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Institut für Pharmakologie und Toxikologie
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Startseite / Forschung / Rezeptorpharmakologie
Rezeptorpharmakologie

Die Arbeitsgruppe untersucht die Lokalisation, Regulation und Funktion von G-Protein-gekoppelten Rezeptoren einschließlich der Opioid- und Somatostatin-Rezeptoren. Im Zentrum der Forschung stehen dabei die Mechanismen der agonist-induzierten Phosphorylierung dieser Rezeptoren sowie die physiologische Relevanz der Phosphorylierung bei der Regulation der Signalübertragung und Toleranzentwiklung.
Kontakt:

Prof. Dr. med. Stefan Schulz

Tel.: 49 3641 93 25650
Fax: 49 3641 93 25652

Mitarbeiter

Lupp, Amelie; apl. Prof. Dr. med.                93 25 678                                  

Kliewer, Andrea;  PD Dr. rer. nat.habil.       93 25 671

Miess-Tanneberg, Elke; Dr. rer. nat             93 25 667

Reinscheid, Rainer; Dr. rer. nat.                  93 25 656

Fritzwanker, Sebastian; Dr. rer. nat.           93 25 661

Blum, Nina Kathleen; Dipl.                         93 25 665    

 

Kruck, Stephanie                                         93 25 661 

Schiemenz, Ulrike                                       93 25 683

Würl, Swetlana                                            93 25 683

Brendel, Monique                                       93 25 665    

Bechmann, Stefan;  Tierhaus                     93 25 705

Drittmittelprojekte

  • DFG: Auswirkungen einer forcierten Desensitisierung von µ-Opioid-Rezeptoren auf analgetische und atemdepressive      Toleranzentwicklung in vivo
  • DFG: Genetische Dissoziation der G-Protein- und Arrestin-gekoppelten Signalübertragung am µ-Opioid-Rezeptor in vivo.
  • DFG: Regulierte Endozytose und postendozytotischer Transport von Somatostatin-Rezeptoren
  • DFG: Regulation der Opioidtoleranz durch agonist-selektive Phosphorylierung endogener µ-Opioid-Rezeptoren in vivo
  • Deutsche Krebshilfe: Somatostatin-Rezeptoren als pharmakologische Zielstrukturen für die Diagnose und Therapie
  • SFB TP C05: Echtzeit-Analyse der Phosphorylierung und Dephosphorylierung des μ-Opioid-Rezeptors

Publikationen

2024

  1. Dietz A, Senf K, Neuhaus EM. Stem cell expressed CXCR4 regulates tissue composition in the vomeronasal organ. J Cell Sci. 2024 Dec 6:jcs.263451. doi: 10.1242/jcs.263451
  2. Walker MF, Zhang J, Steiner W, Ku PI, Zhu JF, Michaelson Z, Yen YC, Lee A, Long AB, Casey MJ, Poddar A, Nelson IB, Arveseth CD, Nagel F, Clough R, LaPotin S, Kwan KM, Schulz S, Stewart RA, Tesmer JJG, Caspary T, Subramanian R, Ge X, Myers BR. GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. PLoS Biol. 22(8):e3002685, 2024
  3. Jaeckel ER, Arias-Hervert ER, Perez-Medina AL, Schulz S, Birdsong WT. Chronic Morphine Treatment Induces Sex- and Synapse-Specific Cellular Tolerance on Thalamo-Cortical Mu Opioid Receptor Signaling. J Neurophysiol. 132(3):968-978, 2024
  4. Underwood O, Fritzwanker S, Glenn J, Blum NK, Batista-Gondin A, Drube J, Hoffmann C, Briddon SJ, Schulz S, Canals M. Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited. Commun Biol. 7(1):933, 2024
  5. Beyer AL, Kaemmerer D, Sänger J, Lupp A. Expression of FAM159B in Humans, Rats, and Mice: A Cross-species Examination. J Histochem Cytochem. 72(7):467-487, 2024
  6. Ruhnke N, Beyer AL, Kaemmerer D, Sänger J, Schulz S, Lupp A. Expression of free fatty acid receptor 2 in normal and neoplastic tissues. Exp Mol Pathol. 137:104902, 2024
  7. Blum NK, Schaffner A, Drube J, Nagel F, Reinscheid RK, Hoffmann C, Schulz S. Rapid elucidation of agonist-driven regulation of the neurokinin 1 receptor using a GPCR phosphorylation immunoassay. Eur J Pharmacol. 973:176587, 2024
  8. Dietz A, Senf K, Neuhaus EM. ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa. Glia. 72(6):1183-1200, 2024
  9. Oteng AB, Pittala S, Kliewer A, Qiu Y, Wess J. Hepatic GRK2 is dispensable for glucose homeostasis and other key metabolic parameters in mice. Mol Metab. 79:101866, 2024
  10. Le VH, Orniacki C, Murcia-Belmonte V, Denti L, Schütz D, Stumm R, Ruhrberg C, Erskine L. CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm. Development 151(2):dev202446, 2024
  11. Jaeckel ER, Herrera YN, Schulz S, Birdsong WT. Chronic morphine induces adaptations in opioid receptor signaling in a thalamo-striatal circuit that are location-dependent, sex-specific and regulated by mu opioid receptor phosphorylation. J Neurosci. 44(3):e0293232023, 2024

2023

  1. Bhat S, Dietz A, Senf K, Nietzsche S, Hirabayashi Y, Westermann M, Neuhaus EM. GPRC5C regulates the composition of cilia in the olfactory system. BMC Biol. 21(1):292, 2023
  2. Leo LM, Al-Zoubi R, Hurst DP, Stephan AP, Zhao P, Tilley DG, Miess E, Schulz S, Abood ME, Reggio PH. The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor. Cannabis Cannabinoid Res. 8(5):731-748, 2023
  3. Kostenis E, Gomeza J, Miess-Tanneberg E, Blum NK, Benkel T, Chevigné A, Hoffmann C, Kolb P, Nikolaev V, Waldhoer M, Szpakowska M, Inoue A, Schulz S. Reply to: How carvedilol does not activate β2-adrenoceptors. Nat Commun. 14(1):7867, 2023
  4. Barki N, Jenkins L, Marsango S, Dedeo D, Bolognini D, Dwomoh L, Abdelmalik AM, Nilsen M, Stoffels M, Nagel F, Schulz S, Tobin AB, Milligan G. Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. Elife. 12:RP91861, 2023
  5. Oron-Herman M, Kirmayer D, Lupp A, Schulz S, Kostenich G, Afargan M. Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach. Sci Rep. 13(1):20857, 2023
  6. Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu JM, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy P, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Woodruff TM, Yao C, Ye RD. The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 2023 Oct;180 Suppl 2:S23-S144. doi: 10.1111/bph.16177
  7. Gerlach L, Beyer AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A. Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues. Sci Rep. 13(1):18993, 2023
  8. Modena D, Moras ML, Sandrone G, Stevenazzi A, Vergani B, Dasgupta P, Kliever A, Gulde S, Marangelo A, Schillmaier M, Luque RM, Bäuerle S, Pellegata NS, Schulz S, Steinkühler C. Identification of a Novel SSTR3 Full Agonist for the Treatment of Nonfunctioning Pituitary Adenomas. Cancers (Basel), 15(13):3453, 2023
  9. Dietz A, Senf K, Karius J, Stumm R, Neuhaus EM. Glia Cells Control Olfactory Neurogenesis by Fine-Tuning CXCL12. Cells 12(17):2164, 2023
  10. Requana Aradas A, Djaboub Y, McCort-Tranchepain I, Hajasova Z, Clémenceau L, Canestrelli C, Mann A, Schulz S, Delaval A, Acher F, Massotte D, Noble F, Marie N. Activation of the mu-delta opioid receptor heteromers blocks morphine rewarding effects. Int J Neuropsychopharmacol. 26(7):513-521, 2023
  11. Celik MÖ, Seitz V, Yergöz F, Dembla S, Blum NK, Schulz S, Stein C. Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP. Front Mol Neurosci. 16:1171855, 2023
  12. Walker MF, Zhang J, Steiner W, Ku PI, Zhu JF, Michaelson Z, Yen YC, Long AB, Casey MJ, Poddar A, Nelson IB, Arveseth CD, Nagel F, Clough R, LaPotin S, Kwan KM, Schulz S, Stewart RA, Tesmer JJG, Caspary T, Subramanian R, Ge X, Myers BR. GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade. bioRxiv. 2023 Jul 1:2023.05.10.540226. doi: 10.1101/2023.05.10.540226
  13. Groom S, Blum NK, Conibear AE, Disney A, Hill R, Husbands SM, Li Y, Toll L, Kliewer A, Schulz S, Henderson G, Kelly E, Bailey CP. A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase. Br J Pharmacol. 180(7):943-957, 2023
  14. Press AT, Ungelenk L, Medyukhina A, Pennington SA, Nietzsche S, Kan C, Lupp A, Dahmen U, Wang R, Settmacher U, Wetzker R, Figge MT, Clemens MG, Bauer M. Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury. Free Radic Biol Med. 204:151-160, 2023
  15. Thompson JM, Tragge W, Flood ED, Schulz S, Lisabeth E, Watts SW. Development of a 5-HT7 receptor antibody for the rat: the good, the bad, and the ugly. Naunyn Schmiedebergs Arch Pharmacol. 396(10):2599-2611, 2023
  16. Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies. Commun Biol. 6(1):419, 2023
  17. Wende B, Beyer AL, Ruhnke N, Kaemmerer D, Sänger J, Schulz S, Lupp A. Expression of the Calcitonin Receptor-like Receptor (CALCRL) in Normal and Neoplastic Tissues. Int J Mol Sci. 24(4):3960, 2023
  18. Wang S, de Fabritus L, Kumar PA, Werner Y, Ma M, Li D, Siret C, Simic M, Li B, Kerdiles YM, Hou L, Stumm R, van de Pavert SA. Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke. J Neuroinflammation. 20(1):8, 2023

2022

  1. Albadry M, Höpfl S, Ehteshamzad N, König M, Böttcher M, Neumann J, Lupp A, Dirsch O, Radde N, Christ B, Christ M, Schwen LO, Laue H, Klopfleisch R, Dahmen U. Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism. Sci Rep. 12(1):21825, 2022
  2. Benkel T, Zimmermann M, Zeiner J, Bravo S, Merten N, Lim VJY, Matthees ESF, Drube J, Miess-Tanneberg E, Malan D, Szpakowska M, Monteleone S, Grimes J, Koszegi Z, Lanoiselée Y, O'Brien S, Pavlaki N, Dobberstein N, Inoue A, Nikolaev V, Calebiro D, Chevigné A, Sasse P, Schulz S, Hoffmann C, Kolb P, Waldhoer M, Simon K, Gomeza J, Kostenis E. How Carvedilol activates β2-adrenoceptors. Nat Commun. 13(1):7109, 2022
  3. Siret C, van Lessen M, Bavais J, Jeong HW, Reddy Samawar SK, Kapupara K, Wang S, Simic M, de Fabritus L, Tchoghandjian A, Fallet M, Huang H, Sarrazin S, Sieweke MH, Stumm R, Sorokin L, Adams RH, Schulte-Merker S, Kiefer F, van de Pavert SA. Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain. Nat Commun. 13(1):7366, 2022
  4. Kaufmann J, Blum NK, Nagel F, Schuler A, Drube J, Degenhart C, Engel J, Eickhoff JE, Dasgupta P, Fritzwanker S, Guastadisegni M, Schulte C, Miess-Tanneberg E, Maric HM, Spetea M, Kliewer A, Baumann M, Klebl B, Reinscheid RK, Hoffmann C, Schulz S. A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening. Commun Biol. 5(1):1206, 2022
  5. Beyer AL, Kaemmerer D, Sänger J, Lupp A. Co-Expression of Adaptor Protein FAM159B with Different Markers for Neuroendocrine Cells: An Immunocytochemical and Immunohistochemical Study. Int J Mol Sci. 23(21):13503, 2022
  6. Petese A, Fries FL, Broske B, Stumm R, Blaess S: Lineage Analysis of Cxcr4-Expressing Cells in the Developing Midbrain Suggests That Progressive Competence Restriction in Dopaminergic Progenitor Cells Contributes to the Establishment of Dopaminergic Neuronal Diversity. eNeuro. 9(4):ENEURO.0052-22.2022, 2022
  7. Rösner E, Kaemmerer D, Sänger J, Lupp A: Evaluation of PD-L1 expression in a large set of gastroenteropancreatic neuroendocrine tumours and correlation with clinicopathological data. Transl Oncol. 25:101526, 2022
  8. Ehms B, Kaemmerer D, Sänger J, Schulz S, Lupp A: Reassessment of somatostatin receptor SST4 expression in bronchopulmonary and gastroenteropancreatic neuroendocrine neoplasms using the novel rabbit monoclonal anti-human SST4 antibody 7H49L61. Sci Rep. 12(1):14722, 2022
  9. Venkataramanappa S, Saaber F, Abe P, Schütz D, Kumar PA, Stumm R: Cxcr4 and Ackr3 regulate allocation of caudal ganglionic eminence-derived interneurons to superficial cortical layers. Cell Rep. 40(5):111157, 2022
  10. Czajkowski M, Kaemmerer D, Sänger J, Sauter G, Wirtz RM, Schulz S, Lupp A: Comparative evaluation of somatostatin and CXCR4 receptor expression in different types of thyroid carcinoma using well-characterised monoclonal antibodies. BMC Cancer 22(1):740, 2022
  11. Leo LM, Al-Zoubi R, Hurst DP, Stephan AP, Zhao P, Tilley DG, Miess E, Schulz S, Abood ME, Reggio PH: The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor. Cannabis Cannabinoid Res. 2022 Jul 6. doi: 10.1089/can.2021.0223.

  12. Garau C, Liu X, Calo G, Schulz S, Reinscheid RK: Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus. Neuroscience 496:83-95, 2022

  13. Bubb M, Beyer ASL, Dasgupta P, Kaemmerer D, Sänger J, Evert K, Wirtz RM, Schulz S, Lupp A: Assessment of G Protein-Coupled Oestrogen Receptor Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody. Int J Mol Sci. 23:519, 2022

  14. Kotzerke J, Buesser D, Naumann A, Runge R, Huebinger L, Kliewer A, Freudenberg R, Brogsitter C. Epigenetic-Like Stimulation of Receptor Expression in SSTR2 Transfected HEK293 Cells as a New Therapeutic Strategy. Cancers (Basel). 14(10):2513, 2022
  15. Dasgupta P, Mann A, Polgar WE, Reinscheid RK, Zaveri NT, Schulz S: Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics. Sci Rep. 12(1):7154, 2022
  16. Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M: ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nat Commun. 13(1):1823, 2022
  17. Marsango S, Ward RJ, Jenkins L, Butcher AJ, Al Mahmud Z, Dwomoh L, Nagel F, Schulz S, Tikhonova IG, Tobin AB, Milligan G: Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. J Biol Chem. 298(5):101932, 2022
  18. Beuker C, Schafflick D, Strecker JK, Heming M, Li X, Wolbert J, Schmidt-Pogoda A, Thomas C, Kuhlmann T, Aranda-Pardos I, A-Gonzalez N, Kumar PA, Werner Y, Kilic E, Hermann DM, Wiendl H, Stumm R, Hörste GMZ, Minnerup J: Stroke induces disease-specific myeloid cells in the brain parenchyma and pia.  Nat Commun. 13(1):945, 2022
  19. Divorty N, Jenkins L, Ganguly A, Butcher AJ, Hudson BD, Schulz S, Tobin AB, Nicklin SA, Milligan G: Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor. J Biol Chem. 298(3):101655, 2022
  20. Drube J, Haider RS, Matthees ESF, Reichel M, Zeiner J, Fritzwanker S, Ziegler C, Barz S, Klement L, Filor J, Weitzel V, Kliewer A, Miess-Tanneberg E, Kostenis E, Schulz S, Hoffmann C: GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation. Nat Commun. 13(1):540, 2022

2021

  1. Lupp A, Ehms B, Stumm R, Göckeritz J, Mawrin C, Schulz S: Reassessment of SST4 somatostatin receptor expression using SST4-eGFP knockin mice and the novel rabbit monoclonal anti-human SST4 antibody 7H49L61. Int J Mol Sci. 22(23):12981, 2021
  2. Beyer ASL, Kaemmerer D, Sänger J, Evert K, Lupp, A: Immunohistochemical evaluation of adaptor protein FAM159B expression in normal and neoplastic human tissues. Int J Mol Sci. 22:1225, 2021
  3. Dasgupta P, Gűnther T, Schulz S: Pharmacological characterization of veldoreotide as a somatostatin receptor 4 agonist. Life (Basel) 11(10):1075, 2021
  4. Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu JM, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy P, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Woodruff TM, Yao C, Ye RD: The concise guide to pharmacology 2021/22: G protein-coupled receptors. Br J Pharmacol. 178 Suppl 1:S27-S156, 2021
  5. Fritzwanker S, Moulédous L, Mollereau C, Froment C, Burlet-Schiltz O, Effah F, Bailey A, Spetea M, Reinscheid RK, Schulz S, Kliewer A: HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants. Commun Biol. 4:1070, 2021
  6. Ridge LA, Kewbank D, Schütz D, Stumm R, Scambler PJ, Ivins S: Dual role for CXCL12 signaling in semilunar valve development. Cell Rep. 36(8):109610, 2021
  7. Fritzwanker S, Schulz S, Kliewer A: SR-17018 stimulates atypical µ-opioid receptor phosphorylation and dephosphorylation. Molecules 26(15):4509, 2021
  8. Gulde S, Wiedemann T, Schillmaier M, Valença I, Lupp A, Steiger K, Yen HY, Bäuerle S, Notni J, Luque R, Schmid H, Schulz S, Ankerst DP, Schilling F, Pellegata NS: Gender-Specific Efficacy Revealed by Head-to-Head Comparison of Pasireotide and Octreotide in a Representative In Vivo Model of Nonfunctioning Pituitary Tumors. Cancers 13(12):3097, 2021
  9. Si W, Liu X, Pape HC, Reinscheid RK: Neuropeptide S-mediated modulation of prepulse inhibition depends on age, gender, stimulus-timing, and attention. Pharmaceuticals (Basel) 14:489, 2021
  10. Lu JJ, Polgar WE, Mann A, Dasgupta P, Schulz S, Zaveri NT: Differential In vitro pharmacological profiles of structurally diverse nociceptin receptor agonists in activating G-protein and beta-arrestin signaling at the human nociceptin opioid receptor. Mol Pharmacol. 100(1):7-18, 2021
  11. Reinscheid RK, Ruzza C: Pharmacology, physiology and genetics of the neuropeptide S (NPS) system. Pharmaceuticals (Basel) 14:401, 2021
  12. Mann A, Keen AC, Mark H, Dasgupta P, Javitch JA, Canals M, Schulz S, Robert Lane J: New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep. 11(1):8288, 2021
  13. Garai S, Leo LM, Szczesniak AM, Hurst DP, Schaffer PC, Zagzoog A, Black T, Deschamps JR, Miess E, Schulz S, Janero DR, Straiker A, Pertwee RG, Abood ME, Kelly MEM, Reggio PH, Laprairie RB, Thakur GA: Discovery of a biased allosteric modulator for cannabinoid 1 receptor: Preclinical anti-glaucoma efficacy. J Med Chem. 64(12):8104-8126, 2021
  14. Bertolo A, Nouhoum M, Cazzanelli S, Ferrier J, Mariani JC, Kliewer A, Belliard B, Osmanski BF, Deffieux T, Pezet S, Lenkei Z, Tanter M: Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging. J Vis Exp. 2021 Feb 24;(168). doi: 10.3791/62267
  15. Venkataramanappa S, Schütz D, Saaber F, Kumar PA, Abe P, Schulz S, Stumm R: The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons. PLoS Genet. 17(3):e1009441, 2021
  16. Albanese V, Ruzza C, Marzola E, Bernardi T, Fabbri M, Fantinati A, Trapella C, Reinscheid RK, Ferrari F, Sturaro C, Calo G, Amendola G, Cosconati S, Pacifico S, Guerrini R, Preti D: Structure-activity relationship studies on oxazolo[3,4-a]pyrazine derivatives leading to the discovery of a novel Neuropeptide S receptor antagonist with potent in vivo activity. J Med Chem. 64(7):4089-4108, 2021
  17. Nürge B, Schulz AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A: Immunohistochemical identification of complementpeptide C5a receptor1 (C5aR1) in non-neoplastic and neoplastic human tissues. PLoS One 16(2):e0246939, 2021
  18. Reinscheid RK, Mafessoni F, Lüttjohann A, Jüngling K, Pape HC, Schulz S: Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality. Peptides 138:170506, 2021
  19. Papaioannou NE, Salei N, Rambichler S, Ravi K, Popovic J, Küntzel V, Lehmann CHK, Fiancette R, Salvermoser J, Gajdasik DW, Mettler R, Messerer D, Carrelha J, Ohnmacht C, Haller D, Stumm R, Straub T, Jacobsen SEW, Schulz C, Withers DR, Schotta G, Dudziak D, Schraml BU: Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice. Nat Commun. 12(1):464, 2021
  20. Senf K, Karius J, Stumm R, Neuhaus EM: Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium. Stem Cells 39(5):617-635, 2021
  21. Rösner E, Kaemmerer D, Neubauer E, Sänger J, Lupp A: Prognostic value of PD-L1 expression in bronchopulmonary neuroendocrine tumours. Endocr Connect. 10(2):180-190, 2021
  22. Dasgupta P, Günther T, Reinscheid RK, Zaveri NT, Schulz S: Rapid assessment of G protein signaling of four opioid receptors using a real-time fluorescence-based membrane potential assay. Eur J Pharmacol. 890:173640, 2021
  23. Sommerfeld  O, Medyukhina A,  Neugebauer S,  Ghait M,  Ulferts S, Lupp A, König R, Wetzker R, Schulz S, Figge MT,  Bauer M, Press  AT: Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis. Mol Ther. 29(1):338-346, 2021

2020

  1. Simic M, Manosalva I, Spinelli L, Gentek R, Shayan RR, Siret C, Girard-Madoux M, Wang S, de Fabritus L., Verschoor JM, Kerdiles Y, Bahenoff M, Stumm R, Golub R, van de Pavert SA: Distinct Wavews from the Hemogenic endothelium give rise to layered lymphoid tissue inducer cell ontogeny: Cell Rep. 32(6):108004, 2020
  2. Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P: The atypical chemokine receptor 3 interacts with connexin 43 inhibiting astrocytic gap junctional intercellular communication. Nat Commun. 11(1):4855, 2020
  3. Pfeil A, Busch M, Lupp A, Lehmann G, Oelzner P, Wolf G: Innovative rheumatologische und osteologische Medikation im Kontext der chronischen Niereninsuffizienz – Was ist möglich? Akt Rheumatol 45: 173–179, 2020
  4. Werner C, Lupp A, Mtuka-Pardon G, Kloos C, Wolf G, Aschenbach R, Biermann A, Freesmeyer M, Seifert P: Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet. BMC Endocr Disord. 20(1):53, 2020
  5. Werner C, Dirsch O, Dahmen U, Grimm MO, Schulz S, Lupp A: Evaluation of Somatostatin and CXCR4 Receptor Expression in a Large Set of Prostate Cancer Samples Using Tissue Microarrays and Well-Characterized Monoclonal Antibodies. Transl Oncol. 13(9):100801, 2020
  6. Ydens E, Amann L, Asselbergh B, Scott CL, Martens L, Sichien D, Mossad O, Blank T, De Prijck S, Low D, Masuda T, Saeys Y, Timmerman V, Stumm R, Ginhoux F, Prinz M, Janssens S, Guilliams M: Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury. Nat Neurosci. 23(5):676-689, 2020
  7. Werner Y, Mass E, Ashok Kumar P, Ulas T, Händler K, Horne A, Klee K, Lupp A, Schütz D, Saaber F, Redecker C, Schultze JL, Geissmann F, Stumm R: CXCR4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. Nat Neurosci. 23:351-362, 2020
  8. Mann A, Liebetrau S, Klima M, Dasgupta P, Massotte D, Schulz S: Agonist-induced phosphorylation bar code and differential activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies. Sci Rep. 10(1):8585, 2020
  9. Gillis A, Gondin AB, Kliewer A, Sanchez J, Lim HD, Alamein C, Manandhar P, Santiago M, Fritzwanker S, Schmiedel F, Katte TA, Reekie T, Grimsey NL, Kassiou M, Kellam B, Krasel C, Halls ML, Connor M, Lane JR, Schulz S, Christie MJ, Canals M: Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Sci Signal.  13(625):eaaz3140, 2020
  10. Kliewer A, Gillis A, Hill R, Schmidl F, Baily C, Kelly E, Henderson GJ, Christie MJ, Schulz S: Morphine-induced respiratory depression is independent of ß-arrestin2 signalling. Br J Pharmacol. 177:2923-2931, 2020
  11. Rudeck J, Vogl S, Heinl C, Steinfath M, Fritzwanker S., Kliewer A, Schulz S, Schönfelder G, Bert B: Analgesic treatment with buprenorphine should be adapted to the mouse strain. Pharmacol Biochem Behav. 191:172877, 2020
  12. Gillis A, Kliewer A, Kelly E, Henderson G., Christie MJ, Schulz S, Canals M: Critical assessment of G-protein-biased agonism at the µ-opioid receptor. Trends Pharmacol Sci. 41(12):947-959, 2020
  13. Groom S, Blum NK, Conibear AE, Disney A, Hill R, Husbands SM, Ki Y, Toll L, Kliewer A, Schulz S, Henderson G, Kelly E, Bailey CP: A novel G protein-biased agonist at  the µ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase. Br J Pharmacol. 2020 Nov 27. doi: 10.1111/bph.15334
  14. Reinscheid RK, Schulz S: Opioid Systems. In: Offermanns S, Rosenthal W. (eds.), Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-21573-6_108-1, 2020

2019

  1. Gunsser J, Hermann R, Roth A, Lupp A: Comprehensive assessment of tissue and serum parameters of bone metabolism in a series of orthopeadic patients. PLoS One 14(12):e0227133, 2019
  2. Herzig M, Dasgupta P, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A: Comprehensive assessment of GPR68 expression in normal and neoplastic human tissues using a novel rabbit monoclonal antibody. Int J Mol Sci. 20:5261, 2019
  3. Kajtazi Y, Kaemmerer D, Sänger J, Schulz S, Lupp A: Somatostatin and chemokine CXCR4 receptor expression in pancreatic adenocarcinoma relative to pancreatic neuroendocrine tumours. J Cancer Res Clin Oncol. 2019 Aug 26. doi: 10.1007/s00432-019-03011-0
  4. Nakai A, Fujimoto J, Miyata H, Stumm R, Narazaki M, Schulz S, Baba Y, Kumanogoh A, Suzuki K: The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. J Exp Med. 216(7):1630-1647, 2019
  5. Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S: Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Sci Signal. 12(574), 2019
  6. Mai R, Kaemmerer D, Träger T, Neubauer E, Sänger J, Baum RP, Schulz S, Lupp A: Different somatostatin and CXCR4 chemokine receptor expression in gastroenteropancreatic neuroendocrine neoplasms depending on their origin. Sci Rep. 9(1):4339, 2019
  7. Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar, P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R: ACKR3 Regulation of neuronal migration requires ACKR3 phosphorylation, but not β-Arrestin.  Cell Rep. 26(6):1473-1488.e9, 2019
  8. Kliewer A, Schmiedel F, Sianati S, Bailey A, Bateman JT, Levitt ES, Williams JT, Christie MJ , Schulz S: Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects. Nat Commun. 10(1):367, 2019
  9. Reinscheid RK, Civelli O: The history of N/OFQ and the NOP receptor. Handb Exp Pharmacol. 254:3-16, 2019

2018

  1. Abe P, Wüst HM, Arnold SJ, van de Pavert SA, Stumm R: CXCL12-mediated feedback from granule neurons regulates generation and positioning of new neurons in the dentate gyrus. Glia 66:1566-1576
  2. Chung HY, Witt C, Hurtado-Oliveros J, Wickel J, Gräler M, Lupp A, Claus R: Acid spingomylelinase inhibition stabilizes hepatic cermide content and improves hepatic biotransformation capacity in a murine model of polymiocrobial sepsis. Int J Mol Sci 19(10): E3163
  3. Günther T, Dasgupta P, Mann A, Miess E, Kliewer A, Fritzwanker S, Steinborn R, Schulz S: Targeting multiple opioid receptors - improved analgesics with reduced side effects? Br J Pharmacol 175(14):2857-2868
  4. Günther T, Tulipano G, Dournaud P, Bosquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonitsm M, Castano JP, Wester HJ, Culler M, Melmed S, Schulz S: International union of basic and clinical pharmacology. CV. Somatostatin receptors: structure, function, ligands and new nomenclature. Pharmacol 70:763-835
  5. Kan C, Ungelenk L, Lupp A, Dirsch O, Dahmen U: Ischemia-Reperfusion Injury in Aged Livers - The Energy Metabolism, Inflammatory Response, and Autophagy. Transplantation 102(3):368-377
  6. Lange F, Kaemmerer D, Behnke-Mursch J, Brück W, Schulz S, Lupp A: Differential somatostatin, CXCR4 chemokine and endothelin A receptor expression in WHO grade IIV astrocytic brain tumors. J Cancer Res Clin Oncol 144:1227-1237
  7. Loeser K, Seeman S, König S, Lenhard I, Abdal-Tawab M, Koeberle A, Werz O, Lupp A: Protective Effect of Casperome®, an orally bioavaiable frankincense extract, on lipopolysaccharide-induced systemic inflammation in mice. Front Pharmacol 9:387
  8. Miess E, Gondin S, Yousuf A, Steinborn R, Mösslein N, Yang Y, Göldner M, Ruland J, Bünemann M, Krasel C, Christie MD, Halls M, Schulz S, Canals M: Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid µ-opioid receptor desensitization: Sci Signal 11(539). pii: eaas9609
  9. Pelz T, Drose D, Fleck D, Henkel B, Ackels T, Spehr M, Neuhaus EM: An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase. PLoS One 13(2):e0191219
  10. Ruzza C, Ferrari F, Guerrini R, Marzola E, Preti D, Reinscheid RK, Calo G: Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies. Pharmacol Res Perspect 6(6):e00445
  11. Schmiedl S, Rottenkolber M,  Szymanski J, Drewelow B, Siegmund W, Hippius M,  Farker K, Guenther IR,  Hasford J, Thuermann P, German Net of Regional Pharmacovigilance Centers (NRPC): Preventable ADRs leading to hospitalization - results of a long-term prospective safety study with 6,427 ADR cases focusing on elderly patients. Exp Opinion Drug Safety 17(2):125-137
  12. Stumpf C, Kaemmerer D, Neubauer E, Sänger J, Schulz S, Lupp A: Somatostatin and CXCR4 expression patterns in adenocarcinoma and squamous cell carcinoma of the lung relative to small cell lung cancer: J Cancer Res Clin Oncol 144:1921-1932
  13. Werner C, Lupp A, Drescher R, Freesmeyer M, Mireskandari  M, Stoykow C, Bauschke A, Müller U: Morphologically `invisible’ proinsulin-secreting adenoma detected by Ga-68 Exendin-4(GLP-1 Receptor) positron emission tomography/CT.  J Med Imaging Radiat Oncol 62(3):370-374

2017

  1. Chiu YT, Chen C, Yu D, Schulz S, Liu-Chen LY: Agonist-dependent and -independent kappa opioid receptor phosphorylation showed distinct phosphorylation patterns and resulted in different cellular outcomes. Mol Pharmacol 92(5):588-600
  2. Chung HY, Kollmey AS, Schrepper A,  Kohl M,  Bläss MF, Stehr SN, Lupp A, Gräler H, Claus RA: Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction. Int J Mol Sci 18(4): pii: E839
  3. Chung HY, Witt CJ, Jbeily N, Hurtado-Oliveros J, Giszas B, Lupp A, Gräler MH, Bruns T, Stallmach A, Gonnert FA, Claus RA: Acid sphingomyelinase inhibition prevents development of sepsis sequelae in the murine liver. Sci Rep 7(1):12348. 
  4. Gelis L, Jovancevic N, Bechara F, Neuhaus EM, Hatt H.: Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis. Exp Dermatol 26(7):569-576
  5. Henkel B, Bintig W, Bhat SS, Spehr M, Neuhaus EM: NHERF1 in Microvilli of Vomeronasal sensory neurons. Chem Senses 42(1):25-35
  6. Kaemmerer D, Sänger J, Arsenic R, D'Haese JG, Neumann J, Schmitt-Graeff A,. Wirtz RM, Schulz S,  Lupp A: Evaluation of somatostatin, CXCR4 chemokine and endothelin A receptor expression in a large set of paragangliomas.  Oncotarget 8(52):89958-89969
  7. Kaemmerer D, Schindler R, Mußbach F, Dahmen U, Altendorf-Hofmann A, Dirsch O, Sänger J, Schulz S, Lupp A: Somatostatin and CXCR4 chemokine receptor expression in hepatocellular and cholangiocellular carcinomas: tumor capillaries as promising targets. BMC Cancer 17(1):896
  8. Kliewer A, Reinscheid RK, Schulz S: Emerging Paradigms of G Protein-Coupled Receptor Dephosphorylation. Trends Pharmacol Sci 38 (7):621-636
  9. Kurtenbach S, Gießl A, Strömberg S, Kremers J, Atorf J, Rasche S, Neuhaus EM, Hervé D, Brandstätter JH, Asan E, Hatt H, Kilimann MW: The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia. Sci Rep 7(1):8409. 
  10. Liu X, Si W, Garau C, Jüngling K, Pape HC, Schulz S, Reinscheid RK: Neuropeptide S precursor knockout mice display memory and arousal deficits. Eur J Neurosci 46(1), 1689-1700
  11. Luo J, Busillo JM, Stumm R, Benovic JL: G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin. Mol Pharmacol 91(6):554-566. 
  12. Mann A, Pelz T, Rennert K, Mosig A, Decker M, Lupp A: Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance. Hum Cell 30(4):267-278 
  13. Nehrlich J, Klöcking HP, Hentschel H, Lupp A: Oral Chemical Burns Reported to the Poisons Information Centre in Erfurt, Germany, from 1997 to 2014. J Burn Care Res 38(6):e913-e922.
  14. Seemann S, Zohles F, Lupp A: Comprehensive comparison of three different animal models for systemic inflammation. J Biomed Sci 24(1):60
  15. Taromi S, Lewens F, Arsenic R, Sedding D, Sänger J, Kunze A, Möbs M, Benecke J, Freitag H, Christen F, Kaemmerer D, Lupp A, Heilmann M, Lammert H, Schneider CP, Richter K, Hummel M, Siegmund B, Burger M, Briest F, Grabowski P: Proteasome inhibitor bortezomib enhances the effect of standard chemotherapy in small cell lung cancer. Oncotarget 8(57):97061-97078 
  16. Tulipano G, Faggi L, Schulz S, Spinello M, Giustina A: Effects of pasireotide (SOM230) on protein turnover and p70S6 kinase-S6 ribosomal protein signaling pathway in rat skeletal muscle cells. Endocrine  57(1):179-182
  17. Vázquez López JL, Schild L, Günther T, Schulz S, Neurath H, Becker A: The effects of kratom on restraint-stress-induced analgesia and its mechanisms of action. J Ethnopharmacol  205:178-185
  18. Zergiebel S, Fleck C, Arndt HD, Enzensperger C, Seeling A.: Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics. Drug Res (Stuttg) 67(8):466-475