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Institut für Pharmakologie und Toxikologie
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Institute of Pharmacology and Toxicology / Research / Receptor Pharmacology
Receptor Pharmacology

The group is investigating the localization, regulation and function of G protein-coupled receptors including opioid and somatostatin receptors. We are focusing on the mechanisms of agonist-induced phosphorylation and its physiological relevance for the regulation of signal transduction and tolerance.
Contact:

Prof. Dr. Stefan Schulz

Tel.: +49 3641 93 25651

Fax: +49 3641 93 25652

Receptor Pharmacology

Colleagues

apl. Prof. Dr. med. Amelie Lupp, scientist 93 25 678                                            
Dr. rer. nat. Andrea Kliewer, scientist 93 25 667
Dr. rer. nat. Elke Miess, scientist 93 25 667
Dr. rer. nat. Rainer K. Reinscheid, scientist 93 25 656
Nina Kathleen Blum; Ph.D. student 93 25 665
Sebastian Fritzwanker; Dr. rer.nat. 93 25 667, 93 25 674
Stephanie Kruck; technician 93 25 661, 674
Ulrike Schiemenz, Ulrike; technician 93 25 683, 93 25 693
Stefan Bechmann, technician 93 25 705, 93 25 653

Funded Projects

  • DFG: Genetic dissociation of G protein- and arrestin-coupled signaling at the µ-opioid receptor in vivo.
  • DFG: Regulated endocytosis and postendocytotic transport of somatostatin receptors.
  • DFG: Regulation of opioid tolerance via agonist-selective phosphorylation of endogenous opioid receptors in vivo.
  • Deutsche Krebshilfe: Somatostatin receptors as pharmacological targets for diagnostics and therapy.
  • SFB: TP C05: Real-time analysis of phosphorylation and dephosphorylation of the μ-opioid receptor.

Publications

 

  1. Gunsser J, Hermann R, Roth A, Lupp A: Comprehensive assessment of tissue and serum parameters of bone metabolism in a series of orthopeadic patients. PLoS One 14(12):e0227133, 2019
  2. Kajtazi Y, Kaemmerer D, Sänger J, Schulz S, Lupp A: Somatostatin and chemokine CXCR4 receptor expression in pancreatic adenocarcinoma relative to pancreatic neuroendocrine tumours. J Cancer Res Clin Oncol. 145(10): 2481-2493, 2019
  3. Nakai A, Fujimoto J, Miyata H, Stumm R, Narazaki M, Schulz S, Baba Y, Kumanogoh A, Suzuki K: The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. J Exp Med. 2019 May 14. pii: jem.20181494
  4. Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S: Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Sci Signal. 2019; 26;12(574). 
  5. Mai R, Kaemmerer D, Träger T, Neubauer E, Sänger J, Baum RP, Schulz S, Lupp A: Different somatostatin and CXCR4 chemokine receptor expression in gastroenteropancreatic neuroendocrine neoplasms depending on their origin. Sci Rep. 2019, 9(1):4339
  6. Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar, P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R: ACKR3 Regulation of neuronal migration requires ACKR3 phosphorylation, but not β-Arrestin.  Cell Rep. 2019, 26(6):1473-1488.e9
  7. Kliewer A, Schmiedel F, Sianati S, Bailey A, Bateman JT, Levitt ES, Williams JT, Christie MJ , Schulz S: Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects. Nat Commun. 2019, 10(1):367.

  8. Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S: International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature.  Pharmacol Rev. 2018 Oct;70(4):763-835

  9. Miess E, Gondin AB, Yousuf A, Steinborn R, Mösslein N, Yang Y, Göldner M, Ruland JG, Bünemann M, Krasel C, Christie MJ, Halls ML, Schulz S, Canals M: Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization. Sci Signal. 2018 Jul 17;11(539)

  10. Günther T, Dasgupta P, Mann A, Miess E, Kliewer A, Fritzwanker S, Steinborn R, Schulz S: Targeting multiple opioid receptors - improved analgesics with reduced side effects?  Br J Pharmacol. 2018 Jul;175(14):2857-2868

  11. Kaemmerer D, Sänger J, Arsenic R, D'Haese JG, Neumann J, Schmitt-Graeff A,. Wirtz RM, Schulz S, Lupp A: Evaluation of somatostatin, CXCR4 chemokine and endothelin A receptor expression in a large set of paragangliomas. Oncotarget. 8: 89958-89969, 2017
  12. Liu X, Si W, Garau C, Jüngling K, Pape HC, Schulz S, Reinscheid RK: Neuropeptide S precursor knockout mice display memory and arousal deficits. Eur J Neurosci. 46(1), 1689-1700, 2017
  13. Kliewer A, Reinscheid RK, Schulz S: Emerging Paradigms of G Protein-Coupled Receptor Dephosphorylation. Trends Pharmacol Sci. Jul 38; (7), 621-636, 2017