At the Institute for Diagnostic and Interventional Radiology patients are offered the complete diagnostic spectrum of the most advanced imaging technology at the highest level. As one of the first university radiologies we use Artificial Intelligence (AI) for image reconstruction on CT in routine radiology.

Also four computer tomographs, five magnetic resonance tomographs and three angiography systems as well numerous ultrasound and X-ray devices are available for fast and modern patient care.

Prof. Dr. Ulf Teichgräber
Am Klinikum 1
07747 Jena

Institute of Diagnostic and Interventional Radiology

Research projects

Use and reuse of MRI data in biomedical research

Principal investigators: Prof. Jürgen R. Reichenbach, Dr.-Ing. Daniel Güllmar
Carl-Zeiss Stiftung 2019 - 2024

The aim of the project is to develop new holistic and contrast-independent methods for assessing the data quality of MR data using deep learning. The sub-objectives are the identification of artifact-free data sets; the detection of potential bias factors in the data sets; the correction of these factors; and the implementation of so-called image-derived phenotypes (IDPs). A future field of application of these approaches may be the estimation of the course of a disease based on the available knowledge.

RACOON-COVID-19: RAdiological COOperative Network to COVID-19 pandemic

within the German University Medicine Network Covid-19 (NUM)

Principal investigators: Felix V. Güttler, Prof. Dr. Ulf Teichgräber
BMBF 2020 - 2021

In Covid-19 pandemic, radiological data play a key role in diagnostics and process assessment. RACOON will be the first project of this magnitude worldwide to set up an infrastructure for the structured collection of such data. In the future, numerous services such as epidemiological early warning systems or medical assistance systems based on artificial intelligence will be connected.

NoCanTher: Nanomedicine upscaling for early clinical phases of multimodal cancer therapy

Principal investigator: apl. Prof. Dr. Ingrid Hilger
EU 2016 - 2021

The consortium NoCanTher aims to scale-up under Good Manufacturing Practice (GMP) conditions a magnetic nanoparticle formulation based on iron oxide from the pre-clinical laboratory scale to the quantity needed for clinical testing. It is the goal to translate the nanoformulations against pancreatic ductal adenocarcinoma to an early clinical development. The combination of the particles and the magnetic field at the tumoral area will increase the temperature inducing the death of tumoral cells.

Project homepage: http://www.nocanther-project.eu/

Development of MR based technologies for non-invasive in vivo characterization of mechanical load in tissues

Motion and straining of soft-tissues in the knee

Principal investigator: Prof. Dr. Jürgen R. Reichenbach
DFG 2017 - 2021

The aim of the project is to determine stresses (stretching of the soft tissue structures) and their (dynamic) changes in passive and active movement in vivo by means of MRI-based, dynamic imaging. Using the knee joint as a representative example, it is intended to show how movement of the joint on the one hand and stress on the structures on the other hand interact. In particular, the soft tissues that span the joint will be processed so that the strains can be visualized and quantified as a correlate of the acting stresses.

Effects of emotion-focused vs. cognitive interventions of schema therapy on emotion regulation deficits in females suffering borderline personality disorder

Interrelations between clinical efficacy, connectivity in the executive control and salience network and local glutamate/GABA metabolism

Principal investigator: Prof. Dr. Jürgen R. Reichenbach
DFG 2017 - 2021

The aim of this cooperation project with the Department of Psychiatry and Psychotherapy (Prof. S. Smesny) is to compare effects of emotion-focused and cognitive interventions of schema therapy in females with borderline personality disorder by using resting-state functional MR imaging (rs-fMRI) and MR spectroscopy.

Further projects

Characterization of tissue parameters of tendons and ligaments by noninvasive magnetic resonance imaging using ultrashort echo times

Principal investigators: Prof. Dr. Jürgen R. Reichenbach; Marta Maggioni (scholarship holder)

Graduate academy 2020 – 2023
Ein auf dem Magnetisierungs-Sättigungs-Transfer basiertes Bildgebungsverfahren, als lokalisierte „omics“ Technologie

Principal investigator: PD Dr. Verena Hörr

FSU ProChance 2020 - 2022
Relevance Analysis of Deep Learning Methods for the classification of biomedical imaging data

Principal investigators: Prof. Dr. Jürgen R. Reichenbach, Dr.-Ing. Daniel Güllmar

FSU 2020 - 2021
Magnetic Properties of Normal Appearing Brain White Matter in Multiple Sclerosis

Principal investigator: Prof. Dr. Jürgen R. Reichenbach

DFG 2016 - 2021

Investigator initiated trials

EFFPAC: Effectiveness of Paclitaxel-coated Luminor® Balloon Catheter Versus Uncoated Balloon Catheter in the Arteria Femoralis Superficialis

Principal investigator: Prof. Dr. Ulf Teichgräber

NCT02540018 2015 - 2022
-> Pr ess release
SIRONA: Sirolimus- vs. Paclitaxel-Drug Coated Ballons in Patients With Peripheral Artery Disease
Principal investigator: Prof. Dr. Ulf Teichgräber

NCT04475783 2020 - 2027
LIMES: Comparative study of SiroLIMs-coated vs. uncoated balloon angioplasty in patients with PAD in the lower leg

Principal investigator: Prof. Dr. Ulf Teichgräber

2021 - 2028

Selected publications

Teichgräber U, Lehmann T, Aschenbach R, Scheinert D, Zeller T. Drug-coated Balloon Angioplasty of Femoropopliteal Lesions Maintained Superior Efficacy over Conventional Balloon: 2-year Results of the Randomized EffPac Trial. Radiology 2020 May;295(2):478-487.
Teichgräber U, Lehmann T, Aschenbach R, Thieme M, Zeller T, Beschorner U, Scheinert D. Two-year Review on Mortality and Morbidity after Femoropopliteal Drug-coated Balloon Angioplasty in the Randomized EffPac Trial. Radiology. 2020 Jul 21; 201370. doi: 10.1148/radiol.2020201370
Tansi F, Rüger R, Böhm C, Steiniger F, Teichgräber U, Fahr A, Hilger I. Rapid Target Binding and Cargo Release of Activatable Liposomes Bearing HER2 and FAP Single-Chain Antibody Fragments Reveal Potentials for Image-Guided Delivery to Tumors Pharmaceutics. 2020 Oct 15;12(10):972. doi: 10.3390/pharmaceutics12100972.
Piehler S, Wucherpfennig L, Tansi F, Berndt A, Quaas R, Teichgraeber U, Hilger I. Hyperthermia affects collagen fiber architecture and induces apoptosis in pancreatic and fibroblast tumor hetero-spheroids in vitro Nanomedicine. 2020 Aug;28:102183. doi: 10.1016/j.nano.2020.102183. Epub 2020 Mar 25.
Heinrich A, Güttler FV, Schenkl S,Teichgräber UK. Automatic human identification based on dental X-ray radiographs using computer vision. Sci Rep. 2020 Mar 2;10(1):3801. doi: 10.1038/s41598-020-60817-6. PMID: 32123249; PMCID: PMC7051975.

Outstanding achievements

The medical student council of the Friedrich Schiller University honored Prof. Dr. Ulf Teichgräber for his commitment to teaching with the Janus-Cornarius Prize 2020.