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Start / Research / Research Profile / Sepsis and Infection

Sepsis and Infection

Sepsis is a life-threatening systemic infection with a high mortality of more than 50 % which affects people of all ages. In spite of the immense progress in modern clinical treatment and the exploration of the molecular biological basics, sepsis still presents a huge challenge for physicians and the health system. Clinical sepsis research aims to target lethality and morbidity as well as to improve prevention and after-care. To expand the knowledge of molecular mechanisms and of organ failure, experimental sepsis research combines clinical aspects with questions in fundamental research.

Research groups at JUH, or alliances JUH scientists are involved in:

  • Center for Sepsis Control & Care CSCC
    The Center for Sepsis Control & Care (CSCC) is one of eight Integrated Research and Treatment Centers funded by the Federal Ministry for Education and Research (Bundesministerium für Bildung und Forschung, BMBF). The CSCC is an institution at JUH and addresses sepsis research covering all aspects of the disease and its sequelae. Topics include risk assessment, prevention, and acute care as well as long-term sequelae and rehabilitation.
  • ZIK Septomics
    The Centre for Innovation Competence (ZIK) Septomics is a cross-faculty research centre of the Friedrich Schiller University Jena, and it is scientifically associated with Jena University Hospital and the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute. Septomics is taking an integrated research approach in order to end decades of stagnation in the field of sepsis research. Hence, basic researchers and physicians work closely together to develop a holistic model of sepsis. This will serve as a basis for new molecular diagnostic and therapeutic tools.
  • Clinical Research Group Infectious Disease 
    The group with the Center for Infection Medicine and Hospital Hygiene is funded by BMBF. It deals with new strategies against infections caused by multi-resistant pathogens.

  • Smart Medical Information Technology for Healthcare (SMITH)

    Within the Medical Informatics Funding Scheme of the Federal Ministry of Education and Research (BMBF), the university hospitals in Aachen, Jena, Leipzig, Hamburg, Bonn, Essen and Halle are involved and funded. Their aim within the scope of SMITH is the development of an innovative structure for cross-institutional linking and exchange of healthcare and research data between sites and beyond.

  • DFG Research Unit (RU) “Synaptic pathology in autoimmune encephalitis” (SYNABS)

    The group brings together clinician scientists in the field of antibody-mediated immunological disorders with basic scientists in the field of neurophysiology, molecular neurobiology, and neuroimmunology collectively investigating autoantibody-mediated pathology in the CNS.

  • SepNet
    The Sepsis Competence Network Sepsis, that has existed since 2002, is continued as a study goup.
  • FungiNet - Integrated Research on human-pathogenic fungi - Würzburg/Jena
    Two sub-projects of the CRC are lead by JUH scientists.
  • Research Campus InfectoGnostics
    The InfectoGnostics research campus is a public-private partnership developing new methods in infection diagnostics. In a triad of technology, application and production, more than 30 partners from science, medicine and industry are developing marketable solutions for rapid and cost-effective on-site analysis (point-of-care testing) of infection

  • InfectControl 2020InfectControl 2020 is a consortium of representatives from enterprises and academia that jointly aims at developing solutions regarding these problems on a national and global level. Proposals for solutions are being developed within the scope of the funding programme „Zwanzig20 – Partnerschaft für Innovation“ headed by BMBF. With InfectControl 2020, a highly innovative research alliance has been established that aims at developing and commercially implementing basically new strategies for the early recognition, the control and successful approaches to fight infectious diseases.

Further information and partners: