Sie verwenden einen veralteten Browser, welcher von dieser Website nicht unterstützt wird.
Mit dem Benutzen der Webseite erklären Sie sich der Nutzung von Cookies einverstanden. Weitere Pflichtangaben finden Sie in unserer Datenschutzerklärung. Akzeptieren
Zur Startseite Zur Hauptnavigation Zum Inhalt Zur Sitemap
+A-
ENDE
  menu
Klinik für Innere Medizin II
  EMERGENCY
  menu
Homepage / KIM II / Haematology and Medical Oncology / Research / Research groups
Research Groups

Outstanding science with an interdisciplinary emphasis is the hallmark of research in the Clinic for Internal Medicine II of the Jena University Hospital. This is reflected in our researchers’ participation in several joint research projects as well as in the support they receive from the German Research Council (DFG), the Federal Ministry of Education and Research (BMBF) and further foundations.

The research activities in the Department of Hematology and Medical Oncology focus on basic research into the molecular mechanisms of signal transduction in solid tumors and hematological malignancies.

In the field of translational research our scientists investigate the active principles of new substance classes for the treatment of leukemias and lymphomas as well as the diagnostic relevance of circulating tumor cells. Application of innovative therapies in multicenter trials is the focus of clinical research.

Click below for a description of each research group.

Clement Laboratory

Lab Team

Joachim Clement, Dr. rer. biol. hum. (Group Leader)

Abteilung Hämatologie und Internistische Onkologie
Klinik Innere Medizin II
Universitätsklinikum Jena
Phone.: +49 (3641) 9-325820
Fax: +49 (3641) 9-325822
email:

Jasmin Große, Bachelorstudentin
Cornelia Jörke, MTA

Research Focus

The entire nature of tumor cells and their communication with the microenvironment is complex. We are interested in the mechanism, which drive the dissemination of tumor cells from the primary tumor and allow the survival of these cells in the circulation and finally their evasion. An import role in these processes plays the bone morphogenetic protein signaling network. In collaboration with partners from academia and industry we develop new procedures to identify and isolate the entirety of circulating tumor cells from the peripheral blood. Novel photonic technologies and innovative nanomaterials contribute to a significant part to this approach.

Innovative nanomaterials in hematology and oncology

Magnetic metallic nanoparticles are widely used tools to isolate and label cells, e.g. circulating tumor cells. We are interested in understanding the cellular processes during the interaction of nanomaterials with human cells. In focus are overall cell vitality, intracellular transport mechanisms and inflammatory response. The life cycle of nanomaterials is studied in long-term cell culture models.

Identification and characterization of circulating tumor cells

The detection and identification of circulating tumor cells is challenging. The proportion of these cells is very low in the peripheral blood of tumor patients. The cell population is highly variable which requires an in-depth investigation on a single cell level. A further characterization on the molecular level is needed for future advances in cancer diagnosis and therapy.

Tumor biology of Bone Morphogenetic Proteins

Bone morphogenetic proteins are a subgroup of the Transforming Growth Factor beta superfamily. They are important regulators of embryogenesis, organogenesis and tumorigenesis. We could show that BMP-2 keeps cells in a “susceptible state” that can take various directions depending on further signals.

 

Publications (Selection)

2024

Ma, Y., Nenkov, M., Berndt, A., Abubrig, M., Schmidt, M., Sandhaus, T., Huber, O., Clement, J.H., Lang, S.M., Chen, Y. und Gaßler, N. 2024. The diagnostic value of ACSL1, ACSL4 and ACSL5 and the clinical application of ACSL inhibitor in non-small cell lung cancer. Cancers 16: 1170

2023

Mickoleit, F., Jörke, C., Richter, R., Rosenfeldt, S., Markert, S., Rehberg, I., Schenk, A.S., Bäumchen, O., Schüler, D., Clement J.H. 2023. Long-term stability, biocompatibility and magnetization of suspensions of isolated bacterial magnetosomes. Small: DOI: 10.1002/smll.202206244

Wurschi, G.W., Güllmar, D., Gaßler, N., Clement J.H., Kesselmeier, M., Müller-Wurschi, J.J., Settmacher, U., Mothes, H., Helfritzsch, H., Liebe, Y., Franiel, T., Mäurer, M.A., Ernst, T., Nicolay, N.H., Wittig, A. 2023. Planning adaptive treatment by longitudinal response assessment implementing MR imaging, liquid biopsy and analysis of microenvironment during neoadjuvant treatment of rectal cancer (PRIMO). Medicine 102(17): e33575

2022

Ernst, P., Schnöder, T.M., Huber, N., Perner, F., Jayavelu A.K., Eifert, T., Hsu C.-J., Santamaria, N.T., Crodel, C., Ungelenk, M., Hübner, C.A., Clement, J.H., Hochhaus, A., Heidel, F.H. 2022. Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms. Leukemia 36: 1843-1849

Dutz, S., Weidner, A., von der Lühe, M., Gräfe, C., Biehl, P., Demut, J., Warncke, P., Jungmann, S., Fischer, D., Schacher, F.H., Clement, J.H. 2022. Hybrid Nanomaterials of Biomolecule Corona Coated Magnetic Nanoparticles and Their Interaction with Biological Systems. Physical Sciences Reviews 7: 1311-1344; https://doi.org/10.1515/psr-2019-0110

Gräfe, C., Müller, E., Gresing, L., Weidner, A., Radon, P., Friedrich, R., Alexiou, C., Wiekhorst, F., Dutz, S. und Clement, J.H. 2022. Magnetic hybrid materials interact with biological matrices – Interaction of magnetic nanoparticles with cellular barriers. Physical Sciences Reviews 7: 1443-1500; https://doi.org/10.1515/psr-2019-0114

2021

Daum, A.K., Dittmann, J., Jansen, L., Peters, S., Dahmen, U., Heger, J., Hoppe-Seyler, F., Gille.A., Clement, J.H., Runnebaum, I.B., Dürst, M., Backsch, C. 2021. ITIH5 shows tumor suppressive properties in cervical cancer cells grown as multicellular tumor spheroids. American Journal of Translational Research 13: 10298-10314. eCollection 2021.

Mickoleit, F., Jörke, C., Geimer, S., Maier, D., Müller, J.P., Demut, J., Gräfe, C., Schüler, D., Clement, J.H. 2021. Biocompatibility, uptake and subcellular localization of bacterial magnetosomes in mammalian cells. Nanoscale Advances 3: 3799-3815; https://doi.org/10.1039/D0NA01086C

Gericke, M., Geitel, K., Jörke, C., Clement, J.H., Heinze, T. 2021. Reactive nanoparticles derived from polysaccharide phenyl carbonates. Molecules 26: 4026; https://doi.org/10.3390/molecules26134026

Gresing, L.J., Radon, P., Friedrich, R.P., Zahn, D., Raasch, M., Mosig, A.S., Dutz, S., Alexiou, C., Wiekhorst, F., Hochhaus, A., Clement, J.H. 2021. Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner. Journal of Magnetism and Magnetic Materials 521: 167535; doi.org/10.1016/j.jmmm.2020.167535

Rosenfeldt, S., Mickoleit, F., Jörke, C., Clement, J.H., Markert, S., Jérôme, V., Schwarzinger, S., Freitag, R., Schüler, D., Uebe, R., Schenk, A.S. 2021. Towards standardized purification and regeneration of bacterial magnetic nanoparticles for future in vivo applications. Acta Biomaterialia 120: 293-303

2020

Ernst, P., Press, A.T., Fischer, M., Schäfer, V., Gräfe, C., Clement, J.H., Ernst, T., Schubert, U.S., Bauer, M., Hochhaus, A. 2020. Polymethine dye-functionalized nanoparticles as a specific drug delivery system for the eradication of CML stem cells. Molecular Therapy – Oncolytics 18: 372-381

Dutz, S., Buske, N., Landers, J., Gräfe, C., Wende, H., Clement, J.H. 2020. Biocompatible magnetic fluids of Co-doped iron oxide nanoparticles with tunable magnetic properties. Nanomaterials: 10: 1019; doi.org/10.3390/nano10061019

2019

Mihajlović, J., Diehl, L.M.A., Hochhaus, A., Clement J.H. 2019. Inhibition of bone morphogenetic protein signaling reduces viability, growth and migratory potential of non-small cell lung carcinoma cells. J. Cancer Res. Clin. Oncol. 145: 2675-2687.

Alcala, N., Leblay, N., Gabriel, A., Mangiante, L., Hervas Marin, D., Giffon, T., Sertier, A.S., Ferrari, a., Derks, J., Ghantous, A., Delhomme, T.M., Chabrier, A., Cuenin, C., Abedi-Ardekani, B., Boland, A., Caux, C., Altmueller, A., Durand, G., Voegele, C., Boyault, S., Lemaitre, N., Lorimier, P., Toffart, A.C., Mc Leer, A., Solterman, A., Clement, J.H., Saenger, J., Field, J.K., Brevet, M., Blanc-Fournier, C., Galateau-Salle, F., Le Stang, N., Damiola, F., Russell, P., Wright, G., Roz, L., Lacomme, S., Vignaug, J.M., Hofman, V., Hofman, P., Brustugun, O.T., Lund-Iversen, M., Thomas de Montpreville, V., Muscarella, L.A., Graziano, P., Volante, M., Papotti, M.G., Brcic, L., Popper, H., Deleuze, J.F., Herceg, Z., Viari, A., Nuernberg, P., McKay, J.D., Sandoval, J., Hernandez-Vargas, H., Brambilla, E., Speel, E.J., Girard, N., Lantuejoul, S., Foll, M., Fernandez-Cuesta, L. 2019. Integrative and comparative analyses of multi-omics data identify clinically relevant molecular groups of pulmonary carcinoids and unveil the existence of supra-atypical carcinoids. Nature Commun. 10: 3407; doi.org/10.1038/s41467-019-11276-9

Gräfe, C., von der Lühe, M., Weidner, A., Globig, P., Clement, J.H., Dutz, S., Schacher, F.H. 2019. Protein Corona Formation and its Constitutional Changes on Magnetic Nanoparticles in Serum featuring a Polydehydroalanine Coating: Effects of Charge and Incubation Conditions. Nanotechnology 30(26):265707. doi: 10.1088/1361-6528/ab0ed0

Other publications here

Funding

Deutsche Forschungsgemeinschaft
BMBF
Dr. Rainald Stromeyer-Stiftung

Ernst Laboratory

apl. Prof., Dr. med.  Thomas Ernst (Group Leader)

Abt. Hämatologie und Internistische Onkologie
Klinik für Innere Medizin II
Universitätsklinikum Jena
email:

Team members

Dr. rer. nat. Jenny Rinke
Dr. med. Dr. rer. nat. Alexander Kaiser, M.Sc.
Dr. med. Jochen Frietsch
Sebastian Birndt
Viktoria Mathies (PhD-Doktorandin)
Saskia Nagel (Medizindoktorandin)
Theresa Deutschmann (Masterstudentin)
Anja Waldau (MTA)

Research Focus

The group is working on the molecular pathogenesis, diagnosis and therapy of myeloid leukemia with a focus on chronic myelogenous leukemia (CML) and related myeloproliferative (MPN) and myelodysplastic (MDS) diseases. In close connection between the clinic and the laboratory, several translational research projects in the fields of molecular genetics, epigenetics, clonal evolution and aging are being worked on. Using state-of-the-art sequencing techniques (pyrosequencing, next-generation sequencing) and array technology, genome-wide studies of genetic and epigenetic alterations are performed and functionally characterized in the cell model. The data obtained are analyzed and correlated with clinical parameters (e.g., response to therapy and disease progression). As a result, new prognostic markers and molecular targets can be identified, which could help to develop new targeted therapies for affected patients.

Publications (Selection; Top 10)

  1. Jayavelu AK, Schnöder TM, Perner F, Herzog C, Meiler A, Krishnamoorthy G, Huber N, Mohr J, Edelmann-Stephan B, Austin R, Brandt S, Palandri F, Schröder N, Isermann B, Edlich F, Sinha AU, Ungelenk M, Hübner CA, Zeiser R, Rahmig S, Waskow C, Coldham I, Ernst T, Hochhaus A, Jilg S, Jost PJ, Mullally A, Bullinger L, Mertens PR, Lane SW, Mann M, Heidel FH. Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature 2020; 588(7836):157-163.
  2. Kaiser A, Schmidt M, Huber O, Frietsch JJ, Scholl S, Heidel FH, Hochhaus A, Müller JP, Ernst T. SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders. Leukemia 2020; 34(8):2206-2216.
  3. Branford S, Kim DDH, Apperley JF, Eide CA, Mustjoki S, Ong ST, Nteliopoulos G, Ernst T, Chuah C, Gambacorti-Passerini C, Mauro MJ, Druker BJ, Kim DW, Mahon FX, Cortes J, Radich JP, Hochhaus A, Hughes TP; International CML Foundation Genomics Alliance. Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia. Leukemia 2019; 33(8):1835-1850.
  4. Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell 2018;1 73(2):470-484.
  5. Rinke J, Müller JP, Blaess MF, Chase A, Meggendorfer M, Schäfer V, Winkelmann N, Haferlach C, Cross NCP, Hochhaus A, Ernst T. Molecular characterization of EZH2 mutant patients with myelodysplastic/myeloproliferative neoplasms. Leukemia 2017; 31(9):1936-1943.
  6. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 2017; 542(7642):479-483.
  7. Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nature Medicine 2016; 22(4):379-387.
  8. Schmidt M, Rinke J, Schäfer V, Schnittger S, Kohlmann A, Obstfelder E, Kunert C, Ziermann J, Winkelmann N, Eigendorff E, Haferlach T, Haferlach C, Hochhaus A, Ernst T. Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status. Leukemia 2014; 28(12):2292-2299.
  9. Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, Waghorn K, Zoi K, Ross FM, Reiter A, Hochhaus A, Drexler HG, Duncombe A, Cervantes F, Oscier D, Boultwood J, Grand FH, Cross NCP. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nature Genetics 2010; 42(8):722-726.
  10. Jones AV, Kreil S, Zoi K, Waghorn K, Curtis C, Zhang L, Score J, Seear R, Chase AJ, Grand FH, White H, Zoi C, Loukopoulos D, Terpos E, Vervessou EC, Schultheis B, Emig M, Ernst T, Lengfelder E, Hehlmann R, Hochhaus A, Oscier D, Silver RT, Reiter A, Cross NC: Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 2005; 106:2162-2168.

Theses and Dissertations

If you are interested in doing your experimental doctoral dissertation with us, please contact Prof. Thomas Ernst.

Funding

Bundesministerium für Bildung und Forschung (BMBF), Deutsche José-Carreras-Leukämie-Stiftung, Hector-Stiftung

Hilgendorf Laboratory

Prof. Dr. Inken Hilgendorf (Group leader)
Klinik für Innere Medizin II
Abteilung Hämatologie und Internistische Onkologie
Universitätsklinikum Jena

E-Mail:  

Group members

Maria Günther (Lebensmitteltechnologin, Diätassistentin)
Anne Krüger (Dipl.-Psychologin)
Laura Lämmer (Doktorrandin)
Peter Lorenz (Sportwissenschaftler)
Jan Morf (Doktorrand)
Kristin Pulewka (Dipl.-Psychologin)
Andreas Wittwer (Doktorrand)

Research Focus

The treatment of malignant haematological or oncological diseases can contribute to the occurrence of long-term side effects. These long-term consequences often go hand in hand with an impaired quality of life for those affected.

Adolescents and young adults (AYA) are particularly affected because of their young age at the time of illness. Our investigations focus on long-term consequences after tumor therapy or blood stem cell transplantation in young adulthood as well as on the effectiveness of preventive measures (e.g. within the framework of theCARE for CAYA project).

Another focus of interest is immune reconstitution and the therapy of long-term consequences (e.g. chronic GvHD) after allogeneic blood stem cell transplantation.

Publications

2019

• Gebauer J, Hilgendorf I, Koch B-, Langer T. Neue Strukturen in der Betreuung und Nachsorge junger Krebspatienten. Oncol Res Treat. 42(suppl 3):21-26.2019
• Battipaglia G, Labopin M, Kröger N, Vitek A, Afanasyev B, Hilgendorf I, Schetelig J, Ganser A, Blaise D, Itälä-Remes M, Passweg JR, Bonifazi F, Finke J, Ruggeri A, Nagler A, Mohty M. Post-Transplant Cyclophosphamide versus Antithymocyte Globulin in HLA-Mismatched unrelated Donors transplantation. Blood 2019 Jul 3. pii: blood.2019000487. doi: 10.1182/blood.2019000487. [Epub ahead of print]
• Lamby P, Wolff D, Mielke S, Grigoleit GU, Ljungman P, Hilgendorf I, Holler E, Holler B, Weber D, Herr W, Schiltz D, Klein S, Graf S, Bjornhagen-Safwenberg V, Dolderer J, Prantl L. Allogeneic donor split skin grafts for treatment of refractory ulcers in cutaneous chronic Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation – a retrospective analysis on 7 patients. Ann Hematol 98(8):1867-1875.2019.
• Wolff D, Hilgendorf I, Wagner-Drouet E, Jedlickova Z, Ayuk F, Zeiser R, Schäfer-Eckart K, Gerbitz A, Stadler M, Klein S, Middeke JM, Lawitschka A, Winkler J, Halter J, Holler E, Kobbe G, Stelljes M, Ditschkowski M, Greinix H. Changes in immunosuppressive treatment of chronic graft-versus-host disease - comparison of 2 surveys within allogeneic hematopoietic stem cell transplant centers in Germany, Austria and Switzerland. Biol Blood Marrow Transplant. 2019 Mar 12. pii: S1083-8791(19)30154-5. doi: 10.1016/j.bbmt.2019.03.003. [Epub ahead of print]
• Brioli A, Klaus M, Sayer H, Scholl S, Ernst T, Hilgendorf I, Scherag A, Yomade O, Schilling K, Hochhaus A, Mügge LO, von Lilienfeld-Toal M. The risk of infections in multiple myeloma before and after the advent of novel agents: a 12-year survey. Ann Hematol. 98(3):713-722. 2019.
• Frietsch JJ, Michel D, Stamminger T, Hunstig F, Birndt S, Schnetzke U, Scholl S, Hochhaus A, Hilgendorf I. In Vivo Emergence of UL56 C325Y Cytomegalovirus Resistance to Letermovir in a Patient with Acute Myeloid Leukemia after Hematopoietic Cell Transplantation. Mediterr J Hematol Infect Dis. 2019 Jan 1;11(1):e2019001. doi: 10.4084/MJHID.2019.001. eCollection 2019.

2018

• Wang L, Ni M, Hückelhoven-Krauss A, Sellner L, Hoffmann JM, Neuber B, Luft T, Hegenbart U, Schönland S, Kleist C, Sill M, Chen B, Wuchter P, Eckstein V, Krüger W, Hilgendorf I, Yerushalmi R, Nagler A, Müller-Tidow C, Ho AD, Dreger P, Schmitt M, Schmitt A. Modulation of B Cells and Homing Marker on NK Cells Through Extracorporeal Photopheresis in Patients With Steroid-Refractory/Resistant Graft-Vs.-Host Disease Without Hampering Anti-viral/Anti-leukemic Effects. Front Immunol. 9: 1-15. 2018
• Kühl R, Meier S, Baeurle M, Wolff D, Lawitschka A, Halter J, Bertz H, Hilgendorf I. Sport- und physiotherapeutische Maßnahmen zur Behandlung der chronischen Graft-versus-Host-Krankheit. Phys Med Rehab Kuror. 28(04): 224-230. 2018
• Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med. 24(3):282-291.2018. Erratum in Nat Med. 24(4):526.2018.
• Schumacher H, Stüwe S, Kropp P, Diedrich D, Freitag S, Greger N, Junghanss C, Freund M, Hilgendorf I. A prospective, randomized evaluation of the feasibility of exergaming on patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant. 53(5):584-90. 2018
• van Gorkom G, van Gelder M, Eikema DJ, Blok HJ, van Lint MT, Koc Y, Ciceri F, Beelen D, Chevallier P, Selleslag D, Blaise D, Foá R, Corradini P, Castagna L, Moreno C, Solano C, Müller LP, Tischer J, Hilgendorf I, Hallek M, Bittenbring J, Theobald M, Schetelig J, Kröger N; CLL subcommittee; Chronic Malignancies Working Party of the EBMT. Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT. Bone Marrow Transplant. 53(3):255-263.2018.
• Hilgendorf I. Langzeitfolgen und Nachsorge nach Blutstammzelltransplantation. Spectrum Onkologie 7: 32-34. 2018.

2017

• Pulewka K, Wolff D, Herzberg PY, Greinix H, Heussner P, Mumm FHA, von Harsdorf S, Rieger K, Hemmati P, Hochhaus A, Hilgendorf I. Physical and psychosocial aspects of adolescent and young adults after allogeneic hematopoietic stem-cell transplantation: results from a prospective multicenter trial. J Cancer Res Clin Oncol. 143(8):1613-1619. 2017.
• Hilgendorf I, Greinix H, Halter J, Lawitschka A, Wolff D. Vaccination of allogeneic
hematopoietic stem cell transplant recipients-what should be considered? Ann Hematol. 96(4):701-702. 2017.
• Fischer M, Schnetzke U, Spies-Weisshart B, Walther M, Fleischmann M, Hilgendorf I, Hochhaus A, Scholl S. Impact of FLT3-ITD diversity on response to induction chemotherapy in patients with acute myeloid leukemia. Haematologica. 102(4):e129-e131. 2017.
• Fleischmann M, Schnetzke U, Schrenk KG, Schmidt V, Sayer HG, Hilgendorf I, Hochhaus A. Scholl S. Outcome of FLT3-ITD-positive acute myeloid leukemia: impact of allogeneic stem cell transplantation and tyrosine kinase inhibitor treatment. J Cancer Res Clin Oncol. 143(2):337-345. 2017
• Quidde J, Koch B, Salchow J, Jensen W. von Gundherr J, Escherich G, Rutkowski S, Schulz-Kindermann F, Bergelt C, Bokemeyer C, Sokalska-Duhme M, Bielack S, Calaminius G, Classen CF, Rössig C, faber J, Faller H, Hilgendorf I, Langer T, Metzler M, Schuster S, Niemeyer C, Pierce A, Reinhardt D, Sander A, Köhler M, Stein A. Das CARE for CAYA-Programm. Präventionskonzept für junge Menschen nach Krebserkrankung. FORUM 32: 479-484. 2017

2016

• Winkelmann N, Desole M, Hilgendorf I, Ernst T, Sayer HG, Kunert C, Mügge LO, Hochhaus A, Scholl S. Comparison of two dose levels of cyclophosphamide for successful stem cell mobilization in myeloma patients. J Cancer Res Clin Oncol. 142(12):2603-2610. 2016.
• Casalegno-Garduño R, Schmitt A, Spitschak A, Greiner J, Wang L, Hilgendorf I, Hirt C, Ho AD, Freund M, Schmitt M. Immune responses to WT1 in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation. Int J Cancer. 138(7):1792-801. 2016.

2015

• Hautmann AH, Wolff D, Hilgendorf I, Fehn U, Edinger M, Hoffmann P, Herr W, Kölbl O, Holler B, Sporrer D, Holler E, Hautmann MG. Total nodal irradiation in patients with severe treatment-refractory chronic graft-versus-host disease after allogeneic stem cell transplantation: Response rates and immunomodulatory effects. Radiother Oncol. 116(2):287-93. 2015.
• Richter D, Koehler M, Friedrich M, Hilgendorf I, Mehnert A, Weißflog G. Psychosocial interventions for adolescents and young adult cancer patients: A systematic review and meta-analysis. Crit Rev Oncol Hematol. 95(3):370-86. 2015.
• Geue K, Schmidt R, Nielsen T, Hilgendorf I, Kropp P, Richter D, Sender A, Friedrich M, Brähler E, Stöbel-Richter Y. The extension of the Leipzig questionnaire of motives to have a child (LKM) for use in oncology--test construction and psychometric review. Psychother Psychosom Med Psychol. 65(3-4):119-25. 2015.
• Lorenz K, Rommel K, Mani J, Jin N, Hilgendorf I, Ho AD, Freund M, Schmitt M, Schmitt A. Modulation of lymphocyte subpopulations by extracorporeal photopheresis in patients with acute GvHD or graft rejection. Leuk Lymphoma. 56:671-5. 2015.
• Hilgendorf I, Greinix H, Halter JP, Lawitschka A, Bertz H, Wolff D. Long-term follow up after allogeneic stem cell transplantation. Dtsch Arztebl Int. 112(4): 51-58, 2015

Theses and Dissertations

If you are interested in doing your experimental doctoral dissertation with us, please contact Inken Hilgendorf

Funding

• G-BA
• Hector-Stiftung

Huebner Laboratory

Lab team

Prof. Dr. med Jutta Huebner, Team Leader

Team members:

Emadaldin Ahmadi, Dr. phil.
Jennifer Dörfler, M.Sc.
Lena Josfeld, M.Sc.
Viktoria Mathies, M.Sc.
Christina Mensger, Dr. rer. nat.
Annika Momberg, Dipl.-Psych.
Sarah Salomo, M.Sc.

Research Focus

Integrative oncology: what supports patients during and after therapy; Complementary and alternative medicine: how can we differentiate meaningful evidence-based methods from dangerous alternative medicine. Information for patients - how can we give patients good information. Which formats can we use and how.

Publications (Top 10)

  1. Ruetters D, Keinki C, Schroth S, Liebl P, Huebner J.  Is there evidence for a better health care for cancer patients after a second opinion? – a systematic review; J Cancer Res Clin Oncol 2016 Jul;142(7):1521-8
  2. Fuchs T, Hanaya H, Seilacher E, Koester MJ, Keinki C, Liebl P, Huebner J. Information Deficits and Second Opinion Seeking - A Survey on Cancer Patients. Cancer Invest. 2016 Nov 28:1-8. DOI: 10.1080/07357907.2016.1242012
  3. Lang V., Walter S., Fessler J, Koester MJ, Ruetters D, Huebner J. The role of the general practitioner in cancer care: a survey of the patients’ perspective; J Cancer Res Clin Oncol 2017;  143:895-904
  4. Ebel MD, Stellamanns J, Keinki C, Rudolph I, Huebner J. Cancer patients and the internet: a survey among German cancer patients; J Cancer Educ. 2017; 32:503–508
  5. Boehme C, Baron von Osthoff M, Frey K, Huebner J. Development of a Rating Tool for Mobile Cancer Apps: Information Analysis and Formal and Content-Related Evaluation of Selected Cancer Apps; Canc Educ; DOI 10.1007/s13187-017-1273-9
  6. Huebner J, Prott FJ, Muecke R, Stoll C, Buentzel J, Muenstedt K, Micke O. Economic Evaluation of Complementary and Alternative Medicine in Oncology: Is There a Difference Compared to Conventional Medicine? Med Princ Pract. 2017;26(1):41-49. doi: 10.1159/000450645.
  7. Firkins R, Eisfeld H, Keinki C, Buentzel J, Hochhaus A, Schmidt T, Huebner J. The use of complementary and alternative medicine by patients in routine care and the risk of interactions; J Cancer Res Clin Oncol 2018;144:551-557
  8. Keinki c, Rudolph I, Ruetters D, Kuenzel U, Lobitz J, Schaefer M,  Hanaya H, Huebner J. The Quality of Patient Information Booklets for Cancer Patients—an Evaluation of Free Accessible Material in German Language J Canc Educ 2018;33(5):1132–1139
  9. Freuding M, Keinki C, Micke O, Buentzel J, Huebner J. Mistletoe in oncological treatment: a systematic review; Part 1: survival and safety; J Cancer Res Clin Oncol 2019;145:695–707
  10. Braun LA, Zomorodbakhsch B, Keinki C, Huebner J. Information needs, communication and usage of social media by cancer patients and their relatives; J Cancer Res Clin Oncol 2019; 145:1865-1875

Schenk Laboratory

Leitung:

Dr. Tino Schenk
Klinik für Innere Medizin II
Universitätsklinikum Jena
Abteilung Hämatologie und Internistische Onkologie

Labor im
Institut für Molekulare Zellbiologie
Zentrum für Molekulare Biomedizin (CMB)
Hans-Knöll-Strasse 2
07745 Jena

E-Mail:  

Mitarbeiter:

Jacqueline Schütt (Masterstudentin)
Sergei Silaev (Masterstudent)
Franziska Fiedler (Doktorandin, Medizin) 
Clara Stanko (PhD-Studentin)

© Lander/Magdeburg
© Lander/Magdeburg

Forschungsgebiet

Unsere Arbeitsgruppe beschäftigt sich mit der Erforschung genetischer und epigenetischer Faktoren, welche dem Differenzierungsblock leukämischer Stammzellen und Blasten zugrunde liegen.  Der Schwerpunkt richtet sich hierbei auf der Freisetzung des kurativen Potenzials der All-trans-Retinsäure (ATRA) in der Akuten Myeloischen Leukämie (AML). In aktuellen Forschungsvorhaben sollen die Mechanismen der pro-differenzierenden Wirkung von Inhibitoren der Histon H3 Lysin 4 Demethylase LSD1 in Kombination mit ATRA entschlüsselt und neue epigenetische Ziele identifiziert werden, welche die ATRA vermittelte Aufhebung des Differenzierungsblocks der AML ermöglichen. 

Publikationen

M. Kahl, A. Brioli, M. Bens, F. Perner, A. Kresinsky, U. Schnetzke, A. Hinze, Y. Sbirkov, S. Stengel, G. Simonetti, G. Martinelli, K. Petrie, A. Zelent, F. Boehmer, M. Groth, T. Ernst, F. Heidel, S. Scholl, A. "Hochhaus, and T. Schenk, “The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML”, Leukemia, Epub ahead of print, https://doi.org/10.1038/s41375-019-0581-y.

A. Steube, T. Schenk, A. Tretyakov, and H. P. Saluz, “High-intensity UV laser ChIP-seq for the study of protein-DNA interactions in living cells”, Nature Communications, vol. 8, article 1303, Nov. 2017.

S. Göllner, T. Oellerich, S. Agrawal-Singh, T. Schenk, H.-U. U. Klein, C. Rohde, C. Pabst, T. Sauer, M. Lerdrup, S. Tavor, F. Stölzel, S. Herold, G. Ehninger, G. Köhler, K.-T. T. Pan, H. Urlaub, H. Serve, M. Dugas, K. Spiekermann, B. Vick, I. Jeremias, W. E. Berdel, K. Hansen, A. Zelent, C. Wickenhauser, L. P. Müller, C. Thiede, and C. Müller-Tidow, “Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia”, Nature Medicine, vol.23, pp. 69-78, Jan 2017.

T. Schenk, S. Stengel, and A. Zelent, “Unlocking the potential of retinoic acid in anticancer therapy.”, British Journal of Cancer, 111(11):2039-45, Nov. 2014.

T. Schenk, W. C. Chen, S. Göllner, L. Howell, L. Jin, K. Hebestreit, H.-U. Klein, A. C. Popescu, A. Burnett, K. Mills, R. a Casero, L. Marton, P. Woster, M. D. Minden, M. Dugas, J. C. Y. Wang, J. E. Dick, C. Müller-Tidow, K. Petrie, and A. Zelent, “Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.”, Nature Medicine, vol. 18, no. 4, pp. 605–11, Apr. 2012.

C. L. Alvares, T. Schenk, S. Hulkki, T. Min, G. Vijayaraghavan, J. Yeung, D. Gonzalez, C. W. E. So, M. Greaves, I. Titley, K. Bartolovic, and G. Morgan, “Tyrosine kinase inhibitor insensitivity of non-cycling CD34+ human acute myeloid leukaemia cells with FMS-like tyrosine kinase 3 mutations”, British Journal of Haematology, vol. 154, no. 4, pp. 457–65, Aug. 2011.

E. F. Farias, K. Petrie, B. Leibovitch, J. Murtagh, M. B. Chornet, T. Schenk, A. Zelent, and S. Waxman, “Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells.,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 26, pp. 11811–6, Jun. 2010.

T. Schenk, S. Stengel, S. Goellner, D. Steinbach, and H. P. Saluz, “Hypomethylation of PRAME is responsible for its aberrant overexpression in human malignancies,” Genes, Chromosomes & Cancer, vol. 804, no. April, pp. 796–804, 2007.

S. Goellner, D. Steinbach, T. Schenk, B. Gruhn, F. Zintl, E. Ramsay, and H. P. Saluz, “Childhood acute myelogenous leukaemia: association between PRAME, apoptosis- and MDR-related gene expression.,” European journal of cancer (Oxford, England : 1990), vol. 42, no. 16, pp. 2807–14, Nov. 2006.

Wissenschaftliche Arbeiten

Bei Interesse an einer experimentellen Bachelor- oder Masterarbeit schreiben sie bitte eine E-Mail an oder stellen sich persönlich im Labor vor.

 

Drittmittelförderung

Deutsche Forschungsgemeinschaft, IZKF, Deutsche Krebshilfe
Landesgraduiertenstipendium (Faezeh Zadegan) 

Scholl Laboratory

Schrenk Laboratory

Lab members

PD Dr. med. Karin Schrenk, geb. Wirth (Group Leader)
Klinik für Innere Medizin II
Abteilung Hämatologie und Internistische Onkologie
Universitätsklinikum Jena

email:

Lab Team

Nicole Renger, BSc
Johanna Apel, MSc
Sarah Werner, cand.med.

Research Focus

Während der Zellteilung durchlaufen alle Zellen bestimmte Phasen des Zellzyklus. Zu diesen Zeitpunkten erfolgen wichtige Schritte wie z.B. die Verdopplung der DNA in der S-Phase oder die Trennung der Schwesterchromatiden in der Mitose. Fehler während des Zellzyklus führen zum Arrest der Zellteilung oder zur Entstehung von Tumorzellen. Die Arbeitsgruppe untersucht die wichtigen Zellzyklusregulatoren Anaphase-Promoting Complex (APC) und Separase. Die Ubiquitinligase Anaphase-Promoting Complex/ Cyclosome (APC/C) ist durch Ubiquitinierung regulatorischer Proteine für den geordneten Ablauf des Zellzyklus von zentraler Bedeutung. Darüber hinaus hat der APC/C auch Funktionen in postmitotischen Zellen und verhindert den unkontrollierten Wiedereintritt von ruhenden Zellen in den Zellzyklus. Auch an Zellzyklus unabhängigen Regulationsmechanismen ist der APC/C beteiligt. Im Gegensatz zur bekannten Funktion im Zellzyklus sind die Zellzyklus unabhängigen Funktionen von APC/C weitgehend ungeklärt. Die Protease Separase spaltet in der Mitose den Cohesin Complex und ermöglicht damit die Trennung der Schwesterchromatiden. Das Verständnis grundlegender Mechanismen der Zellzyklusregulation kann auf Leukämiezellen übertragen werden und zu neuen Therapieoptionen führen.

Publications (selection)

2015

Schrenk KG, Frosinski J, Scholl S, Otto S, La Rosée P, Hochhaus A and Pletz M. Successful treatment of neutropenic MRSA bacteremia with septic superior vena cava thrombus and cerebral embolism using high-dose daptomycin. 2015. Ann Hematol. Epub ahead of print.

Schrenk KG, Katenkamp K, Felber, J, Mügge LO, Hochhaus A. and Scholl S. Lower gastrointestinal bleeding in a patient with Crohn´s disease and plasma cell leukemia in remission. 2015. Ann Hematol 94(12): 2063-5.

Schrenk KG, Schnetzke U, Stegemann K, von Lilienfeld-Toal M, Hochhaus A and Scholl S. 2015. Efficacy of antifungal prophylaxis with oral suspension posaconazole during induction chemotherapy of acute myeloid leukemia. 2015. J.Cancer Res.Clin.Oncol 141(9):1661-8.

2014

Schnetzke U, Spies-Weisshart B, Yomade O, Fischer M, Rachow T, Schrenk K, Glaser  A, von Lilienfeld-Toal M, Hochhaus A and Scholl, S. 2014. Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the risk of infectious complications in patients with acute myeloid leukemia. Genes Immun 16(1): 83-88.

Schnetzke U, Fix P, Spies-Weisshart B, Schrenk K, Glaser A, Fricke H-J, La Roseé P, Hochhaus A and Scholl S. 2014. Efficacy and feasibility of cyclophosphamide combined with intermediate-dose or high-dose cytarabine for relapsed and refractory acute myeloid leukemia (AML). J.Cancer Res.Clin.Oncol. 140(8): 1391-1397.

Schnetzke U, Schrenk K, Spies-Weisshart B, Kunert C, Hochhaus A and Scholl S. 2014. Different clones of acute leukemia after successful treatment of Hodgkin’s disease. Ann.Hematol. 93(12): 2077-2079.

Publications prior to 2013

Schrenk KG, Krokowski M, Feller AC, Mügge L-O, Oelzner P, Wolf P, Hochhaus A and Neumann T. 2013.Clonal T-LGL population mimicking leukemia in Felty’s Syndrome- part of a continuous spectrum of T-LGL proliferations? Ann.Hematol.92(7):985-987.

Kudo NR, Wassmann K, Anger M, Schuh M, Wirth KG, Xu H, Helmhart W, Kudo H, Mckay M, Maro B, Ellenberg J, de Boer P and Nasmyth K. 2006. Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell 126(1): 135-146.

Wirth KG, Wutz G, Kudo NR Desdouets C, Zetterberg A, Taghybeeglu S, Seznec J, Ducos GM, Ricci R, Firnberg N, Peters JM and Nasmyth K. 2006. Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J. Cell Biol. 172 (6): 847-860.

Wirth KG, Ricci R, Giménez-Abián JF, Taghybeeglu S, Kudo NR, Jochum W, Vasseur-Cognet M and Nasmyth K. 2004. Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev. 18(1): 88-98.

Theses and Dissertations

Masterarbeit zu vergeben.  Thema: „Charakterisierung der Funktion des Anaphase-Promoting Complex/Cyclosome in hämatopoetischen Zellen“. Beginn 09/2016. Kontakt:

von Lilienfeld-Toal Laboratory