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Homepage / Publications

BioImaging

Publications:    Pubmed

  1. Weiler S, Teichert M, Margrie TW (2024) Layer 6 coricocortical cells dominate the anatomical organization of intra and interhemispheric feedback, eLife. https://doi.org/10.7554/eLife.100478.1
  2. Graf J, Samiree A, Flossmann T, Holthoff K, Kirmse K (2024) Chemogenetic silencing reveals presynaptic Gi/o protein mediated inhibition of synchronized activity in the developing hippocampus in vivo. iScience. DOI: 10.1016/j.isci.2024.110997
  3. Teichert M, Gull S, Herrmann KH, Gaser C, Reichenbach JR, Urbach A, Frahm C, Holthoff K, Witte OW, Schmidt S (2024) Harnessing early multimodal motor training to drive motor recovery and brain-wide structural reorganization after stroke. bioRxiv doi: https://doi.org/10.1101/2024.07.03.601837
  4. Weiler S, Teichert M, Margrie TW (2024) Layer 6 corticocortical cells dominate the anatomical organization of intra and interhemispheric feedback. bioRxiv doi: https://doi.org/10.1101/2024.05.01.590702oRxiv
  5. Graf J, Samiree A, Flossmann T, Holthoff K, Kirmse K (2024) Chemogenetic silencing reveals presynaptic Gi/o protein mediated inhibition of synchronized activity in the developing hippocampus in vivo. bioRxiv doi: https://doi.org/10.1101/2024.02.02.578550
  6. Weiler S, Rahmati V, Isstas M, Wutke J, Stark AW, Franke C, Graf J, Geis C, Witte OW, Hübener M, Bolz J, Margrie TW, Holthoff K, Teichert M (2024) A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration. Nat Commun 15, 3081. https://doi.org/10.1038/s41467-024-47459-2
  7. Graf J, Rahmati V, Majoros M, Witte OW, Geis C, Kiebel SJ, Holthoff K, Kirmse K (2022) Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo. eLife 11:e82756. DOI: https://doi.org/10.7554/eLife.82756
  8. Weiler S, Rahmati V, Isstas M, Wutke J, Stark AW, Franke C, Geis C, Witte OW, Huebener M, Bolz J, Margrie TW, Holthoff K, Teichert M (2022) A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration. bioRxiv 2022.11.04.515161; doi: https://doi.org/10.1101/2022.11.04.515161 
  9. Graf J, Rahmati V, Majoros M, Witte OW, Geis C, Kiebel SJ, Holthoff K, Kirmse K (2022) Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo. bioRxiv doi: https://doi.org/10.1101/2021.05.28.446133
  10. Graf J, Zhang C, Marguet SL, Herrmann T, Flossmann T, Hinsch R, Rahmati V, Guenther M, Frahm C, Urbach A, Neves RM, Witte OW, Kiebel SJ, Isbrandt D, Hübner CA, Holthoff K, Kirmse K (2021) A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2014784118. doi: 10.1073/pnas.2014784118
  11. Seidel RA, Ritter M, Joerk A, Kuschke S, Langguth N, Schulze D, Görls H, Bauer M, Witte OW, Westerhausen M, Holthoff K, Pohnert G (2020) Photoisomerization neutralizes vasoconstricitve activity of a heme degradation product. ACS Omega 20;5(34):21401-21411. https://dx.doi.org/10.1021/acsomega.0c01698
  12. Graf J, Zhang C, Marguet SL, Herrmann T, Flossmann T, Hinsch R, Rahmati V, Guenther M, Frahm C, Urbach A, Neves RM, Witte OW, Kiebel SJ, Isbrandt D, Hübner CA, Holthoff K, Kirmse K (2020) Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network development in vivo. doi: https://doi.org/10.1101/2020.07.13.200014
  13. Kirmse K, Holthoff K (2020) Chloride transporter activities shape early brain circuit development, Book chapter in ´Neuronal Chloride Transporters in Health and Disease´, Academic Press, ISBN: 9780128153185
  14. Holthoff K (2020) The Janus-face of GABAergic synaptic transmission during brain development. J Physiol. doi: 10.1113/JP279623
  15. Zhang C, Yang S, Flossmann T, Gao S, Witte OW, Nagel G, Holthoff K, Kirmse K (2019) Optimized photo-stimulation of halorhodopsin for long-term neuronal inhibition. BMC Biology 17:95.
  16. Kirmse K (2019) Editorial: GABAergic networks in the developing and mature brain. Brain Res. 1718:10-11. doi: 10.1016/j.brainres.2019.04.029
  17. Joerk A, Ritter M, Langguth N, Seidel RA, Freitag D, Herrmann KH, Schaefgen A, Ritter M, Günther M, Sommer C, Braemer D, Walter J, Ewald C, Kalff R, Reichenbach JR, Westerhausen M, Pohnert G, Witte OW, Holthoff K (2019) Propentdyopents as heme degradation intermediates constrict mouse cerebral arterioles and are present in the cerebrospinal fluid of patients with subarachnoid hemorrhage. Circ Res. https://doi.org/10.1161/CIRCRESAHA.118.314160, commented by R. C. Koehler
  18. Flossmann T, Kaas T, Rahmati V, Kiebel SJ, Witte OW, Holthoff K, Kirmse K (2019) Somatostatin Interneurons Promote Neuronal Synchrony in the Neonatal Hippocampus, Cell Rep 26(12):3173-3182.e5, https://doi.org/10.1016/j.celrep.2019.02.061
  19. Prüss H, Kirmse K (2018) Pathogenetic role of autoantibodies against inhibitory synapses. Brain Res 1701:146-152. doi: 10.1016/j.brainres.2018.09.009.
  20. Haselmann H, Mannara F, Werner C, Planaguma J, Miguez-Cabalo F, Schmidl L, Grünewald B, Petit-Pedrol M, Kirmse K, Classen J, Demir F, Klöcker N, Soto D, Doose S, Dalmau J, Hallermann S and Geis C (2018) Human autoantibodies against the AMPA receptor subunit GluA2 induce receptor reorganisation and memory dysfunction. Neuron DOI: 10.1016/j.neuron.2018.07.048.
  21. Lukas M, Holthoff K, Egger V (2018) Long-Term Plasticity at the Mitral and Tufted Cell to Granule Cell Synapse of the Olfactory Bulb Investigated with a Custom Multielectrode in Acute Brain Slice Preparation. Methods Mol Biol 1820:157-167. doi: 10.1007/978-1-4939-8609-5_13.
  22. Rahmati V, Kirmse K, Holthoff K, Kiebel SJ (2018) Ultra-Fast Accurate Reconstruction of Spiking Activity from Calcium Imaging Data. J Neurophysiol doi: 10.1152/jn.00934.2017.
  23. Rahmati V, Kirmse K, Holthoff K, Schwabe L, Kiebel SJ (2017) Developmental Emergence of Sparse Coding: A Dynamic Systems Approach. Sci Rep 7:13015. DOI:10.1038/s41598-017-13468-z.
  24. Kirmse K, Hübner CA, Isbrandt D, Witte OW, Holthoff K (2017) GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages. The Neuroscientist. DOI: 10.1177/1073858417701382
  25. Kirmse K and Holthoff K (2017) Functions of GABAergic transmission in the immature brain. Neuroforum 23(1):A27–A33.
  26. Kummer M, Kirmse K, Zhang C, Haueisen J, Witte OW, Holthoff K (2016) Column-like Ca2+ clusters in the mouse neonatal neocortex revealed by three-dimensional two-photon Ca2+ imaging in vivo. Neuroimage 138, 64-75. doi:10.1016/j.neuroimage.2016.05.050.
  27. Rahmati V, Kirmse K, Markovic D, Holthoff K, Kiebel SJ (2016) Inferring neuronal dynamics from calcium imaging data using biophysical models and Bayesian inference. PLoS Comput Biol 12(2): e1004736. doi:10.1371/journal.pcbi.1004736
  28. Kummer M, Kirmse K, Witte OW, Haueisen J, Holthoff K (2015) A method to quantify accuracy of position feedback signals of a three-dimensional two-photon laser-scanning microscope. Biomed Opt Express 6(10):3678-3693.
  29. Popovic M, Vogt K, Holthoff K, Konnerth A, Salzberg BM, Grinvald A, Antic SD, Canepari M, Zecevic D (2015) Imaging Submillisecond Membrane Potential Changes from Individual Regions of Single Axons, Dendrites and Spines. Adv Exp Med Biol 859:57-101. doi: 10.1007/978-3-319-17641-3_3
  30. Kirmse K, Kummer M, Kovalchuk Y, Witte OW, Garaschuk O, Holthoff K (2015) GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo. Nat Commun 6:7750, doi:10.1038/ncomms8750
  31. Joerk A, Seidel RA, Walter S, Wiegand A, Kahnes M, Klopfleisch M, Pohnert G, Westerhausen M, Witte OW, Holthoff K (2014) Impact of heme and heme degradation products on vascular diameter in mouse visual cortex, JAHA, doi: 10.1161/JAHA.114.001220.
  32. Hübner CA and Holthoff K (2013). Anion transport and GABA signaling. Front Cell Neurosci 7:177. doi: 10.3389/fncel.2013.00177
  33. Kummer M, Kirmse K, Witte OW, Holthoff K (2012) Reliable in vivo identification of both GABAergic and glutamatergic neurons using Emx1-Cre driven fluorescent reporter expression, Cell Calcium 52: 182-189.
  34. Kirmse K, Witte OW, Holthoff K (2011) GABAergic depolarization during early cortical development and implications for anticonvulsive therapy in neonates, Epilepsia 52:1532-1543.
  35. Kirmse K, Witte OW, Holthoff K (2010) GABA depolarizes immature neocortical neurons in the presence of the ketone body ß-hydroxybutyrate, J Neurosci 30: 16002-16007.
  36. Holthoff K, Canepari M, Vogt C, Konnerth A, Zecevic D (2010) Dendritic voltage imaging, Imaging in Neuroscience and Development: A laboratory manual, Rafael Yuste, Fred Lanni and Arthur Konnerth (Eds.), Cold Spring Harbor Laboratory Press, in press.
  37. Canepari M, Popovic M, Vogt C, Holthoff K, Konnerth A, Salzberg BM, Grinvald A, Antic S, Zecevic D (2010) Imaging submillisecond membrane potential changes from individual regions of single axons, dendrites and spines, Membrane Potential Imaging in the Nervous System, Marco Canepari and Dejan Zecevic (Eds.), Springer, in press.
  38. Holthoff K,  Secevic D*, Konnerth A (2010) Rapid time-course of action potentials in spines and remote dendrites of mouse visual cortex neurons, J Physiol588: 1085-1096. (see Perspectives)
  39. Holthoff K* (2009) Calcium Imaging of dendrites and spines, Calcium Measurement Methods, Series: Neuromethods 43, Alexei Verkhratsky and Ole H. Petersen (Eds.), Humana Press
  40. Holthoff K*, Sagnak E, Witte OW (2007) Functional mapping of cortical areas with optical imaging, Neuroimage 37: 440-448.
  41. Johenning F, Holthoff K* (2007) Nuclear Calcium signals during L-LTP induction do not predict the degree of synaptic potentiation, Cell Calcium 41: 271-83.
  42. Holthoff K*, Kovalchuk Y, Konnerth A (2006) Dendritic spikes and activity-induced synaptic plasticity, Cell Tissue Res 326: 369-77.
  43. Holthoff K, Kovalchuk Y, Yuste R* , Konnerth A (2004) Single-shock LTD by local dendritic spikes, J Physiol 560: 27-36.
  44. Kovalchuk Y, Holthoff K, Konnerth A* (2004) Neurotrophin action on a rapid time scale, Curr Opin Neurobiol 14: 558-563.
  45. Holthoff K* (2004) Dendritic spikes and synaptic plasticity, Curr Neurovasc Res 1 (4): 269-281.
  46. Stosiek C, Garaschuk O, Holthoff K, Konnerth A* (2003) In vivo two-photon calcium imaging of neuronal networks. Proc Natl Acad Sci U S A 100: 7319-7324.
  47. Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F* (2003)  Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J 22: 216-224.
  48. Holthoff K*, Tsay D (2002) Calcium dynamics in spines: Link to synaptic plasticity, Exp Physiol  87.6, 725-731.
  49. Holthoff K*, Tsay D, Majewska A, Yuste R (2002) Response to 'Raising the speed limit - Fast calcium handling in dendritic spines', Trends Neurosci 25: 441.
  50. Goldberg J*, Holthoff K, Yuste R (2002) A Problem with Hebb and local spikes. Trends Neurosci 25: 433-435.
  51. Holthoff K*, Tsay D, Yuste R (2002) Calcium dynamics in spines depend on their dendritic location. Neuron, 33:425-437.
  52. Witte OW*, Niermann H, Holthoff K (2001) Cell swelling and ion redistribution assessed with      intrinsic optical signals. An Acad Bras Cienc 73: 337-35.
  53. Niermann H, Amiry-Moghaddam M, Holthoff K, Witte OW, Ottersen OP* (2001) A novel role of vasopressin in the brain: modulation of a radial, activity dependent water flux in the neocortex. J Neurosci, 21:3045-3051.
  54. Yuste R, Miller RB, Holthoff K, Zhang S, Miesenbock G* (2000) Synapto-pHluorins: chimeras between pH-sensitive mutants of green fluorescent protein and synaptic vesicle membrane proteins as reporters of neurotransmitter release. Methods Enzymol 327:522-546.
  55. Yuste R*, Majewska A, Holthoff K (2000) From form to function: calcium compartmentalization in dendritic spines. Nat Neurosci 3(7): 653-659.
  56. Holthoff K, Witte OW* (2000) Directed spatial potassium redistribution in rat neocortex. Glia,  29:288-292.
  57. Holthoff K, Witte OW* (1998) Intrinsic optical signals in vitro: a tool to measure alterations in extracellular space with two-dimensional resolution. Brain Res Bull 47:649-655.
  58. Holthoff K, Witte OW* (1997) Recording of neuronal network properties with near infrared dark field microscopy and microelectrodes. Electrochim Acta 42:3241-3246.
  59. Holthoff K, Witte OW* (1996) Intrinsic optical signals in rat neocortical slices measured with near-infrared dark-field microscopy reveal changes in extracellular space. J Neurosci 16:2740-2749.
  60. Holthoff K, Dodt HU, Witte OW* (1994) Changes in intrinsic optical signal of rat neocortical slices  following afferent stimulation. Neurosci Lett 180:227-230.
  61. Ott D, Holthoff K, Lades M, and Eckmiller R* (1990) Scanning laser ophthalmoscopy (SLO) - a new  tool in vision and oculomotor research. SPIE 1357:218-227.
  62. Ott D, Lades M, Holthoff K, Eckmiller R* (1990) A general numerical method evaluating  three-dimensional eye rotations by scanning laser ophthalmoscopy. Ophthalmic Physiol Opt 10:286-290.

* Corresponding author