Institute of Physiology 1 - Neurophysiology
Research projects
Impact of neuroinflammation and neurodegeneration on brain and spinal homeostasis: relevance to nociception
Principal investigator: apl. Prof. Dr. Frank Richter
EU 2018 - 2022
We investigate in this project the impact of neuroinflammation on the homeostasis in the brain and the spinal cord. We address how neuropeptides and cytokines relevant for nociception, and the pathology of Morbus Alzheimer, change homeostasis, and modify brain functions.
The role of interleukin-17 and interferon-γ in the generation of arthritic pain
Principal investigator: Prof. Dr. Hans-Georg Schaible
DFG 2015-2019
In this project, we explore specifically the role of interleukin-17 and interferon-γ in the generation and maintenance of arthritic pain. Research is carried out on the molecular, cellular and systemic level.
Mechanisms of spinal neuroinflammation and hyperexcitablilty in joint inflammation
Principal investigators: PD Dr. Andrea Ebersberger, Prof. Dr. Hans-Georg Schaible
EU 2018 - 2022
We investigate the cooperation of spinal neurons and glial cells in the induction of central sensitization. The focus is on the central role of the spinal IL-6 cascade.
The role of Interleukin-6 in osteoarthritis pain and for homeostasis of chondrozytes
Principal investigators: Prof. Dr. Hans-Georg Schaible, Dr. Annett Eitner
DFG 2020 - 2023
In this project the Institute of Physiology 1 and the Clinic for Trauma-, Hand- and Reconstructive Surgery investigate the role of Interleukin-6 for the generation of osteoarthritis pain and the homeostasis of chondrocytes.
Treatment options of chronic arthritic pain
Principal investigator: Prof. Dr. Hans-Georg Schaible
BMBF 2015 - 2020
In this project, we explore which pharmacologic strategies can be used to effectively reduce the pain in the course of chronic joint diseases. We investigate the basic mechanisms of pain generation in articular diseases and we study which of these mechanisms can be used for analgesic treatment.
Further projects
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EP3 receptor signaling in nociceptive sensory neurons
Principal investigator: Dr. Christian König
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Regulation of TRP channels in neurons and chondrocytes
Principal investigator: PD Dr. Gisela Segond von Banchet
Selected publications
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Leuchtweis J, Segond von Banchet G, Eitner A, Ebbinghaus M, Schaible HG. Pain-related behaviors associated with persistence of mechanical hyperalgesia after antigen-induced arthritis in rats. Pain 2020; 161(7):1571-1583
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Ebbinghaus M, Müller S, Segond von Banchet G, Eitner A, Wank I, Hess A, Hilger I, Kamradt T, Schaible HG. Contribution of Inflammation and Bone Destruction to Pain in Arthritis: A Study in Murine Glucose-6-Phosphate Isomerase-Induced Arthritis. Arthritis Rheumatol. 2019;71(12):2016-2026
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Richter F, Segond von Banchet G, Schaible HG. Transient Receptor Potential vanilloid 4 ion channel in C-fibres is involved in mechanonociception of the normal and inflamed joint. Sci Rep. 2019; 29;9(1):10928
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Ebbinghaus M, Tuchscherr L, Segond von Banchet G, Liebmann L, Adams V, Gajda M, Hübner CA, Kurth I, Schaible HG. Gain-of-function mutation in SCN11A causes itch and affects neurogenic inflammation and muscle function in Scn11a+/L799P mice. PLoS One. 2020; 20;15(8):e0237101
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Lehmenkühler A, Richter F. Cortical Spreading Depolarization (CSD) Recorded from Intact Skin, from Surface of Dura Mater or Cortex: Comparison with Intracortical Recordings in the Neocortex of Adult Rats. Neurochem Res. 2020;45(1):34-41
Outstanding achievements
In October 2020, Prof. Schaible became the President-elect of the German Pain Society. He will be President in the period 2023/2024. In cooperation with Professor Esther Pogatzki-Zahn (Münster), he edited the volume “Pain” of The Senses: A Comprehensive Reference, Elsevier Academic Press 2020.