Principal investigator: apl. Prof. Dr. Yasser Sakr
DFG 2018 - 2022
Projektleiterin: Prof. Dr. Britta Qualmann
DFG 2020-2020
Currently available data indicate that albumin supplementation during severe and prolonged sepsis may provide survival benefits. To date, an adequate evaluation of this effect in a prospective randomized trial has not been performed. ARISS aims to assess the influence of albumin replacement on the maintenance of albumin serum levels after onset of septic shock compared to volume replacement therapy without albumin on patient survival.
DRKS00017475
NCT03869385
Principal investigators: PD Dr. Sebastian Weis, Prof. Dr. Michael Bauer
EU 2020-2023
In this project, approaches to personalized immuno-therapy for sepsis patients are investigated. As a basis, biomarkers for the prediction of individual disease courses explored. These markers will inform the individual adaptation of treatment for each patient, e.g. stimulation vs. dampening of the immune response. The trial aims to include about 300 patients in six European countries. Jena is the only clinical trial center in Germany.
www.immunosep.eu
Principal investigator: Prof. Dr. Dr. Sina Coldewey
BMBF (ZIK Septomics) 2016 - 2021
Sepsis survivors often suffer from substantial health impairments. In this trial, cardiovascular function, oxygen consumption and metabolic changes in sepsis patients (incl. COVID-19 sepsis) are monitored, from the acute phase until one year after onset of disease. The data will be used to identify clinical and molecular parameters that influence septic disease courses as well as medium- and long-term sequelae. The aim of the study is the development of novel diagnostic and therapeutic approaches.
NCT03620409
https://www.septomics.de/en/klinische-studien.html
Principal investigator: PD Dr. Dr. Petra Dickmann
Staatskanzlei Thüringen 2020 - 2021
Under the enormous pressure of the Corona pandemic since 2020, rational criteria are often missing to regulate easing of containment measures without overstretching the health system. Adequate science-based criteria are thus developed in the research group Pandemic Management. Improved understanding and documentation of disease burden, constant survey of health system capacities and the evaluation of consequences of the pandemic for the general public are crucial to this end.
Principal investigator: apl. Prof. Dr. Winfried Meißner
seit 2006
QUIPS is a multicentric, interdisciplinary benchmarking project that aims to improve therapy of acute pain in operative centres and hospitals in Germany. Standardized assessment of quality indicators, their analysis and feedback to participating hospitals help to improve outcomes of post-operative pain therapy. The international equivalent is the project PAIN OUT. With over 650.000 datasets and around 200 participating hospitals, the two projects provide the largest database on acute pain worldwide.
Principal investigator: apl. Prof. Dr. Winfried Meißner
EU (IMI 2, Horizon 2020) 2018 - 2023
PROMPT aims at improving management of acute and chronic pain by identifying a core set of PROMs (patient reported outcome measures) that are predictive indicators of treatment success in clinical routine as well as in studies. These will not only address pain intensities and functional consequences of pain but also side effects. In addition, it will be investigated if these PROMs can help to identify patients at risk of experiencing chronification of acute post-operative pain.
Homepage of the project
