Conservative dentistry as tooth preservation includes the treatment of diseases of the tooth root (endodontology), diseases of the gums (periodontics) and the restoration of loss of enamel and dentin caused by caries and / or erosions. As standard, we use state-of-the-art biomaterials for hard tissue replacement in the context of modern filling techniques, e.g. composite and ceramic, and modern methods of therapy, such as laser treatment.

Prof. Dr. Dr. Bernd W. Sigusch
An der alten Post 4
07743 Jena

Conservative Dentistry and Periodontology

Research projects

Development of an antibacterial photodynamic system and technique for prevention of ventilator associated pneumonia

Principal investigator: Prof. Dr. Dr. Bernd W. Sigusch
TAB 2017 - 2020

The aim of the research project was to identify the microbial biofilm profiles of endotracheal tubes in patients with ventilator associated pneumonia. The results were used for the development of a photodynamic based treatment procedure of the oral and pharyngeal region for prevention purpose.

Development and testing of a foamable polyurethane composite with organic and anorganic additives for the treatment of periodontal and periimplant bone lesions

Principal investigator: Prof. Dr. Dr. Bernd W. Sigusch
BMWi (ZIM) 2020-2022

The aim of this research project is to develop of a foamable synthetic material for the treatment of periodontal and periimplant bone lesions. Further the material is thought to stabilize teeth. In addition it should be provided with an antibacterial component for the suppression of residual bacteria of the lesion in order to prevent the re-infection

Infection of the root canal system by E. faecalis

Principal investigator: Prof. Dr. Dr. Bernd W. Sigusch

2020 - 2021

The aim of the project was to develop a methodology for observing the infection of the root canal and the dentinal tubules by Enterococcus faecalis. The results will help to determine the efficiency of antibacterial substances and treatment strategies to supress the species that have penetrated far into the dentin system.

Mesenchymal mechanisms and dietary targeting of inflammatory bone loss caused by bacterial colonization and infection

Subproject of MESINFLAME: Integrative preclinical strategies for targeting the local mesenchyme as a regulator of tissue specificity in inflammatory musculoskeletal disorders

Principal investigator: PD Dr. Ulrike Schulze-Späte
BMBF 2020 - 2023

Periodontitis is a bacterial-induced inflammatory disease of tooth-supporting tissue that is characterized by progressive loss of bone and periodontal attachment. The project aims to identify key mesenchymal signaling pathways that induce inflammatory bone loss. Further, we want to localize therapeutic targets within the mesenchyme that could be used to modulate and potentially reverse the onset and extent of tissue loss.

Retrospective analysis of clinical outcomes after recession coverage

Principal investigator: PD Dr. Ulrike Schulze-Späte
Geistlich Pharma AG 2019 - 2021

Comparison of Clinical Outcomes after Root Coverage using Modified Vestibular Incision Subperiosteal Tunnel Access Procedure with Volume-Stable Collagen Matrix and Coronally Advanced Flap (Full Thickness and Partial Thickness) in Combination with Subepithelial Connective Tissue Graft: a Retrospetive Analysis.

Selected publications

Kranz S, Guellmar A, Olschowsky P, Tonndorf-Martini S, Heyder M, Pfister W, Reise M, Sigusch B. Antimicrobial Effect of Natural Berry Juices on Common Oral Pathogenic Bacteria. Antibiotics. 2020 Aug 24;9(9):533.
Guentsch A, Fahmy MD, Wehrle C, Nietzsche S, Popp J, Watts DC, Kranz S, Krafft C, Sigusch BW. Effect of biomimetic mineralization on enamel and dentin: A Raman and EDX analysis. Dent Mater. 2019 Sep;35(9):1300-1307
Kranz S, Guellmar A, Voelpel A, Lesser T, Tonndorf-Martini S, Schmidt J, Schrader C, Faucon M, Finger U, Pfister W, Diefenbeck M, Sigusch B. Bactericidal and Biocompatible Properties of Plasma Chemical Oxidized Titanium (TiOB®) with Antimicrobial Surface Functionalization. Materials. 2019 Mar 15;12(6):866.
Bittner N, Schulze-Späte U, Cleber S, Da Silva J, Kim D, Tarnow D, Gil M., Ishikawa-Nagai S. Changes of the alveolar ridge dimension and recession associated with imlant position and tissue biotype with immediate implant placement: a randomized controlled clinical trial. Int J Oral Implantol 2019;12(4):1–12.
Bittner N, Planzos L, Volchonok A, Tarnow D, Schulze-Späte U. Evaluation of horizontal and vertical buccal ridge dimensional changes after immediate implant placement and immediate temporization with and without bone augmentation procedures. Short-term, 1 year result. A randomized controlled clinical trial. Int J Periodontics Restorative Dent. Jan/Feb 2020;40(1):83-93.

Outstanding achievements

Practice meets clinic -2019 - 140 years of endodontic antiseptics (1879 - 2019) in Jena
"The antiseptic treatment of pulp diseases of the tooth" - A. Witzel

November 2019, a further Symposium Practice-Meets-Clinic took place with 40 participants from the middle of Germany. Based on five scientific professional lectures , one of them associated with the founder of the Jena dental clinic Prof. Witzel, results of modern new diagnostic procedures and antimicrobial treatment procedures of the root canal system were presented.

Poster and presentation awards

Arbeitsgemeinschaft für Grundlagenforschung 2020 Poster Award: Boelter A, Döding A, Michler F, Maghames A, Zimmermann S, Iffarth V, Bastian A, Hennig C-L, Jacobs C, Sigusch B, Schulze-Späte U. Einfluss von Fettquantität und –qualität auf Knochenstoffwechsel und Inflammation bei Parodontitis.
Deutsche Gesellschaft für Parodontologie 2019 Short Presentation Award: Zimmermann S, Döding A, Iffarth VK, Michler F, Maghames A, Bastian A, Sigusch B, Schulze-Späte U. Einfluss der Ernährung auf das inflammatorische Risiko und den systemischen Knochenstoffwechsel bei Parodontitis.
Deutsche Gesellschaft für Parodontologie 2019 Poster Award: Döding A, Zimmermann S, Bölter A, Iffarth VK, Michler F, Maghames A, Bastian A, Sigusch B, Schulze-Späte U. Fettquantität oder -qualität? Modifikationen von Knochenstoffwechsel und Inflammation bei Parodontitis.
Arbeitsgemeinschaft für Grundlagenforschung 2019 Poster Award : Döding A, Iffarth VK, Michler F, Zimmermann S, Maghames A, Bastian A, Wolf M, Sigusch B, Schulze-Späte U. Unterschiedliche Reaktionen auf eine P. gingivalis- Infektion in Abhängigkeit vom Alter.