwasegun AK, Mosig AS, Wilmes P
Emulating the gut-liver axis: Dissecting the microbiome´s effect on drug metabolism using multiorgan-on-chip models. 
Curr Opin Endocr Metab Res. (2021) Jun 18;94-101. doi:10.1016/j.coemr.2021.03.003.

Franzka P, Henze H, Jung MJ, Schüler SC, Mittag S, Biskup K, Liebmann L, Kentache T, Morales J, Martinez B, Katona I, Herrmann T, Huebner AK, Hennings JC, Groth S, Gresing L, Horstkorte R, Marquardt T, Weis J, Kaether C, Mutchinick OM, Ori A, Huber O, Blanchard V, von Maltzahn J, Hübner CA
GMPPA defects cause a neuromuscular disorder with a-dystroglycan hyperglycosylation. 
J Clin Invest. (2021) May 3;131(9):e139076. doi:10.1172/JCI139076.

Monti G, Kjolby M, Jensen AMG, Allen M, Reiche J, Møller PL, Comaposada-Baró R, Zolkowski BE, Vieira C, Jørgensen MM, Holm IE, Valdmanis PN, Weller N, Vægter CB, Lincoln SJ, Nykjær A, Ertekin-Taner N, Young JE, Nyegaard M, Andersen OM
Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer´s disease. 
Acta Neuropathol Commun. (2021) Mar 16;9(1):43. doi:10.1186/s40478-021-01140-7.

Deinhardt-Emmer S, Böttcher S, Häring C, Giebeler L, Henke A, Zell R, Jungwirth J, Jordan PM, Werz O, Hornung F, Brandt C, Marquet M, Mosig AS, Pletz MW, Schacke M, Rödel J, Heller R, Nietzsche S, Löffler B, Ehrhardt C
SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction. 
J Virol. (2021) Feb 26;95(10):e00110-21. doi:10.1128/JVI.00110-21.

Heinze K, Hölzer M, Ungelenk M, Gerth M, Thomale J, Heller R, Morden CR, McManus KJ, Mosig AS, Dürst M, Runnebaum IB, Häfner N
RUNX3 transcript variants have distinct roles in ovarian carcinoma and differently influence platinum sensitivity and angiogenesis. 
Cancers (Basel) (2021) Jan 26;13(3):476. doi:10.3390/cancers13030476. PMID:33530588.

Reiche J, Huber O
Post-translational modifications of tight junction transmembrane proteins and their direct effect on barrier function. 
Biochim Biophys Acta Biomembr. (2020) Sep 1;1862(9):183330. doi:10.1016/j.bbamem.2020.183330.

Kaiser A, Schmidt M, Huber O, Frietsch JJ, Scholl S, Heidel FH, Hochhaus A, Müller JP, Ernst T
SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders. 
Leukemia. (2020) Aug 34(8): 2206-2216. doi:10.1038/s41375-020-0803-3. Epub 2020 Mar 25

Yanakieva D, Elter A, Bratsch J, Friedrich K, Becker S, Kolmar H
FACS-based functional protein screening via microfluidic co-encapsulation of yeast secretor and mammalian reporter cells. 
Sci Rep. (2020) Jun 23; 10(1):10182. doi:10.1038/s41598-020-66927-5.

Schicke E, Cseresnyés Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S, Siwczak F, Schmidtke M, Glück B, Koch M, Schacke M, Heller R, Mosig AS, Figge MT, Ehrhardt C, Löffler B, Deinhardt-Emmer S
Staphylococcus aureus lung infection results in down-regulation of surfactant Protein-A mainly caused by pro-inflammatory macrophages. 
Microorganisms. (2020) Apr 16;8(4). pii:E577.doi:10.3390/microorganisms8040577

Spengler K, Kryeziu N, Große S, Mosig AS, Heller R
VEGF triggers transient induction of autophagy in endothelial cells via AMPKα1. 
Cells. (2020) Mar 11;9(3). pii:E687.doi:10.3390/cells9030687

Schubert M, Becher S, Wallert M, Maeß MB, Abhari M, Rennert K, Mosig AS, Große S, Heller R, Grün M, Lorkowski S
The Peroxisome Proliferator-Activated Receptor (PPAR)-γ antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) triggers Perilipin 2 expression via PPARδ and induces lipogenesis and triglyceride accumulation in human THP-1 macrophages. 
Mol Pharmacol. (2020) Mar;97(3):212-225. doi:10.1124/mol.119.117887

Schiffner R, Bischoff SJ, Lehmann T, Irintchev A, Nistor M, Lemke C, Schmidt M
Altered cerebral blood flow and potential neuroprotective effect of human Relaxin-2 (Serelaxin) during hypoxia or severe hypovolemia in a sheep model. 
Int J Mol Sci. (2020) Feb 27;21(5). pii: E1632. doi:10.3390/ijms21051632

Kaiser A, Krüger T, Eiselt G, Bechler J, Kniemeyer O, Huber O, Schmidt M
Identification of PARP-1, Histone H1 and SIRT-1 as new regulators of breast cancer-related Aromatase promoter I.3/II. 
Cells. (2020) Feb 12;9(2). pii:E427.doi:10.3390/cells9020427

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS
A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. 
Biomaterials. (2019) Nov;220:119396.doi:10.1016/j.biomaterials.2019.119396. Epub 2019 Aug 2

Ye Z, Mittag S, Schmidt M, Simm A, Horstkorte R, Huber O
Wnt glycation inhibits canonical signaling. 
Cells. (2019) Oct 25;8(11). pii: E1320. doi:10.3390/cells8111320

Janke S, Mittag S, Reiche J, Huber O
Apoptotic Fragmentation of Tricellulin. 
Int J Mol Sci. (2019) Oct 1;20(19). pii:E4882. doi:10.3390/ijms20194882

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Gröger M, Mosig AS, Gresnigt MS, Hube B
Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. 
Dis Model Mech. (2019) Sep 12;12(9). pii: dmm039719. doi:10.1242/dmm.039719

Richter JF, Hildner M, Schmauder R, Turner JR, Schumann M, Reiche J
Occludin knockdown is not sufficient to induce transepithelial macromolecule passage. 
Tissue Barriers. (2019) 7(2):1612661. doi:10.1080/21688370.2019.1608759. Epub 2019 Jun 4

Raasch M, Fritsche E, Kurtz A, Bauer M, Mosig AS
Microphysiological systems meet hiPSC technology - New tools for desease modeling of liver infections in basic research and drug development. 
Adv Drug Deliv Rev. (2019) Feb 1;140:51-67. doi:10.1016/j.addr.2018.06.008 Epub 2018 Jun 15

Khemiri M, Doghri R, Mrad K, Friedrich K, Oueslati R
Mucin-1 expression and localization in epithelial  cells shows characteristic and distinct patterns in inflammatory bowel diseases and colorectal cancer. 
Int J Clin Exp Pathol. (2019) May 1;12(5). 1731-1737 eCollection 2019

Raasch M,Fritsche E, Kurtz A, Bauer M, Mosig AS
Microphysiological systems meet hiPSC technology - New tools for desease modeling of liver infections in basic research and drug development. 
Adv Drug Deliv Rev. (2019) Feb 1;140:51-67. doi:10.1016/j.addr.2018.06.008 Epub 2018 Jun 15

Knutti N, Huber O, Friedrich K 
CD147 (EMMPRIN) controls malignant properties of breast cancer cells by interdependent signaling of Wnt and JAK/STAT pathways. 
Mol Cell Biochem. (2019) Jan;451(1-2):197-209.doi:10.1007/s11010-018-3406-9. Epub 2018 Jul 18

Markovic I, Barthel T, Schirmer M, Gonzalez Delgado A, Wilhelm S, Krause S, Friedrich K, Wohlmann A 
A versatile platform for activity determination of cytokines and growth factors based on the human TSLP (thymic stromal lymphopoietin) receptor. 
Cytokine. (2019) Jan; 113:228-237. doi: 10.1016/j.cyto.2018.07.010. Epub 2018 Jul 19

Nistor M, Schmidt M, Graul I, Rakers F, Schiffner R
A systematic review of neuroprotective strategies in the management of hypoglycemia.
Int J Mol Sci. (2019) 20, 550; doi: 10.3390/ijms20030550

Leonhardt J, Große S, Marx C, Siwczak F, Stengel S, Bruns T, Bauer R, Kiehntopf M, Williams DL, Wang ZQ, Mosig AS, Weis S, Bauer M, Heller R 
Candida albicans β-glucan differentiates human monocytes into a specific subset of macrophages. 
Front Immunol. (2018) Nov 30;9:2818. doi: 10.3389/fimmu.2018.02818. eCollection 2018

Reiche J, Schumann M, Richter JF 
The sandwich assay: A method for subcellular visualization of paracellular macromolecule passage in epithelial sheets. 
Curr Protoc Cell Biol. (2018) Mar;78(1)20.10.1-20.10.13. doi: 10.1002/cpcb.42

Heinze K, Kritsch D, Mosig AS, Dürst M, Häfner N, Runnebaum IB
Functional analysis of RUNX3 and CaMKIINα in ovarian cancer cell lines reveal tumor-suppressive functions for CaMKIINα and Dichotomous roles for RUNX3 transcript variants.
Int J Mol Sci. (2018) Jan 15;19(1). pii:E253. doi: 10.3390/ijms19010253

Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Seraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
Nat Commun.  (2018) Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5

Crncec I, Modak M, Gordziel C, Svinka J, Scharf I, Moritsch S, Pathria P, Schlederer M, Kenner L, Timelthaler G, Müller M, Strobl B, Casanova E, Beyer E, Mohr T, Stöckl J, Friedrich K, Eferl R
STAT1 is a sex-specific tumor supressor in colitis-associated colorectal cancer.
Mol Oncol. (2018) Apr;12(4):514-528 doi. 10.1002/1878-0261.12178.Epub 2018 Feb 20

Schiffner R, Bischoff SJ, Lehmann T, Rakers F, Rupprecht S, Matziolis G, Schubert H, Schwab M, Huber O, Lemke C, Schmidt M
Underlying mechanism of subcortical brain protection during hypoxia and reoxygenation in a sheep model - Influence of ?1-adrenergic signalling.
PLoS ONE 13 (2018) e0196363. https://doi. org/10.1371/journal.pone.0196363

Schiffner R, Nistor M, Bischoff SJ, Matziolis G, Schmidt M, Lehmann T 
Effects of human relaxin-2 (serelaxin) on hypoxic pilmonary vascoconstriction during acute hypoxia in a sheep model.
Hypoxia 6 (2018) 11-22. doi:10.2147/HP.S165092

Schiffner R, Lehmann T,Bischoff SJ, Zippelius T, Nistor M, Schmidt M
Pulmonary hemodynamic effects and pulmonary arterial compliance during hypovolemic shock and reinfusion with human relaxin-2 (serelaxin) treatment in a sheep model.
Clin Hemorheol Microcirc. (2018) April 14 doi:10.3233/CH-180382. [Epub ahead of prin]

Nistor M, Schmidt M, Schiffner R 
The relaxin peptide family - potential future hope for neuroprotective therapy? A short review.
Neural Regen Res. (2018) Mar;13(3):402-405. doi:10.4103/1673-5374.228713 

Nistor M, Behringer W, Schmidt M, Schiffner R
A systematic review of neuroprotective stratagies during hypovolemia and hemorrhagic shock.
Int J Mol Sci. (2017) Oct 26;18(11). pii: E2247. doi: 10.3390/ijms 18112247

Schiffner R, Rodriguez-Gonzales GL, Rakers F, Nistor M, Nathanielsz PW, Daneva T, Schwab M, Lehmann T, Schmidt M
Effects of late gestational fetal exposure to dexamethasone administration on the postnatal hypothalamus-pituitary-adrenal acis response to hypoglycemia in pigs.
Int J Mol Sci. (2017) Oct 27;18(11). pii: E2241. doi: 10.3390/ijms 18112241

Rennert K, Nitschke M, Wallert M, Keune N, Raasch M, Lorkowski S, Mosig AS
Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency.
J Tissue Eng. (2017) Aug 25;:2041731417726428. doi: 10.1177/2041731417726428. eCollection 2017 Jan-Dec

Schiffner R, Reiche J, Brodt S, Brinkmann O, Bungartz M, Matziolis G, Schmidt M
A simple procedure for the evaluation of bone vitality by staining with a Tetrazolium salt.
Int J Mol Sci. (2017) Jul 28;18(8). pii: E1646. doi: 10.3390/ijms 18081646

Mosig AS
Organ-on-chip models: new opportunities for biomedical research.
Future Sci OA. (2016) Jul 6;3(2):FSO130. doi:10.4155/fsoa-2016-0038. eCollection 2017 Jun

Jennek S, Mittag S, Reiche J, Westphal JK, Seelk S, Dörfel MJ, Pfirrmann T, Friedrich K, Schütz A, Heinemann U, Huber O 
Tricellulin is a target of the ubiquitin ligase Itch.
Ann N Y Acad Sci. (2017) Juni; 1397 (1):157-168. doi:10.1111/nyas.13349

Schiffner R, Reiche J, Schmidt M, Jung C, Walther S, Irintchev A,  Bischoff SJ 
Pulmonary arterial compliance and pulmonary hemodynamic effects of Serelaxin in a sheep model.
Clin Hemorheol Microcirc. (2017) 66, 219-229. doi:10.3233/CH-170269

Schiffner R, Bischoff SJ, Lehmann T, Rakers F, Rupprecht S, Reiche J, Matziolis G, Schubert H, Schwab M, Huber O, Schmidt M
Redistribution of Cerebral Blood Flow during Severe Hypovolemia and Reperfusion in a Sheep Model: Critical Role of α1-Adrenergic Signaling.
Int J Mol Sci. (2017) May 11;18(5). pii: E1031. doi:10.3390/ijms18051031

Schiffner R, Bischoff SJ, Matziolis G, Schmidt M
Evaluation of a vital staining protocol with 2,3,5-triphenyltetrazolium chloride for cancellous bone in a sheep model.
Res Vet Sci. (2017) Mar 27;114:131-135. doi: 10.1016/j.rvsc.2017.03.013

Bork K, Weidemann W, Berneck B, Kuchta M, Bennmann D, Thate A, Huber O, Gnanapragassam VS, Horstkorte R
The expression of sialyltransferase is regulated by the bioavailability and biosynthesis of sialic acids.
Gene Expr Patterns. (2017) Mar 27;23-24:52-58. doi: 10.1016/j.gep.2017.03.003

Hanisch C, Sharbati J, Kutz-Lohroff B, Huber O, Einspanier R, Sharbati S
Trefoil factor 3 mediates resistance to apoptosis in colon carcinoma cells by a regulatory RNA axis.
Cell Death Dis. (2017) Mar 9;8(3):e2660. doi: 10.1038/cddis.2017.84

Friedrich K, Dolznig H, Han X, Moriggl R
Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3.
Biosci Trends. (2017) Mar 22;11(1):1-8. doi: 10.5582/bst.2016.01250

Thomas L, Rao Z, Gerstmeier J, Raasch M, Weinigel C, Rummler S, Menche D, Müller R, Pergola C, Mosig A, Werz O
Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase.
Biochem Pharmacol. (2017) Apr 15;130:71-82. doi: 10.1016/j.bcp.2017.02.004

Hass R, Jennek S, Yang Y, Friedrich K
c-Met expression and activity in urogenital cancers - novel aspects of signal transduction and medical implications.
Cell Commun Signal. (2017) Feb 17;15(1):10. doi: 10.1186/s12964-017-0165-2

Hanisch C, Sharbati J, Kutz-Lohroff B, Huber O, Einspanier R, Sharbati S
TFF3-dependent resistance of human colorectal adenocarcinoma cells HT-29/B6 to apoptosis is mediated by miR-491-5p regulation of IncRNA PRINS.
Cell Death Discov. (2017) Jan 30;3:16106. doi: 10.1038/cddiscovery.2016.106

Schüler R, Osterhoff MA, Frahnow T, Seltmann AC, Busjahn A, Kabisch S, Xu L, Mosig AS, Spranger J, Möhlig M, Hornemann S, Kruse M, Pfeiffer AF
High-saturated-fat diet increases circulating angiotensin-converting enzyme, which is enhanced by the rs4343 polymorphism defining persons at risk of nutrient-dependent increases of blood pressure.
J Am Heart Assoc. (2017) Jan 17;6(1). pii:e004465. doi 10.1161/JAHA.116.004465

Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, Hüttel S, Zahler S, Vollmar AM, Weinigel C, Rummler S, Müller R, Raasch M, Mosig A, Koeberle A, Werz O
Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy.
Sci Rep. (2017) Jan 30;7:41434. doi: 10.1038/srep41434

Wetzel F, Mittag S, Cano-Cortina M, Wagner T, Krämer OH, Niedenthal R, Gonzalez-Mariscal L, Huber O
SUMOylation regulates the intracellular fate of ZO-2.
Cell Mol Life Sci. (2017) Jan; 74(2):373-392. (DOI:10.1007/s00018-016-2352-5)

Nivarthi H, Gordziel C, Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S, Friedrich K, Moriggl R
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Oncotarget. (2016) 7 (32), 51096-51106, DOI: 10.18632/oncotarget.9315

Nivarthi H, Gordziel C, Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S, Friedrich K, Moriggl R
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Oncotarget. (2016) 7 (32), 51096-51106, DOI: 10.18632/oncotarget.9315

Cindric Vranesic A, Reiche J, Hoischen C, Wohlmann A, Bratsch J, Friedrich K, Günes B, Capppallo-Obermann H, Kirchhoff C, Diekmann S, Günes C, Huber O
Characterization of SKAP/kinastrin isoforms: the N-terminus defines tissue specificity and Pontin binding.
Hum Mol Genet. (2016) 25, 2838-2852

Englert C, Trützschler AK, Raasch M, Bus T, Borchers P, Mosig AS, Traeger A, Schubert US
Crossing the blood-brain barrier: Glutathione-conjugated poly/ethylene imine) for gene delivery.
J Control Release (2016) Nov 10;241:1-14. (DOI:1016/j.jconrel.2016.08.039)

Mittag S, Valenta T, Weiske J, Bloch L, Klingel S, Gradl D, Wetzel F, Chen Y, Petersen I, Basler K, Huber O 
A novel role for the tumor suppressor Nitrilase 1 modulating the Wnt/β-catenin signaling pathway. 
Cell Discovery (2016) 2: 15039 (DOI: 10.1038/celldisc.2015.39)

Bloch L, Ndongson-Dongmo B, Kusch A, Dragun D, Heller R, Huber O
Real-time monitoring of hypertrophy in HL-1 cardiomyocytes by impedance measurements reveals different modes of growth.
Cytotechnology (2016) Oct; 68(5):1897-907. DOI:10.1007/s10616-016-0001-3. Epub 2016 Jul 5

Press AT, Ungelenk L, Rinkenauer AC, Gröger M, Lehmann F, Mosig A, Schubert US, Clemens MG, Bauer M
A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo.
J Biophotonics (2016) Sep;9(9):888-900.doi: 10.1002/jbio.201500190. Epub 2015 Nov 13

Bischoff SJ, Schmidt M, Lehmann T, Irintchev A, Schubert H, Jung C, Schwab M, Huber O, Matziolis G, Schiffner R
Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model.
Am J Physiol Heart Circ Physiol (2016) Sep 5;311(3):H613-20. doi: 10.1152/ajpheart. 00118.2016. Epub 2016 Jul 8

Raasch M, Rennert K, Jahn T, Gärtner C, Schönfelder G, Huber O, Seiler AE, Mosig AS
An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development.
Biomicrofluidics (2016) Jul 5;10(4):044102. DOI:10.1063/1.4955184. eCollection 2016 Jul.

Rennert K, Heisig K, Gröger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig AS
Recruitment of CD16+ monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine.
Cytokine. (2016) Mar 28;83:41-52 (DOI: 10.16/j.cyto2016.03.017)

Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, Claus RA, Huber O, Mosig AS
Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model.
Sci Rep. (2016) Feb 23;6:21868 (DOI: 10.1038/srep21868)

Rennert K, Otto P, Funke H, Huber O, Tomaso H, Mosig AS
A human macrophage - hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica.
BMC Microbiol. (2016) Jan 6;16(1):2 (DOI: 10.1186/s12866-015-0621-3)

Vetter T, Borowski A, Wohlmann A, Ranjan N, Juepper M, Badura S, Ottmann OG, Friedrich K
Blockade of thymic stromal lymphopoietin (TSLP) receptor inhibits TSLP-driven prolifertion and signalling in lymphoblasts from a subset of B-precursor ALL patients.
Leuk Res. (2016) Jan;40:38-43 (DOI: 10.1016/j.leukres.2015.10.003.) Epub 2015 Oct 22

Bischoff SJ, Schmidt M, Lehmann T, Schwab M, Matziolis G, Saemann A, Schiffner R
Renal glucose release during hypoglycemia is partly controlled by sympathetic nerves - a study in pigs with unilateral surgically denervated kidneys.
Physiol Rep (2015) 3: e12603 (DOI: 10.14814/phy2.12603)

Rennert K, Steinborn S, Gröger M, Ungerböck B, Jank AM, Ehgartner J. Nietzsche S, Dinger J, Kiehntopf M, Funke H, Peters FT, Lupp A, Gärtner C, Mayr T, Bauer M, Huber O, Mosig AS
A microfluidically perfused three dimensional human liver model.
Biomaterials (2015) 71: 119-131

Knutti N, Kuepper M, Friedrich K
Soluble extracellular matrix metalloproteinase inducer (EMMPRIN, EMN) regulates cancer-related cellular functions by homotypic interactions with surface CD147.
FEBS J (2015) 282: 4187-4200

Huber O, Petersen I
Desmosomes and the hallmarks of cancer.
Cell Commun Adh (2015) 22: 15-28

Sellmann C, Priebs J, Landmann M, Degen C, Engstler AJ, Jin CJ, Gärttner S, Spruss A, Huber O, Bergheim I
Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of non-alcoholic fatty liver diseases over time.
J Nutr Biochem (2015) 26: 1183-1192

Multhaup G, Huber O, Buée L, Galas MC
APP metabolites AICD, Abeta42 and Tau in nuclear roles.
J Biol Chem (2015) 290: 23515-23522

Schmidt M, Straub RH                                                                                                  RH11β-hydroxysteroid dehydrogenase enzymes modulate effects of glucocorticoids in rheumatoid arthritis synovial cells. 
Neuroimmunomodulation (2015) 22:40-45 (DOI: 10.1159/000362725)

Stark K, Straub RH, Rovensky J, Blažičková S, Eiselt G, Schmidt M
CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women.
Arthritis Res Ther (2015) 17, 56 (DOI: 10.1186/s13075-015-0574-9)

Maeß MB, Keller AA, Rennert K, Mosig A, Lorkowski S.
Optimization of the transfection of human THP-1 macrophages by application of Nunc UpCell technology.
Anal Biochem. 2015 Feb 4;479:40-42

Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, Becker H, Lorkowski S, Funke H, Mosig A.
Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions.
Biofabrication. 2015 Mar 2;7(1):015013

Schütz A, Röser K, Klitzsch J, Lieder F, Aberger F, Gruber W, Mueller KM, Pupyshev A, Moriggl R, Friedrich K.
Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation.
Transl Oncol. 2015 Apr;8(2):97-105

Grimm S, Jennek S, Singh R, Enkelmann A, Junker K, Rippaus N, Berndt A, Friedrich K.
Malignancy of bladder cancer cells is enhanced by tumor-associated fibroblasts through a multifaceted cytokine-chemokine loop.
Exp Cell Res. 2015 Apr 22. pii: S0014-4827(15)00122-6

Hatina J, Kripnerová M, Tuková J, Šrámek J, Dvořák P, Pešta M, Dobrá J, Babuška V, Racek J, Sobol M, Philimonenko A, Hozák P, Czuba Z, Schulz WA, Strell C, Grimm S, Jennek S, Friedrich KH.
Tumour-stroma interactions in urothelial cancer.
Urologe A. 2015 Apr;54(4):516-25

Fuller SJ, McMillan DG, Renz MB, Schmidt M, Burke IT, Stewart DI
Extracellular electron transport mediated Fe(III) reduction by a community of alkaliphilic bacteria that use flavins as electron shuttles.
Appl. Environ. Microbiol. (2014) 80:128-37

Augsten M, Böttcher A, Spanbroek R, Rubio I, Friedrich K
Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains.
Cell Commun Signal (2014) 12:1

Pergola C, Gaboriaud-Kolar N, Jestädt N, König S, Schaible AM, Li H, Garscha U, Weinigel C, Barz D, Albring KF, Huber O, Skaltsounis AL, Werz O
The indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.
J Med Chem (2014) 57:3715-3723

Müller S, Chen Y, Ginter T, Schäfer C, Buchwald M, Schmitz ML, Klitzsch J, Schütz A, Haitel A, Schmidt K, Moriggl R, Kenner L, Friedrich K, Haan C, Petersen I, Heinzel T, Krämer OH
SIAH2 antagonizes TYK-STAT3 signaling in lung carcinoma cells.
Oncotarget (2014) 5:3184-3196

Böhmer FD, Friedrich K
Protein tyrosine phosphatases as wardens of STAT signaling.
JAKSTAT (2014)3(1):e28087

Albring KF, Weidemüller J, Mittag S, Weiske J, Friedrich K, Geroni MC, Lombardi P, Huber O
Berberine acts as a natural inhibitor of Wnt/β-catenin signalling - identification of more active 13-arylalkyl derivatives.
Biofactors (2013) 39(6):652-62

Wilde J, Erdmann M, Mertens M, Eiselt G, Schmidt M
Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor α.
Journal of Molecular Endocrinology (2013) 51, 247-260

Gordziel C, Bratsch J, Moriggl R, Knösel T, Friedrich K
Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma.
Brit J Cancer (2013) 109, 138-46

Dörfel MJ, Westphal JK, Bellmann C, Krug SM, Cording J, Mittag S, Tauber R  Fromm M, Blasig IE, Huber O
CK2-dependent phosphorylation of occludin regulates its interaction with ZO-proteins and tight junction integrity.
Cell Commun Signal (2013) 11:40

Rosenbaum J, Baek SH, Dutta A, Houry WA, Huber O, Hupp TR, Matias PM
The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape.
Sci Signal (2013) 6, mr1

Bautista-Garcia P, Reyes JL, Martin D, Namorado MC, Chavez-Munguía B, Soria-Castro E, Huber O, González-Mariscal
Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice.
Am J Physiol - Renal Physiol (2013) 304, F77-F87

Cording J, Berg J, Käding N, Bellmann C, Tscheik C, Westphal JK, Milatz S, Günzel D, Wolburg H, Piontek J, Huber O, Blasig I
In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvel D3, which, inversely, modulate the claudin oligomerization.
J Cell Sci (2013) 126, 554-564

Borowski A, Vetter T, Kuepper M, Wohlmann A, Krause S, Lorenzen T, Virchow JC, Luttmann W, Friedrich K
Expression analysis and specific blockade of the receptor for human thymic stromal lymphopoietin (TLSP) by novel antibodies to the human TSLPRa receptor chain.
Cytokine (2013) 61, 546-555

Briest F, Berndt A, Clement J, Junker K, Eggeling F, Grimm S, Friedrich K
Tumor-stroma interactions in tumorigenesis: lessions from stem cell biology.
Front Biosci (2012) 4, 1871-1887

Dörfel MJ, Huber O
Modulation of tight junction structure and function by kinases and phosphatases targeting occludin.
J Biomed Biotechnol (2012) 2012, 807356

Dörfel MJ, Huber O
A phosphorylation hotspot within the occludin C-terminal domain.
Ann NY Acad Sci (2012) 1257, 38-44

Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PO, Moser C, Nielsen KF, Eberl L, Larsen TO, Tanner D, Hoiby N, Bjanrsholt T, Givskov M
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antitmicrob Agents Chemother (2012) 56, 2314-2325

Hackel D, Krug SM, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Bloch L, Kistner K, Amasheh S, Huber O, Blasig IE, Fromm M, Reeh PW, Brack A, Rittner HL
Analgesic drug delivery through a transiently opened perineural barrier in rats.
Proc Natl Acad Sci USA (2012) 109, E2018-E2027

Yang L, Chen Y, Cui T, Knösel T, Albring KF, Huber O, Petersen I
Desmoplakin has a tumor suppressive function through inhibition of Wnt/β-catenin signaling pathway in human lung cancer.
Carinogenesis (2012) 33, 1619-1624

Schulte J, Weidig M, Balzer P, Richter P, Franz M, Junker K, Gajda M, Friedrich K, Wunderlich H, Ostman A, Petersen I, Berndt A
Expression of the E-cadherin repressors Snail, Slug and Zeb1 in urothelial carcinoma of the urinary bladder: relation to stromal fibroblast activation and invasive behaviour of carcinoma cells.
Histochem Cell Biol (2012) 138, 847-860

Lauscher JC, Sefer E, Dullat S, Lipka S, Gröne J, Buhr HJ, Huber O, Kruschewski M
Increased Pontin expresssion is a potential predictor for outcome in sporadic colorectal carcinoma.
Oncol Rep (2012) 28, 1619-1624

Cui  T, Chen Y, Yang L, Knösel T, Huber O, Pacyna-Gengelbach M, Petersen I
The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer.
Carcinogenesis (2012) 33, 2326-2333

Dolle C, Westermann M, Schilli-Westermann M, Kirsch C
Influence of liposome composition and membrane binding on protein kinase activity of PI3Kg.
Biochem Biophys Res Commun (2011) 404, 968-973.

Zugowski C, Lieder F, Müller A, Gasch J, Corvinus FM, Moriggl R, Friedrich K
STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with teh MMP-1 promoter.
Biol Chem (2011) 392, 449-459.

Tsareva SA, Wagner S, Müller A, Corvinus FM, Friedrich K
Cell-cell contacts induce STAT3 activitiy in colon carcinoma cells through an autocrine loop.
J Cancer Res Clin Oncol (2011) 137, 857-863.

Blasig IE, Bellmann C, Cording J, del Vecchio G, Zwanziger D, Huber O, Haseloff RF
Occludin protein family - oxidative stress and reducing conditions.
Antioxid & Redox Signal (2011) 15, 1195-1219.

Cui T, Chen Y, Yang L, Knösel T, Zöller K, Huber O, Petersen I
DSC3 expression is regulated by p53, and methylation of DSC3 is a prognostic marker in human colorectal cancer.
Brit J Cancer (2011) 104, 1013-1019.

Wohlmann A, Sebastian K, Borowski A, Krause S, Friedrich K
Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function.
Biol. Chem. (2010) 391, 181-186

Westphal JK, Dörfel MJ, Krug SM, Cording JD, Piontek J, Blasig IE, Tauber R, Fromm M, Huber O
Tricellulin forms homomeric and heteromeric tight junctional complexes.
Cell Mol Life Sci; 67, 2057-2068.

Escher N, Ernst G, Melle C, Berndt A, Clement JH, Junker K, Friedrich K, Guntinas-Lichius O, von Eggeling F
Comparative proteomic analysis of normal and tumor stromal cells by tissue on chip based mass spectrometry (toc-MS).
Diagn Pathol (2010) 5:10

Capellino S, Cosentino M, Wolff C, Schmidt M, Grifka J, Straub RH
Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target.
Ann Rheum Dis. (2010) 69, 1853-1860

Pechkovsky DV, Prasse A, Kollert F, Engel KMY, Dentler J Luttmann W, Friedrich K, Müller-Quernheim J, Zissel G
Alternatively activatedalveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction.
Clin Immunol; 137, 89-101

Telleria-Diaz A*, Schmidt M*, Kreusch S, Neubert AK, Schache F, Vazquez E, Vanegas H, Schaible HG, Ebersberger A
Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids.
Pain (2010) 148, 26-35

Schmidt C, Schilli-Westermann M, Klinger R, Kirsch C
Phosphoinositide 3-kinase γ has multiple phospholipid binding sites.
The Protein Journal (2010) 29, 127-135

Entschladen F, Lindquist JA Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R, Friedrich K
Signal transduction - receptors, mediators, and genes. Sci Signal. 2, mr3 (2009)

Friedrich K, Lindquist JA, Entschladen F, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R
Signal transduction in the footsteps of Goethe and Schiller. Cell Commun. Signal. 7, 2 (2009)

Haefner J, Krieg C, Michel I, Weisser H, Friedrich K, Diel F
Th17 in sensitized human lymphocytes ex vivo? Inflamm Res. 58 Suppl 1, 75-76. (2009)

Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal J, Huber O, Schulzke JD, Fromm M
Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability.
Mol Cell Biol (2009) 20, 3713-3724

Schmidt M, Hartung R, Capellino S, Cutolo M, Pfeifer-Leeg A, Straub RH
Estrone/17 beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis.
Arthritis Rheum (2009) 60, 2913-2922

Funfak A, Hartung R, Cao J, Martin K, Wiesmüller KH, Wolfbeis OS, Köhler JM
Highly resolved dose-response functions for drug-modulated bacteria cultivation obtained by fluorometric and photometric flow-through sensing in microsegmented flow.
Sensors and Actuators B (2009) 142, 66-72

Huber O, Weiske J
Structure and function of desmosomes during apoptosis: is there an active contribution?
Research Signpost (2009) 63-86

Scholven J, Taras D, Sharbati-Tehrani S, Schön J, Gabler C, Huber O, Meyer zum Büschenfelde D, Blin N, Einspanier R
Intestinal expression of trefoil factors and related genes during postnatal development in a piglet probiotic trial.
Cell Physiol Biochem (2009) 23, 143-156

Dörfel MJ, Westphal JK, Huber O
Differential phosphorylation of occludin and tricellulin by CK2 and CK1.
Ann NY Acad Sci (2009) 1165, 69-73

Tapia R, Huerta M, Islas S, Avila-Flores A, Lopez-Bayghen E, Weiske J, Huber O, Gonzalez-Mariscal L
Zonula occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle.
Mol Biol Cell (2009) 20, 1102-1117

Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, Akcetin Z, Behrens J
Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor.
Mol Cell Biol (2009) 29, 1707-1718

Hermelink A, Kirsch C, Klinger R, Reiter G, Brezesinski G
Adsorption of GST-PI3Kg at the air-buffer interface and at substrate and nonsubstrate phospholipid monolayers.
Biophys J (2009) 96, 1016-25

Schwappacher R, Weiske J, Heining E, Ezerski V, Marom B, Henis YI, Huber O, Knaus P.
Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity.
EMBO J. (2009) 28, 1537-1550

Hartung R, Brösing A, Sczcepankiewicz G, Liebert U, Häfner N, Dürst M, Felbel J, Lassner D, Köhler JM
Application of an asymmetric helical tube reactor for fast identification of gene transcripts of pathogenic viruses by micro flow-through PCR.
Biomed Microdevices (2009) 1, 685-692

Ozegowski JH, Presselt N, Härtel A, Bocker T, Sänger J, Schmidt A, Willing K, Müller PJ
Anti-atherosclerotic effect of microbial hayluronate lyase from group B streptococci.
Pharmazie (2008), 63, 601-605

Borowski A, Kuepper M, Horn U, Knüpfer U, Zissel G, Höhne K, Luttmann W, Krause S, Virchow jr. JC, Friedrich K
Interleukin-13 promotes pro-fibrotic parameters in epithelia and fibroblasts of the human lung.
Clin Exp Allergy (2008) 38, 619-28

Dehner M, Hadjihannas M, Weiske J, Huber O, Behrens J
Wnt signaling inhibits forkhead box O3a-induced transcription and apoptosis through upregulation of serum- and glucocorticoid-inducible kinase 1.
J Biol Chem (2008) 283, 19201-19210

Cvačková Z*, Albring KF*, Koberna K, Ligasová A, Huber O, Raška I, Staněk D
Pontin is localized in nucleolar fibrillar centers. *equally contributed
Chromosoma (2008) 117, 487-497

Zahn C, Jaschke A, Weiske J, Hommel A, Hesse D, Augustin R, Lu L, Hong W, Florian S, Scheepers A, Joost HG, Huber O, Schürmann A
The ARF-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin.
J Biol Chem (2008) 283, 27179-27188

Huber O, Menard L, Haurie V, Nicou A, Taras D, Rosenbaum J
Pontin and Reptin, two related ATPases with multiple roles in cancer.
Cancer Res. (2008) 6873-6876

Dörfel M, Huber O
CSNK1A1 (casein kinase 1, alpha 1)
Atlas Genet Cytogenet Oncol Haematol. May (2008)

Huber O, Weiske J
Beta-Catenin takes a HIT.
Cell Cycle (2008) 7, 1326-1331

Rowe A*, Weiske J*, Kramer TS, Huber O, Jackson P
Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes. *equally contributed.
Neoplasia (2008) 10, 1421-1432

Schmidt M, Straub RH
Altered expression of 11 beta-hydroxysteroid dehydrogenases in rheumatoid arthritis synovial cells.
Arthritis Rheum (2007) 56(5), 1720-1721

Till O, Schmidt M, Linss W, Baumann E
Detection of bis(sulfosuccinimidyl) suberate binding in electrophoresis: Determination of membrane sidedness of proteins.
Electrophoresis (2007) 28(5), 740-745

Krause S, Schmoldt HU, Wentzel A, Ballmaier M, Friedrich K, Kolmar H
Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.
Febs J (2007) 274(1), 86-95

Knackmuss S, Krause S, Engel K, Reusch U, Virchow JC, Mueller T, Kraich M, Little M, Luttmann W, Friedrich K
Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha 1 chain.
Biol Chem (2007) 388(3), 325-330

Tsareva SA, Moriggl R, Corvinus FM, Wiederanders B, Schutz A, Kovacic B, Friedrich K
Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.
Neoplasia (2007) 9(4), 279-291

Lauscher JC, Loddenkemper C, Kosel L, Gröne J, Buhr HJ, Huber O
Increased Pontin expression in human colorectal cancer tissue.
Hum Pathol (2007) 38, 978-985

Weiske J, Albring KF, Huber O
The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activity.
Proc Natl Acad Sci. USA (2007) 51, 20344-20349

Dufour JF, Huber O, Kozma S, Lu X, Toftgard R
Tumour suppressors in liver carcinogenesis.
J Hepatol (2007) 47, 860-867

Meyer zum Büschenfelde D, Tauber R, Huber O
TFF-Peptide: Molekulare Wirkungsmechanismen und Eignung als diagnostischer Marker.
DGKL Klinische Chemie Mitteilungen (2007) 38, 2-7

Hertel W, Peschel G, Ozegowski JH, Müller PJ
Inhibitory effects of triterpenes and favonoids on the enzymatic activity of hayluronic acid-splitting enzymes.
Arch Pharm (2006) 339, 313-318

Mahmoodzadeh S, Eder S, Nordmeyer J, Ehler E, Huber O, Martus P, Weiske J, Pregla R, Hetzer R, Regitz-Zagrosek V
Estrogen receptor α upregulation and redistribution in heart failure.
FASEB J (2006) 20, 926-934

Weiske J, Huber O
The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.
J Biol Chem (2006) 281, 27356-27366

Wobus M, Huber O, Hamann J, Aust G
CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is regulated independently of the canonical Wnt pathway.
Mol Carcinogen (2006) 45, 881-886

Meyer zum Büschenfelde D, Tauber R, Huber O
TFF3 increases transepithelial resistance in epithelial cells by modulating claudin-1 and -2 expression.
Peptides (2006) 27, 3383-3390

Augsten M, Pusch R, Biskup C, Rennert K, Wittig U, Beyer K, Blume A, Wetzker R, Friedrich K, Rubio I
Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane.

EMBO Reports (2006) 7, 46-51 

Krause S, Behrends J, Borowski A, Lohrmann J, Lang S, Myrtek D, Lorenzen T, Virchow JC, Luttmann W, Friedrich K
Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor alpha 1.

Mol. Immunol. (2006) 43, 1799-807