Publikationen zur Methodik und Evaluation des DQS

Schwarzkopf D, Rüddel H, Brinkmann A, Fleischmann-Struzek C, Friedrich ME, Glas M, Gogoll C, Gründling M, Meybohm P, Pletz MW et al: The German Quality Network Sepsis: Evaluation of a Quality Collaborative on Decreasing Sepsis-Related Mortality in a Controlled Interrupted Time Series Analysis . Frontiers in Medicine 2022, 9:882340.

Schwarzkopf D, Rüddel H, Gründling M, Putensen C, Reinhart K: The German Quality Network Sepsis: study protocol for the evaluation of a quality collaborative on decreasing sepsis-related mortality in a quasi-experimental difference-in-differences design. Implement Sci 2018, 13(1):15.

Schwarzkopf D, Fleischmann-Struzek C, Rüddel H, Reinhart K, Thomas-Rüddel DO: A risk-model for hospital mortality among patients with severe sepsis or septic shock based on German national administrative claims data. PLOS ONE 2018, 13(3):e0194371.

Publikationen aus dem Vorläuferprojekt des DQS: Medical EDUcation for sepsis Source control and Antibiotics (MEDUSA)

Rüddel H, Thomas-Rüddel DO, Reinhart K, Bach F, Gerlach H, Lindner M, Marshall JC, Simon P, Weiss M, Bloos F et al: Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial. Crit Care 2022, 26(1):51.

Schwarzkopf D, Matthaeus-Kraemer CT, Thomas-Rüddel DO, Rüddel H, Poidinger B, Bach F, Gerlach H, Gründling M, Lindner M, Scheer C et al: A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis. Scientific Reports 2022, 12(1):3925.

Thomas-Rüddel DO, Hoffmann P, Schwarzkopf D, Scheer C, Bach F, Komann M, Gerlach H, Weiss M, Lindner M, Rüddel H et al: Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature. Crit Care 2021, 25(1):368.

Bloos F, Rüddel H, Thomas-Rüddel D, Schwarzkopf D, Pausch C, Harbarth S, Schreiber T, Gründling M, Marshall J, Simon P et al: Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med 2017, 43(11):1602 - 1612.

Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F: Crossing the handover chasm: Clinicians' perceptions of barriers to the early detection and timely management of severe sepsis and septic shock. J Crit Care 2016, 36:85-91.

Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F: Barriers and supportive conditions to improve quality of care for critically ill patients: A team approach to quality improvement. J Crit Care 2015, 30(4):685-691.

Thomas-Rueddel DO, Poidinger B, Weiss M, Bach F, Dey K, Häberle H, Kaisers U, Rüddel H, Schädler D, Scheer C et al: Hyperlactatemia is an independent predictor of mortality and denotes distinct subtypes of severe sepsis and septic shock. J Crit Care 2015, 30(2):439.e431-436.

Bloos F, Thomas-Ruddel D, Ruddel H, Engel C, Schwarzkopf D, Marshall JC, Harbarth S, Simon P, Riessen R, Keh D et al: Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study. Crit Care 2014, 18(2):R42.

Publikationen zur Sepsisepidemiologie

Fleischmann-Struzek C, Schwarzkopf D, Reinhart K: Inzidenz der Sepsis in Deutschland und weltweit: Aktueller Wissensstand und Limitationen der Erhebung in Abrechnungsdaten. Med Klin Intensivmed Notfmed 2022, 117(4):264–268.

Born S, Dame C, Matthäus-Krämer C, Schlapbach LJ, Reichert F, Schettler A, Schwarzkopf D, Thomas-Rüddel D, Proquitté H, Reinhart K et al: Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016. Crit Care Med 2021, 49(7):1049-1057.

Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz M, Gastmeier P, Reinhart K: Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med 2018, 44(11):1826-1835.

Fleischmann C, Thomas–Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Dennler U, Reinhart K: Fallzahlen und Sterblichkeitsraten von Sepsis-Patienten im Krankenhaus. Dtsch Arztebl International 2016, 113(10):159-166.

Publikationen zur Nutzbarkeit von Routinedaten für epidemiologische Surveillance und Qualitätsmanagement der Sepsis

Schwarzkopf D, Rose N, Fleischmann-Struzek C, Boden B, Dorow H, Edel A, Friedrich M, Gonnert F A, Götz J, Gründling M, Heim M, Holbeck K, Jaschinski U, Koch C, Künzer C, Ngoc K L, Lindau S, Mehlmann N B, Meschede J, Meybohm P, Ouart D, Putensen C, Sander M, Schewe J C, Schlattmann P, Schmidt G, Schneider G, Spies C, Steinsberger F, Zacharowski K, Zinn S, Reinhart K: Understanding the biases to sepsis surveillance and quality assurance caused by inaccurate coding in administrative health data. Infection. 2023 Sep 9. doi: 10.1007/s15010-023-02091-y.

Schwarzkopf D, Rose N, Fleischmann-Struzek C, Reinhart K: Ergebnisbericht: Validierung und Optimierung der Nutzbarkeit von Routinedaten zur Qualitätsverbesserung des Sepsis-Managements im Krankenhaus. 2022.

Schwarzkopf D, Fleischmann-Struzek C, Schlattmann P, Dorow H, Ouart D, Edel A, Gonnert FA, Götz J, Gründling M, Heim M et al: Validation study of German inpatient administrative health data for epidemiological surveillance and measurement of quality of care for sepsis: the OPTIMISE study protocol. BMJ Open 2020, 10(10):e035763.

Fleischmann-Struzek C, Thomas-Rüddel DO, Schettler A, Schwarzkopf D, Stacke A, Seymour CW, Haas C, Dennler U, Reinhart K: Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data. PLOS ONE 2018, 13(7):e0198847.

Wedekind L, Fleischmann-Struzek C, Rose N, Spoden M, Günster C, Schlattmann P, Scherag A, Reinhart K, Schwarzkopf D: Development and validation of risk-adjusted indicators for the long-term outcome of acute sepsis care in German hospitals based on health claims data. Front. Med. 2022, 9:1069042