2021

• Abdulazeez M, Kankel S, Liehr T. About the origin of the acrocentric part of non-acrocentric satellited chromosomes in humans. Research Results Biomedicine 2021, 7:215-219.
• Alarbeed IF, Wafa A, Moassass F, Al-Halabi B, Al-Achkar W, Liehr T, Aboukhamis I. De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report. J Med Case Rep 2021, 15:22.
• Azawi S, Rincic M, Liehr T. Cytogenomic characteristics of murine breast cancer cell line JC. Mol Cytogenet 2021, 14:7.
• Azawi S, Piaszinski P, Balachandran M, Liehr T, Rincic M. Molecular cytogenomic characterization of two murine liver cancer cell lines: MH-22A and Hepa 1-6. J Genet Genomes 2021, 5:1
• Azawi S, Barf L-M, Liehr T. First molecular cytogenetic characterization of the MMT 060562 murine breast cancer cell line. Research Results Biomedicine 2021, 7: 4-14.
• Azawi S, Liehr T, Rincic M. First molecular cytogenetic characterisation of tracheal squamous cell carcinoma cell line KLN 205. J Cancer Metast Treatm 2021, 7:38.
• Bartsch S, Mirzakhani K, Neubert L, Stenzel A, Ehsani M, Esmaeili M, Pungsrinont T, Kacal M, Rasa SMM, Kallenbach J, Damodaran D, Ribaudo F, Grimm MO, Neri F, Baniahmad A. Antithetic hTERT regulation by androgens in prostate cancer cells: hTERT inhibition is mediated by the ING1 and ING2 tumor suppressors. Cancers (Basel). 2021, 13: 4025.
• Behrends M, Engmann O. Loop interrupted: Dysfunctional chromatin relations in neurological diseases. Front Genet 2021, 12: 732033.
• Burghardt K, Baba N, Schreyer I, Graneß I, Hübner CA. STX1B-related epilepsy in a 24-month-old female infant. Epilepsy Behav Rep 2021; 15:100391.

• Chaiyasan P, Mingkwan B, Jantarat S, Suwannapoom C, Cioffi MdB, Liehr T, Talumphaim S, Tanomtong A, Supiwong W. Classical and molecular cytogenetics of Belontia hasselti (Perciformes: Osphronemidae): Insights into the ZZ/ZW sex chromosome system. Biodiversitas 2021, 22:546-554.

• Coci EG, Koehler U, Liehr T, Stelzner A, Fink C, Langen H, Riedel J. Correction to: CANPMR syndrome and chromosome 1p32-p31 deletion syndrome coexist in two related individuals affected by simultaneous haplo-insufficiency of CAMTA1 and NFIA genes. Mol Cytogenet 2021;14:17. Erratum for: Mol Cytogenet 2016; 9:10.

• de Moraes RLR, Sassi F de MC, Bertollo LAC, Koh MM, Viana PF, Feldberg E, Oliveira VCS, Deon GA, Al-Rikabi ABH, Liehr T, Cioffi M de B. Tracking the evolutionary trends among small-sized fishes of the genus Pyrrhulina (Characiformes, Lebiasinidae): New insights from a molecular cytogenetic perspective. Front Genet 2021, 12: 769984

• Ditcharoen S, Khensuwan S, Seetapan K, Soonthornvipat P, Suwannapoom C, Pinthong K, Tongnunui S, Cioffi MdB, Liehr T, Tanomtong A, Supiwong W. First classical and molecular cytogenetic analyses of Sperata acicularis (Siluriformes, Bagridae). Taiwania 2021, 66: 203-213.

• Ehsani M, David FO, Baniahmad A. Androgen receptor-dependent mechanisms mMediating drug resistance in prostate cancer. Cancers (Basel). 2021, 13:1534.

• Engmann O. How psychoactive drugs and the circadian clock are enlightening one another. Adv Exp Med Biol 2021, 1344:129-152.
• Franzka P, Krüger L, Schurig MK, Olecka M, Hoffmann S, Blanchard V, Hübner CA. Altered glycosylation in the aging heart. Front Mol Biosci. 2021;8:673044.

• Franzka P, Henze H, Jung MJ, Schüler SC, Mittag S, Biskup K, Liebmann L, Kentache T, Morales J, Martínez B, Katona I, Herrmann T, Huebner AK, Hennings JC, Groth S, Gresing LJ, Horstkorte R, Marquardt T, Weis J, Kaether C, Mutchinick OM, Ori A, Huber O, Blanchard V, von Maltzahn J, Hübner CA. GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation. J Clin Invest 2021; 23:139076.

• Fuchs S, Lisfeld J, Kankel S, Person L, Liehr T. The acrocentric part of der(Y)t(Y;acro)(q12;p1?2) contains D15Z1 sequences in the majority of cases. Hum Genome Var 2021, 8:32.
• Garbade SF, Zielonka M, Komatsuzaki S, Kölker S, Hoffmann GF, Hinderhofer K, Mountford WK, Mengel E, Sláma T, Mechler K, Ries M. Quantitative retrospective natural history modeling for orphan drug development. J Inherit Metab Dis. 2021, 44:99-109.
• Ghafouri-Fard S, Khoshbakht T, Hussen BM, Kadkhoda S, Taheri M, Tafrishinejad A. A review on the role of miR-149-5p in the carcinogenesis. IntJ Mol Sciences 2021; 23: 415.
• Graf J, Zhang C, Marguet SL, Herrmann T, Flossmann T, Hinsch R, Rahmati V, Guenther M, Frahm C, Urbach A, Neves RM, Witte OW, Kiebel SJ, Isbrandt D, Hübner CA, Holthoff K, Kirmse K. A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior. Proc Natl Acad Sci U S A. 2021, 118:e2014784118.
• Grigoryan A, Pospiech J, Krämer S, Lipka D, Liehr T, Geiger H, Kimura H, Mulaw MA, Florian MC. Attrition of X chromosome inactivation in aged hematopoietic stem cells. Stem Cell Reports. 2021 Apr 13;16(4):708-716.

• Heinze K, Hölzer M, Ungelenk M, Gerth M, Thomale J, Heller R, Morden CR, McManus KJ, Mosig AS, Dürst M, Runnebaum IB, Häfner N. RUNX3 transcript variants have distinct roles in ovarian carcinoma and differently influence platinum sensitivity and angiogenesis. Cancers (Basel) 2021;13:476.

• Hochstenbach R, Liehr T, Hastings RJ. Chromosomes in the genomic age. Preserving cytogenomic competence of diagnostic genome laboratories. Europ J Hum Genet 2021, 29:541-552.
• Imarazene B, Du K, Beille S, Jouanno E, Feron R, Pan Q, Torres-Paz J, Lopez-Roques C, Castinel A, Gil L, Kuchly C, Donnadieu C, Parrinello H, Journot L, Cabau C, Zham M, Klopp C, Pavlica T, Al-Rikabi A, Liehr T, Simanovsky S, Bohlen J, Sember A, Perez J, Veyrunes F, Mueller T, Postlethwait J, Schartl M, Herpin A, Rétaux S, Guiguen Y. A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus. Curr Biol 2021, 31: 4800-4809.e9.

• Kadioglu O, Saeed MEM, Mahmoud N, Azawi SSH, Rincic M, Liehr T, Efferth T. Identification of metastasis-related genes by genomic and transcriptomic studies in murine melanoma. Life Sciences 2021, 267:11892.

• Kadioglu O, Saeed M, Mahmoud N, Azawi S, Mrasek K, Liehr T, Efferth T. Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion. Arch Toxicol 2021, 95:959-974.

• Kadioglu O, Saeed MEM, Mahmoud N, Azawi S, Mrasek K, Liehr T, Efferth T. Identification of novel drug resistance mechanisms by genomic and transcriptomic profiling of glioblastoma cells with mutation-activated EGFR. Life Sciences 2021, 284: 119601.

• Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al (incl. Hübner CA). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021; 17:1-382.

• Khundadze M, Ribaudo F, Hussain A, Stahlberg H, Brocke-Ahmadinejad N, Franzka P, Varga RE, Zarkovic M, Pungsrinont T, Kokal M, Ganley IG, Beetz C, Sylvester M, Hübner CA. Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. Autophagy 2021; 9:1-17.
• Koltsova AS, Efimova OA, Malysheva OV, Osinovskaya NS, Liehr T, Al-Rikabi A, Shved NY, Sultanov IY, Chiryaeva OG, Yarmolinskaya MI, Polenov NI, Kunitsa VV, Kakhiani MI, Tral TG, Tolibova GK, Bespalova ON, Kogan IY, Glotov AS, Baranov VS, Pendina AA. Cytogenomic profile of uterine leiomyoma: in vivo vs in vitro comparison. Biomedicines 2021, 9: 1777.
• Liehr T. Repetitive elements in human. Int J Mol Sci 2021, 22:2072 - also available at https://encyclopedia.pub/8533
• Liehr T. About classical molecular genetics, cytogenetic and molecular cytogenetic data not considered by Genome Reference Consortium and thus not included in genome browsers like UCSC, Ensembl or NCBI. Mol Cytogenet 2021, 14:20
• Liehr T. Noninvasive prenatal testing (NIPT), what patients do not learn, may be due to lack of specialist genetic training by gynecologists and obstetricians? Front Genet 2021, 12: 682980.
• Liehr T. International System for Human Cytogenetic or Cytogenomic Nomenclature (ISCN) – some thoughts. Cytogenet Genome Res 2021, 161:223-224.
• Liehr T. Molecular cytogenetics in the era of chromosomics and cytogenomic approaches. Front Genet 2021, 12: 720507.
• Liehr T, Fleischer N, Al-Rikabi A. Next- generation phenotyping in cat- eye syndrome based on computer- aided facial dysmorphology analysis of normal photographs. Mol Genet Genomic Med. 2021; 9:e1785.
• Liehr T, Williams HE, Ziegler M, Kankel S, Padutsch N, Al-Rikabi A. Small supernumerary marker chromosomes derived from chromosome 14 and/or 22. Mol Cytogenet 2021, 14:13.
• Lutz-Bonengel S, Niederstätter H, Naue J, Koziel R, Yang F, Sänger T, Huber G, Berger C, Pflugradt R, Strobl C, Xavier C, Volleth M, Weiß SC, Irwin JA, Romsos EL, Vallone PM, Ratzinger G, Schmuth M, Jansen-Dürr P, Liehr T, Lichter P, Parsons TJ, Pollak S, Parson W. Evidence for multi-copy Mega-NUMTs in the human genome. Nucleic Acids Res 2021, 49:1517-1531.
• Melekhova A, Leeder M, Pungsrinont T, Schmäche T, Kallenbach J, Ehsani M, Mirzakhani K, Rasa SMM, Neri F, Baniahmad A. A novel splice variant of the inhibitor of growth 3 lacks the plant homeodomain and regulates epithelial-mesenchymal transition in prostate cancer cells. Biomolecules 2021, 11: 1152.
• Melekhova A, Baniahmad A. ING tumour suppressors and ING splice variants as coregulators of the androgen receptor signalling in prostate cancer. Cells 2021, 10:2599.
• Miura I, Shams F, Lin S-M, de Bello Cioffi M, Liehr T, Al-Rikabi A, Kuwana C, Srikulnath K, Higaki Y, Ezaz T. Evolution of a multiple sex-chromosome system by three-sided translocations among potential sex-chromosomes in the Taiwanese frog, Odorrana swinhoana. Cells 2021, 10:661.
• Mishra SR, Rawal L, Othman MAK, Thatai A, Sarkar A, Lal V, Bhattacharya SK. Complex rearrangement in acute myeloid leukemia M2 with RUNX1/RUNX1T1 fusion involving chromosomes 8, 17 and 21. Mol Cytogenet 2021;14:28.
• Monteso KCDA, Othman MAK, Capela de Matos RR, Ney Garcia DR, da Rocha MM, de Souza MT, Albagli LF, Liehr T, Land MGP, Silva MLM, Costa ES. An original complex rearrangement involving chromosomes 9, 11, and 14, harboring a complex KMT2A gene rearrangement in an infant with mixed-phenotype acute leukemia. J Pediatr Hematol Oncol 2021, 43:e371-e374.
• Oliveira VCS, Altmanová M, Viana PF, Ezaz T, Bertollo LAC, Ráb P, Liehr T, Al-Rikabi A, Feldberg E, Hatanaka T, Scholz S, Meurer A, Cioffi MdB. Revisiting the karyotypes of alligators and caimans (Crocodylia, Alligatoridae) after a half-century delay: Bridging the gap in chromosomal evolution of reptiles. Cells 2021, 10: 1397.
• Pentzold C, Kokal M, Pentzold S, Weise A. Sites of chromosomal instability in the context of nuclear architecture and function. Cell Mol Life Sci. 2021, 78:2095-2103.
• Piaszinski K, Rincic M, Liehr T, S Azawi. Molecular cytogenetic characterization of the murine melanoma cell lines S91 clone M3 and B16-F1 with variant B16-4A5. Cytogenet Genome Res 2021, 161: 82-92.
• Pungsrinont T, Kallenbach J, Baniahmad A. Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer. Int J Mol Sci 2021, 22:11088.
• Refisch A, Chung HY, Komatsuzaki S, Schumann A, Mühleisen TW, Nöthen MM, Hübner CA, Bär KJ. A common variation in HCN1 is associated with heart rate variability in schizophrenia. Schizophr Res 2021, 229: 73-79.
• Reggio A, Buonomo V, Berkane R, Bhaskara RM, Tellechea M, Peluso I, Polishchuk E, Di Lorenzo G, Cirillo C, Esposito M, Hussain A, Huebner AK, Hübner CA, Settembre C, Hummer G, Grumati P, Stolz A. Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and collagen quality control. EMBO Rep 2021, 22: e52289.
• Rincic M, Rados M, Kopic J, Krsnik Z, Liehr T. 7p21.3 together with a 12p13.32 deletion in a patient with microcephaly - does 12p13.32 locus possible comprises a candidate gene region for microcephaly? Front Mol Neuroscience 2021; 14: 613091.
• Roco ÁS , Liehr T, Ruiz-García A, Guzmán K, Bullejos M. Comparative distribution of repetitive sequences in the karyotypes of Xenopus tropicalis and Xenopus laevis (Anura, Pipidae). Genes 2021, 12:617.
• Rodríguez ME, Cross I, Arias-Pérez A, Portela-Bens S, Merlo MA, Liehr T, Rebordinos L. Cytogenomics unveil the transposable elements driving rearrangements in chromosomes 2 and 4 of Solea senegalensis. Int J Mol Sci 2021, 22:1614.
• Santiago F, Tavares Silvestre R, Barros Otero U, Medeiros Tabalipa M, de Moura Ribeiro-Carvalho M, Rios Scherrer L, Al-Rikabi ABH, Liehr T, Alves G, Ornellas MH. The association of three DNA repair genes polymorphisms on the frequency of chromosomal alterations detected by fluorescence in situ hybridization. Int Arch Occup Environ Health 2021, 94:1567-1577.
• Sassi F, Perez M, Oliveira V, Deon GA, Souza F, Ferreira P, Oliveira, Hatanaka T, Liehr T, Bertollo LAC, de Bello Cioffi M. High genetic diversity despite conserved karyotype organization in the giant trahiras from genus Hoplias (Characiformes, Erythrinidae). Genes 2021; 12:252.
• Sassi F de MC, Moreira-Filho O, Deon GA, Sember A, Bertollo LAC, Liehr T, Oliveira VCS, Viana PF, Feldberg E, Vicari MR, Cioffi M de B. Adding new pieces to the puzzle of karyotype evolution in Harttia (Siluriformes, Loricariidae): Investigation of Amazonian species. Biology 2021, 10:922.
• Schneider F, Duong TA, Metz I, Winkelmeier J, Hübner CA, Endesfelder U, Rust MB. Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function. Prog Neurobiol. 2021; 202:102050.
• Siegmund A, Afzal MA, Tetzlaff F, Keinhörster D, Gratani F, Paprotka K, Westermann M, Nietzsche S, Wolz C, Fraunholz M, Hübner CA, Löffler B, Tuchscherr L. Intracellular persistence of Staphylococcus aureus in endothelial cells is promoted by the absence of phenol-soluble modulins. Virulence 2021, 12:1186-1198.
• Spahiu L, Behluli E, Hadziselimovic R, Liehr T, Temaj G. Mucopolysaccharidosis III: Molecular basis and treatment. Pediatr Endocrinol Diab Metabol 2021, 27: 201-208.
• Spangenberg V, Arakelyan M, Galoyan E, Martirosyan I, Bogomazova A, Martynova E, de Bello Cioffi M, Liehr T, Al-Rikabi A, Osipov F, Petrosyan V, Kolomiets O. Meiotic synapsis of homeologous chromosomes and mismatch repair protein detection in the parthenogenetic rock lizard Darevskia unisexualis. Mol Reprod Dev 2021, 88:119-127.
• Taheri M, Khoshbakht T, Jamali E, Kallenbach J, Ghafouri-Fard S, Baniahmad A. Interaction between non-coding RNAs and androgen receptor with an especial focus on prostate cancer. Cells 2021, 10:3198.
• Taheri M, Najafi S, Basiri A, Hussen BM, Baniahmad A, Jamali E, Ghafouri-Fard S. The Role and Clinical Potentials of Circular RNAs in Prostate Cancer. Front Oncol 2021, 11:781414.
• Trifonov VA, Cioffi MdB, Liehr T. Preface. Cytogenet Genome Res 2021;161:5.
• Tsan S, Kankel S, Padutsch N, Person L, Ziegler M, Al-Rikabi A, Weise A, Mrasek K, Liehr T. About cryptic acrocentric pericentromeric abnormalities in infertile. OBM Genetics 2021, 5:11.
• van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra HJ, Bakker OB, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker AM, Gawor K, Westeneng HJ, Tazelaar GHP, van Eijk KR, Kooyman M, Byrne RP, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith BN, Gromicho M, Chandran S, Pal S, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Sendtner M, Meyer T, Başak N, van der Kooi AJ, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D'Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chiò A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh RH, Bell S, Vourc'h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora Pardina JS, Assialioui A, Rojas-García R, Dion PA, Ross JP, Ludolph AC, Weishaupt JH, Brenner D, Freischmidt A, Bensimon G, Brice A, Durr A, Payan CAM, Saker-Delye S, Wood NW, Topp S, Rademakers R, Tittmann L, Lieb W, Franke A, Ripke S, Braun A, Kraft J, Whiteman DC, Olsen CM, Uitterlinden AG, Hofman A, Rietschel M, Cichon S, Nöthen MM, Amouyel P; SLALOM Consortium; PARALS Consortium; SLAGEN Consortium; SLAP Consortium, Traynor BJ, Singleton AB, Mitne Neto M, Cauchi RJ, Ophoff RA, Wiedau-Pazos M, Lomen-Hoerth C, van Deerlin VM, Grosskreutz J, Roediger A, Gaur N, Jörk A, Barthel T, Theele E, Ilse B, Stubendorff B, Witte OW, Steinbach R, Hübner CA, Graff C, Brylev L, Fominykh V, Demeshonok V, Ataulina A, Rogelj B, Koritnik B, Zidar J, Ravnik-Glavač M, Glavač D, Stević Z, Drory V, Povedano M, Blair IP, Kiernan MC, Benyamin B, Henderson RD, Furlong S, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson GA, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Mather KA, Sachdev PS, Henders AK, Wallace L, de Carvalho M, Pinto S, Petri S, Weber M, Rouleau GA, Silani V, Curtis CJ, Breen G, Glass JD, Brown RH Jr, Landers JE, Shaw CE, Andersen PM, Groen EJN, van Es MA, Pasterkamp RJ, Fan D, Garton FC, McRae AF, Davey Smith G, Gaunt TR, Eberle MA, Mill J, McLaughlin RL, Hardiman O, Kenna KP, Wray NR, Tsai E, Runz H, Franke L, Al-Chalabi A, Van Damme P, van den Berg LH, Veldink JH. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet 2021, 53: 1636-1648.
• Volleth M, Khan FAA, Müller S, Baker RJ, Arenas-Viveros D, Stevens RD, Trifonov V, Liehr T, Heller K-G, Sotero-Caio CG. Cytogenetic investigations in Bornean Rhinolophoidea revealed cryptic diversity in Rhinolophus sedulus entailing classification of Peninsular Malaysia specimens as a new species. Acta Chiropterol 2021, 23: 1-20.
• Volleth M, Müller S, Heller K-G, V Trifonov, Liehr T, Yong H-S, Baker RJ, Aanwarali Khan FA, Sotero-Caio CG. Cytogenetic analyses detect cryptic diversity in Megaderma spasma from Malaysia. Acta Chiropterologica 2021, 23: 271-284.
• Weber M, Weise A, Vasheghani F, Göhner C, Fitzgerald JS, Liehr T, Markert UR. Cytogenomics of six human trophoblastic cell lines. Placenta 2021, 103:72-75.
• Yano CF, Sember A, Kretschmer R, Bertollo LAC, Ezaz T, Hatanaka T, Liehr T, Ráb P, Al-Rikabi A, Ferreira Viana P, Feldberg E, de Oliveira EA, Toma GA, Cioffi MdB. Against the mainstream: exceptional evolutionary stability of l ZW sex chromosomes across fish families Triportheidae and Gasteropelecidae (Teleostei: Characiformes). Chromosome Res 2021, 29:391-416.
• Yeesin P, Buasriyot P, Ditcharoen S, Chaiyasan P, Suwannapoom C, Juntaree S, Jantarat S, Talumphai S, Cioffi MdB, Liehr T, Tanomtong A, Supiwong W. Comparative study of four Mystus species (Bagridae, Siluriformes) from Thailand: insights into their karyotypic diversity. Comp Cytogenet 2021, 15: 119-136.

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