Publikationen

2022

Persistent T-Cell Reactivity in a Seronegative Patient after SARS-CoV-2 Infection and One Vaccination

Nico Andreas, Sebastian Weis, Steffi Kolanos, Sabine Baumgart, Thomas Kamradt, Mathias W Pletz. Vaccines (Basel) 2022 Jan 13;10(1):114. doi: 10.3390/vaccines10010114.

2021

High prevalence of long-term olfactory dysfunction confirmed by olfactory testing after a community COVID-19 outbreak.

Gudziol H, Kirschstein T, Pletz MW, Weis S, Guntinas-Lichius O, Bitter T; CoNAN study group. HNO. 2021 Dec 23:1-8. doi: 10.1007/s00106-021-01129-7. Online ahead of print.

Complicated Long Term Vaccine Induced Thrombotic Immune Thrombocytopenia-A Case Report.

Günther A, Brämer D, Pletz MW, Kamradt T, Baumgart S, Mayer TE, Baier M, Autsch A, Mawrin C, Schönborn L, Greinacher A, Thiele T. Vaccines (Basel). 2021 Nov 17;9(11):1344. doi: 10.3390/vaccines9111344.

Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells.

Beyer M, Henninger SJ, Haehnel PS, Mustafa AM, Gurdal E, Schubert B, Christmann M, Sellmer A, Mahboobi S, Drube S, Sippl W, Kindler T, Krämer OH. Cell Chem Biol. 2021 Nov 9:S2451-9456(21)00475-X. doi: 10.1016/j.chembiol.2021.10.011. Online ahead of print.

Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging.

Andreas N, Müller S, Templin N, Jordan PM, Schuhwerk H, Müller M, Gerstmeier J, Miek L, Andreas S, Werz O, Kamradt T. Arthritis Res Ther. 2021 Aug 24;23(1):222. doi: 10.1186/s13075-021-02596-7.

T cell response after SARS-CoV-2 vaccination in immunocompromised patients with inflammatory bowel disease.

Reuken PA, Andreas N, Grunert PC, Glöckner S, Kamradt T, Stallmach A. J Crohns Colitis. 2021 Aug 11:jjab147. doi: 10.1093/ecco-jcc/jjab147. Online ahead of print.

ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids.

Jordan PM, Andreas N, Groth M, Wegner P, Weber F, Jäger U, Küchler C, Werz O, Serfling E, Kamradt T, Dudeck A, Drube S. Immunology. 2021 Nov;164(3):541-554. doi: 10.1111/imm.13386. Epub 2021 Jun 30.

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.

Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, Kremerskothen J, Kiener HP, Müller S, Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A. Nat Commun. 2021 Jun 15;12(1):3624. doi: 10.1038/s41467-021-23706-8.

Tim-3 is dispensable for allergic inflammation and respiratory tolerance in experimental asthma.

Boehne C, Behrendt AK, Meyer-Bahlburg A, Boettcher M, Drube S, Kamradt T, Hansen G. PLoS One. 2021 Apr 6;16(4):e0249605. doi: 10.1371/journal.pone.0249605. eCollection 2021.

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells.

Pekmezovic M, Hovhannisyan H, Gresnigt MS, Iracane E, Oliveira-Pacheco J, Siscar-Lewin S, Seemann E, Qualmann B, Kalkreuter T, Müller S, Kamradt T, Mogavero S, Brunke S, Butler G, Gabaldón T, Hube B. Nat Microbiol. 2021 May;6(5):643-657. doi: 10.1038/s41564-021-00875-2. Epub 2021 Mar 22.

Severe clinical relapse in an immunocompromised host with persistent SARS-CoV-2 infection.

Reuken PA, Stallmach A, Pletz MW, Brandt C, Andreas N, Hahnfeld S, Löffler B, Baumgart S, Kamradt T, Bauer M. Leukemia. 2021 Mar;35(3):920-923. doi: 10.1038/s41375-021-01175-8. Epub 2021 Feb 19.

Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico.

Weber F, Casalini T, Valentino G, Brülisauer L, Andreas N, Koeberle A, Kamradt T, Contini A, Luciani P. J Mater Chem B. 2021 Mar 4;9(8):2092-2106. doi: 10.1039/d0tb02372h.

Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes.

Eitner A, Müller S, König C, Wilharm A, Raab R, Hofmann GO, Kamradt T, Schaible HG. Int J Mol Sci. 2021 Mar 1;22(5):2477. doi: 10.3390/ijms22052477.

IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction.

Drube S, Müller S, Weber F, Wegner P, Böttcher-Loschinski R, Gaestel M, Hutloff A, Kamradt T, Andreas N. Immunology. 2021 May;163(1):86-97. doi: 10.1111/imm.13305. Epub 2021 Jan 27.

Antibody response using six different serological assays in a completely PCR-tested community after a coronavirus disease 2019 outbreak-the CoNAN study.

Weis S, Scherag A, Baier M, Kiehntopf M, Kamradt T, Kolanos S, Ankert J, Glöckner S, Makarewicz O, Hagel S, Bahrs C, Kimmig A, Proquitté H, Guerra J, Rimek D, Löffler B, Pletz MW; CoNAN Study Group. Clin Microbiol Infect. 2021 Mar;27(3):470.e1-470.e9. doi: 10.1016/j.cmi.2020.11.009. Epub 2020 Nov 20.

2020

Hoppe, A., K. Katsoulis-Dimitriou, H.J. Edler, J. Dudeck, S. Drube, and A. Dudeck. 2020.

Mast cells initiate the vascular response to contact allergens by sensing cell stress.

The Journal of allergy and clinical immunology

Helbig, C., F. Weber, N. Andreas, T. Herdegen, M. Gaestel, T. Kamradt, and S. Drube. 2020.

The IL-33-induced p38-/JNK1/2-TNFalpha axis is antagonized by activation of beta-adrenergic-receptors in dendritic cells.

Scientific reports 10:8152.

Osier, F., J. P. Y. Ting, J. Fraser, B. N. Lambrecht, M. Romano, R. T. Gazzinelli, K. R. Bortoluci, D. S. Zamboni, A. N. Akbar, J. Evans, D. E. Brown, K. D. Patel, Y. Wu, A. B. Perez, O. Pérez, T. Kamradt, C. Falk, M. Barda-Saad, A. Ariel , A. Santoni, F. Annunziato, M. A. Cassatella, H. Kiyono , V. Chereshnev, A. Dieye, M. Mbow, B. Mbengue, M. D. S. Niang and M. Suchard

The global response to the COVID-19 pandemic: how have immunology societies contributed?

Nature Reviews. Immunology 2020 Oct;20(10):594-602.

2019

Brint, E., T. Kamradt, and S.L. Doyle. 2019.

Editorial: IL-1 Family Members in Health and Disease.

Frontiers in immunology

Foertsch, F., T. Kache, S. Drube, C. Biskup, H.P. Nasheuer, and C. Melle. 2019.

Determination of the number of RAD51 molecules in different human cell lines.

Cell Cycle

Cossarizza, A., H.D. Chang, A. Radbruch, A., ..... T. Kamradt, .... and A. Zychlinsky. 2019.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

European journal of immunology

Andreas, N., F. Weber, I. Meininger, N. Templin, M. Gaestel, T. Kamradt, and S. Drube. 2019.

IL-33-activated murine mast cells control the dichotomy between RORgammat(+) and Helios(+) Tregs via the MK2/3-mediated IL-6 production in vitro.

European journal of immunology

de Vries, T.J., I. El Bakkali, T. Kamradt, G. Schett, I.D.C. Jansen, and P. D'Amelio. 2019.

What Are the Peripheral Blood Determinants for Increased Osteoclast Formation in the Various Inflammatory Diseases Associated With Bone Loss?

Frontiers in immunology10:505.

Ebbinghaus, M., S. Muller, G. Segond von Banchet, A. Eitner, I. Wank, A. Hess, I. Hilger, T. Kamradt, and H.G. Schaible. 2019.

The contribution of inflammation and bone destruction to pain in arthritis - a study in murine glucose-6-phosphate isomerase (G6PI)-induced arthritis.

Arthritis & rheumatology

Rao, Z., S. Pace, P.M. Jordan, R. Bilancia, F. Troisi, F. Borner, N. Andreas, T. Kamradt, D. Menche, A. Rossi, C.N. Serhan, J. Gerstmeier, and O. Werz. 2019.

Vacuolar (H(+))-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.

Journal of immunology203:1031-1043.

Ammer-Herrmenau, C., U. Kulkarni, N. Andreas, M. Ungelenk, S. Ravens, C. Hubner, A. Kather, I. Kurth, M. Bauer, and T. Kamradt.

Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations.

PloS one14:e0211716.

Grüneboom, A., Hawwari, I., Weidner, D., Culemann, S., Müller, S., Henneberg, S., Brenzel, A., Merz, S., Bornemann, L., Zec, K., Wuelling, M., Kling, L., Hasenberg, M., Voortmann, S., Lang, S., Baum, W., Ohs, A., Kraff, O., Quick, H., Jäger, M., Landgraeber, S., Dudda, M., Danuser, R., Stein, J., Rohde, M., Gelse, K., Garbe, A., Adamczyk, A., Westendorf, A., Hoffmann, D., Christiansen, S., Engel, D., Vortkamp, A., Krönke, G., Herrmann, M., Kamradt, T., Schett, G., Hasenberg, A. and Gunzer, M.

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Nature Metabolism

2018

Drube, J., T. Ernst, M. Pfirrmann, B.V. Albert, S. Drube, D. Reich, A. Kresinsky, K. Halfter, C. Sorio, C. Fabisch, A. Hochhaus, and F.D. Bohmer. 2018.

PTPRG and PTPRC modulate nilotinib response in chronic myeloid leukemia cells.

Oncotarget 9:9442-9455.

Kamradt, T., M. Amling, B. Dankbar, A. Dudeck, M. Gunzer, A. Ignatius, G. Kronke, K. Kubatzky, T. Pap, I. Prinz, G. Schett, T. Schinke, J. Tuckermann, and A. Waisman. 2018.

Mutual influence of immune system and bones.

Zeitschrift fur Rheumatologie 77:8-11.

Omata, Y., M. Frech, T. Primbs, S. Lucas, D. Andreev, C. Scholtysek, K. Sarter, M. Kindermann, N. Yeremenko, D.L. Baeten, N. Andreas, T. Kamradt, A. Bozec, A. Ramming, G. Kronke, S. Wirtz, G. Schett, and M.M. Zaiss. 2018.

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.

Cell reports 24:169-180.

Schaible, H.G., H.D. Chang, S. Grassel, H. Haibel, A. Hess, T. Kamradt, A. Radbruch, G. Schett, C. Stein, and R.H. Straub. 2018.

Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases.

Zeitschrift fur Rheumatologie 77:24-30.

Andreas N, Riemann M, Castro CN, Groth M, Koliesnik I, Engelmann C, Sparwasser T, Kamradt T, Haenold R, Weih F. 2018

A new RelB-dependent CD117+ CD172a+ murine dendritic cell subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.

European journal of immunology 48:923-936.

Kulkarni, U., C. Herrmenau, S.J. Win, M. Bauer, and T. Kamradt. 2018.

IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.

PloS one 13:e0192304.

Göpfert, C., N. Andreas, F. Weber, N. Hafner, T. Yakovleva, M. Gaestel, T. Kamradt, and S. Drube. 2018.

The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells.

Journal of immunology 200:1198-1206.

2017

Minutti, C.M., S. Drube, N. Blair, C. Schwartz, J.C. McCrae, A.N. McKenzie, T. Kamradt, M. Mokry, P.J. Coffer, M. Sibilia, A.J. Sijts, P.G. Fallon, R.M. Maizels, and D.M. Zaiss. 2017.

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

Immunity 47:710-722 e716.

Drube, S., R. Grimlowski, C. Deppermann, J. Frobel, F. Kraft, N. Andreas, D. Stegner, J. Dudeck, F. Weber, M. Rodiger, C. Gopfert, J. Drube, D. Reich, B. Nieswandt, A. Dudeck, and T. Kamradt. 2017.

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.

Journal of immunology 199:2948-2957.

Ebbinghaus, M., G. Natura, G. Segond von Banchet, S. Hensellek, M. Bottcher, B. Hoffmann, F.S. Salah, M. Gajda, T. Kamradt, and H.G. Schaible. 2017.

Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis.

Scientific reports 7:10334.

Hoffmann, B., C.M. Svensson, M. Strassburger, B. Gebser, I.M. Irmler, T. Kamradt, H. Peter Saluz, and M. Thilo Figge. 2017.

Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging.

Scientific reports 7:2217.

Pletz, M.W., T. Kamradt, and T. Welte. 2017.

Time to follow up when comparing studies of pneumococcal vaccines.

The Lancet. Infectious diseases 17:244-246.

Svensson, C.M., B. Hoffmann, I.M. Irmler, M. Strassburger, M.T. Figge, and H.P. Saluz. 2017.

Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.

Scientific reports 7:44434.

Leist, M., C.A. Sunder, S. Drube, C. Zimmermann, A. Geldmacher, M. Metz, A. Dudeck, and M. Maurer. 2017.

Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation.

Experimental dermatology 26:255-262.

2016

Pletz, M.W., T. Kamradt, C. Forstner, and T. Welte. 2016.

Were Antibody Titers the Right Parameter When Immunologically Comparing Pneumococcal Vaccines?

American journal of respiratory and critical care medicine 194:1447-1448.

Drube, S., F. Kraft, J. Dudeck, A.L. Muller, F. Weber, C. Gopfert, I. Meininger, M. Beyer, I. Irmler, N. Hafner, D. Schutz, R. Stumm, T. Yakovleva, M. Gaestel, A. Dudeck, and T. Kamradt. 2016.

MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation.

Journal of immunology 197:3662-3668.

Freitag, J., L. Berod, T. Kamradt, and T. Sparwasser. 2016.

Immunometabolism and autoimmunity.

Immunology and cell biology 94:925-934.

Wehmeyer, C., S. Frank, D. Beckmann, M. Bottcher, C. Cromme, U. Konig, M. Fennen, A. Held, P. Paruzel, C. Hartmann, A. Stratis, A. Korb-Pap, T. Kamradt, I. Kramer, W. van den Berg, M. Kneissel, T. Pap, and B. Dankbar. 2016.

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.

Science translational medicine 8:330ra335.

Win, S.J., A.A. Kuhl, T. Sparwasser, T. Hunig, and T. Kamradt. 2016.

In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.

European journal of immunology 46:1193-1202.

Kulkarni, U., C.M. Karsten, T. Kohler, S. Hammerschmidt, K. Bommert, B. Tiburzy, L. Meng, L. Thieme, A. Recke, R.J. Ludwig, K. Pollok, K. Kalies, B. Bogen, M. Boettcher, T. Kamradt, A.E. Hauser, C. Langer, M. Huber-Lang, F.D. Finkelman, J. Kohl, D.M. Wong, and R.A. Manz. 2016.

IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration.

The Journal of allergy and clinical immunology 137:1487-1497 e1486.

2015

Llop-Guevara, A., M. Porras, C. Cendon, I. Di Ceglie, F. Siracusa, F. Madarena, V. Rinotas, L. Gomez, P.L. van Lent, E. Douni, H.D. Chang, T. Kamradt, and J. Roman. 2015.

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.

Arthritis research & therapy 17:356.

Drube, S., F. Weber, C. Gopfert, R. Loschinski, M. Rothe, F. Boelke, M.A. Diamanti, T. Lohn, J. Ruth, D. Schutz, N. Hafner, F.R. Greten, R. Stumm, K. Hartmann, O.H. Kramer, A. Dudeck, and T. Kamradt. 2015.

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

Oncotarget 6:28833-28850.

Hünemörder, S., J. Treder, S. Ahrens, V. Schumacher, H.J. Paust, T. Menter, P. Matthys, T. Kamradt, C. Meyer-Schwesinger, U. Panzer, H. Hopfer, and H.W. Mittrucker. 2015.

TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis.

The Journal of pathology 237:62-71.

Drube, S., F. Weber, R. Loschinski, M. Beyer, M. Rothe, A. Rabenhorst, C. Gopfert, I. Meininger, M.A. Diamanti, D. Stegner, N. Hafner, M. Bottcher, K. Reinecke, T. Herdegen, F.R. Greten, B. Nieswandt, K. Hartmann, O.H. Kramer, and T. Kamradt. 2015.

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

Oncotarget 6:5354-5368.

Humrich, J.Y., T. Kamradt, and G. Riemekasten. 2015.

Regulatory T cells and rheumatic diseases.

Zeitschrift fur Rheumatologie 74:26-32.

Hennig, D., S. Muller, C. Wichmann, S. Drube, K. Pietschmann, L. Pelzl, M. Grez, G. Bug, T. Heinzel, and O.H. Kramer. 2015.

Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells.

British journal of cancer 112:329-337.

2014

Freitag, J., S. Heink, E. Roth, J. Wittmann, H.M. Jack, and T. Kamradt. 2014.

Towards the generation of B-cell receptor retrogenic mice.

PloS one 9:e109199.

Irmler, I.M., P. Gebhardt, B. Hoffmann, T. Opfermann, M.T. Figge, H.P. Saluz, and T. Kamradt. 2014.

18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis.

Arthritis research & therapy 16:R155.

Irmler, I.M., M. Gajda, and T. Kamradt. 2014.

Amelioration of experimental arthritis by stroke-induced immunosuppression is independent of Treg cell function.

Annals of the rheumatic diseases 73:2183-2191.

2013

Berrocal Almanza, L.C., M. Munoz, A.A. Kuhl, T. Kamradt, M.M. Heimesaat, and O. Liesenfeld. 2013.

Tim-3 is differently expressed in genetically susceptible C57BL/6 and resistant BALB/c mice during oral infection with Toxoplasma gondii.

European journal of microbiology & immunology 3:211-221.

Kamradt, T., and S. Drube. 2013.

A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis.

Arthritis research & therapy 15:115.

Müller, U., W. Stenzel, D. Piehler, A. Grahnert, M. Protschka, G. Kohler, O. Frey, J. Held, T. Richter, M. Eschke, T. Kamradt, F. Brombacher, and G. Alber. 2013.

Abrogation of IL-4 receptor-alpha-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response.

International immunology 25:459-470.

Huber, M., S. Heink, A. Pagenstecher, K. Reinhard, J. Ritter, A. Visekruna, A. Guralnik, N. Bollig, K. Jeltsch, C. Heinemann, E. Wittmann, T. Buch, O. Prazeres da Costa, A. Brustle, D. Brenner, T.W. Mak, H.W. Mittrucker, B. Tackenberg, T. Kamradt, and M. Lohoff. 2013.

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.

The Journal of clinical investigation 123:247-260.

2012

Kamradt, T., A. Radbruch, and H.D. Chang. 2012.

Bad memories: understanding and removal of pathogenic consequences of immunological memory in inflammatory rheumatic diseases. The IMPAM consortium.

Zeitschrift fur Rheumatologie 71:501-503.

Dörner, T., K. Hartung, G.R. Burmester, E. Genth, T. Kamradt, R. Mierau, C. Specker, and U. von Hinuber. 2012.

Recommendations of the Laboratory Commission of the German Society of Rheumatology (DGRh) on further training of rheumatologists in the field of rheumatological and immunological laboratory diagnostics.

Zeitschrift fur Rheumatologie 71:328-329.

Simon, S., R. Guthke, T. Kamradt, and O. Frey. 2012.

Multivariate analysis of flow cytometric data using decision trees.

Frontiers in microbiology 3:114.

Weber, M., S. Lambeck, N. Ding, S. Henken, M. Kohl, H.P. Deigner, D.P. Enot, E.I. Igwe, L. Frappart, M. Kiehntopf, R.A. Claus, T. Kamradt, D. Weih, Y. Vodovotz, D.E. Briles, A.D. Ogunniyi, J.C. Paton, U.A. Maus, and M. Bauer. 2012.

Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26:2424-2436.

Schett, G., T. Pap, U. Muller-Ladner, and T. Kamradt. 2012.

Osteoimmunology - IMMUNOBONE - Understanding the interaction between bone and immune system.

Zeitschrift fur Rheumatologie 71:138-139.

Müller, U., D. Piehler, W. Stenzel, G. Kohler, O. Frey, J. Held, A. Grahnert, T. Richter, M. Eschke, T. Kamradt, F. Brombacher, and G. Alber. 2012.

Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal immunology 5:299-310.

Drube, S., F. Schmitz, C. Gopfert, F. Weber, and T. Kamradt. 2012.

C-Kit controls IL-1beta-induced effector functions in HMC-cells.

European journal of pharmacology 675:57-62.

2011

Chang, H.D., T. Kamradt, and H. Schulze-Koops. 2011.

Th1, Th17 and Th1+17 cells.

Zeitschrift fur Rheumatologie 70:862-865.

Baschant, U., L. Frappart, U. Rauchhaus, L. Bruns, H.M. Reichardt, T. Kamradt, R. Brauer, and J.P. Tuckermann. 2011.

Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.

Proceedings of the National Academy of Sciences of the United States of America 108:19317-19322.

Chang, H.D., and T. Kamradt. 2011.

Intestinal microbiota as regulator of the immune system.

Zeitschrift fur Rheumatologie 70:790-792.

Frey, O., L. Bruns, L. Morawietz, K. Dunussi-Joannopoulos, and T. Kamradt. 2011.

B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis.

PloS one 6:e24718.

Kamradt, T., and K. Ferrari-Kuhne. 2011.

Adaptive immunity.

Deutsche medizinische Wochenschrift 136:1678-1683.

Kamradt, T., and H.D. Chang. 2011.

Diversity and flexibility of Th17 effector functions.

Arthritis research & therapy 13:106.

Zaiss, M.M., M. Kurowska-Stolarska, C. Bohm, R. Gary, C. Scholtysek, B. Stolarski, J. Reilly, S. Kerr, N.L. Millar, T. Kamradt, I.B. McInnes, P.G. Fallon, J.P. David, F.Y. Liew, and G. Schett. 2011.

IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss.

Journal of immunology 186:6097-6105.

Ohno, T., K. Oboki, H. Morita, N. Kajiwara, K. Arae, S. Tanaka, M. Ikeda, M. Iikura, T. Akiyama, J. Inoue, K. Matsumoto, K. Sudo, M. Azuma, K. Okumura, T. Kamradt, H. Saito, and S. Nakae. 2011.

Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.

PloS one 6:e18404.

Walther, M., P. Gebhardt, P. Grosse-Gehling, L. Wurbach, I. Irmler, S. Preusche, M. Khalid, T. Opfermann, T. Kamradt, J. Steinbach, and H.P. Saluz. 2011.

Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 69:852-857.

Berod, L., C. Heinemann, S. Heink, A. Escher, C. Stadelmann, S. Drube, R. Wetzker, J. Norgauer, and T. Kamradt. 2011.

PI3Kgamma deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome.

European journal of immunology 41:833-844.

Frey, O., T. Mitera, H. Kelchtermans, E. Schurgers, T. Kamradt, and P. Matthys. 2011.

Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-gamma receptor knockout mice exposes an arthritis-promoting role of IFN-gamma.

Journal of autoimmunity 36:161-169.

Frey, O., and T. Kamradt. 2011.

Biologics. Magic bullets - magic effects - magic costs? New therapeutics and their effects.

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 108:7-12.

Gerbaulet, A., C. Wickenhauser, J. Scholten, K. Peschke, S. Drube, H.P. Horny, T. Kamradt, R. Naumann, W. Muller, T. Krieg, C. Waskow, K. Hartmann, and A. Roers. 2011.

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.

Blood 117:2012-2021.

2010

Lexberg, M.H., A. Taubner, I. Albrecht, I. Lepenies, A. Richter, T. Kamradt, A. Radbruch, and H.D. Chang. 2010.

IFN-gamma and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells.

European journal of immunology 40:3017-3027.

Irmler, I.M., T. Opfermann, P. Gebhardt, M. Gajda, R. Brauer, H.P. Saluz, and T. Kamradt. 2010.

In vivo molecular imaging of experimental joint inflammation by combined (18)F-FDG positron emission tomography and computed tomography.

Arthritis research & therapy 12:R203.

Truta-Feles, K., M. Lagadari, K. Lehmann, L. Berod, S. Cubillos, S. Piehler, Y. Herouy, D. Barz, T. Kamradt, A. Maghazachi, and J. Norgauer. 2010.

Histamine modulates gammadelta-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways.

British journal of pharmacology 161:1291-1300.

Kamradt, T., and O. Frey. 2010.

Arthritis: where are the T cells?

Arthritis research & therapy 12:122.

Frey, O., J. Meisel, A. Hutloff, K. Bonhagen, L. Bruns, R.A. Kroczek, L. Morawietz, and T. Kamradt. 2010.

Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis.

Annals of the rheumatic diseases 69:1495-1501.

Frey, O., A. Reichel, K. Bonhagen, L. Morawietz, U. Rauchhaus, and T. Kamradt. 2010.

Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis.

Annals of the rheumatic diseases 69:1511-1518.

Drube, S., S. Heink, S. Walter, T. Lohn, M. Grusser, A. Gerbaulet, L. Berod, J. Schons, A. Dudeck, J. Freitag, S. Grotha, D. Reich, O. Rudeschko, J. Norgauer, K. Hartmann, A. Roers, and T. Kamradt. 2010.

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.

Blood 115:3899-3906.

2009

Munoz, M., M.M. Heimesaat, K. Danker, D. Struck, U. Lohmann, R. Plickert, S. Bereswill, A. Fischer, I.R. Dunay, K. Wolk, C. Loddenkemper, H.W. Krell, C. Libert, L.R. Lund, O. Frey, C. Holscher, Y. Iwakura, N. Ghilardi, W. Ouyang, T. Kamradt, R. Sabat, and O. Liesenfeld. 2009.

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

The Journal of experimental medicine 206:3047-3059.

Frey, O., and T. Kamradt. 2009.

Effector function plasticity of T helper lymphocytes.

Zeitschrift fur Rheumatologie 68:834-835.

Bruns, L., O. Frey, L. Morawietz, C. Landgraf, R. Volkmer, and T. Kamradt. 2009. Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice.

Arthritis research & therapy 11:R117.

Hagenow, K., K.A. Gelderman, M. Hultqvist, P. Merky, J. Backlund, O. Frey, T. Kamradt, and R. Holmdahl. 2009.

Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice.

Journal of immunology 183:874-881.

Huber, M., S. Heink, H. Grothe, A. Guralnik, K. Reinhard, K. Elflein, T. Hunig, H.W. Mittrucker, A. Brustle, T. Kamradt, and M. Lohoff. 2009.

A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity.

European journal of immunology 39:1716-1725.

Lagadari, M., K. Truta-Feles, K. Lehmann, L. Berod, M. Ziemer, M. Idzko, D. Barz, T. Kamradt, A.A. Maghazachi, and J. Norgauer. 2009.

Lysophosphatidic acid inhibits the cytotoxic activity of NK cells: involvement of Gs protein-mediated signaling.

International immunology 21:667-677.

Lagadari, M., K. Lehmann, M. Ziemer, K. Truta-Feles, L. Berod, M. Idzko, D. Barz, T. Kamradt, A.A. Maghazachi, and J. Norgauer. 2009.

Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling.

International journal of oncology 34:287-294.

2008

Lexberg, M.H., A. Taubner, A. Forster, I. Albrecht, A. Richter, T. Kamradt, A. Radbruch, and H.D. Chang. 2008.

Th memory for interleukin-17 expression is stable in vivo.

European journal of immunology 38:2654-2664.

Niesner, U., I. Albrecht, M. Janke, C. Doebis, C. Loddenkemper, M.H. Lexberg, K. Eulenburg, S. Kreher, J. Koeck, R. Baumgrass, K. Bonhagen, T. Kamradt, P. Enghard, J.Y. Humrich, S. Rutz, U. Schulze-Topphoff, O. Aktas, S. Bartfeld, H. Radbruch, A.N. Hegazy, M. Lohning, D.C. Baumgart, R. Duchmann, M. Rudwaleit, T. Haupl, I. Gitelman, V. Krenn, J. Gruen, J. Sieper, M. Zeitz, B. Wiedenmann, F. Zipp, A. Hamann, M. Janitz, A. Scheffold, G.R. Burmester, H.D. Chang, and A. Radbruch. 2008.

Autoregulation of Th1-mediated inflammation by twist1.

The Journal of experimental medicine 205:1889-1901.

Lünemann, J.D., O. Frey, T. Eidner, M. Baier, S. Roberts, J. Sashihara, R. Volkmer, J.I. Cohen, G. Hein, T. Kamradt, and C. Munz. 2008.

Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis.

Journal of immunology 181:991-1000.

2007

Kamradt, T. 2007.

Th17 cells.

Zeitschrift fur Rheumatologie 66:54-55.

Brüstle, A., S. Heink, M. Huber, C. Rosenplanter, C. Stadelmann, P. Yu, E. Arpaia, T.W. Mak, T. Kamradt, and M. Lohoff. 2007.

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.

Nature immunology 8:958-966.

Lünemann, J.D., T. Kamradt, R. Martin, and C. Munz. 2007.

Epstein-barr virus: environmental trigger of multiple sclerosis?

Journal of virology 81:6777-6784.

Lanzke, N., R. Kleinwachter, S. Kerschischnik, L. Sargsyan, D.A. Groneberg, T. Kamradt, O. Liesenfeld, V. Krenn, M. Sander, and C. Spies. 2007.

Differential effects of ethanol on IFN-gamma- and TNF-alpha-producing splenic T lymphocytes in a murine model of gram-negative pneumonia.

Addiction biology 12:59-68.

Kursar, M., M. Koch, H.W. Mittrucker, G. Nouailles, K. Bonhagen, T. Kamradt, and S.H. Kaufmann. 2007.

Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis.

Journal of immunology 178:2661-2665.

Alber, G.K., T. 2007.

Regulation of protective and pathogenic Th17 responses.

Current Immunology Reviews 3:3 - 16.

2006

Durinovic-Bello, I., S. Rosinger, J.A. Olson, M. Congia, R.C. Ahmad, M. Rickert, J. Hampl, H. Kalbacher, J.W. Drijfhout, E.D. Mellins, S. Al Dahouk, T. Kamradt, M.J. Maeurer, C. Nhan, B.O. Roep, B.O. Boehm, C. Polychronakos, G.T. Nepom, W. Karges, H.O. McDevitt, and G. Sonderstrup. 2006.

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.

Proceedings of the National Academy of Sciences of the United States of America 103:11683-11688.

Fischer, T., I. Gemeinhardt, S. Wagner, D.V. Stieglitz, J. Schnorr, K.G. Hermann, B. Ebert, D. Petzelt, R. Macdonald, K. Licha, M. Schirner, V. Krenn, T. Kamradt, and M. Taupitz. 2006.

Assessment of unspecific near-infrared dyes in laser-induced fluorescence imaging of experimental arthritis.

Academic radiology 13:4-13.

Debes, G.F., M.E. Dahl, A.J. Mahiny, K. Bonhagen, D.J. Campbell, K. Siegmund, K.J. Erb, D.B. Lewis, T. Kamradt, and A. Hamann. 2006.

Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus.

Journal of immunology 176:557-566.