CV
| 1996 | University-entrance diploma in Bacau (Romania) |
| 1996-2000 | Biology studies at the "Al.I.Cuza"-University in Iasi (Romania) |
| 1999-2000 | Diploma thesis at the "Al.I.Cuza"-University in Iasi (Romania) |
| 2000-2002 | Specialisation course "Microbiological Techniques" in Iasi (Romania) |
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2001-2002 |
Erasmus Scholarship, Institute of Biology II, Albert Ludwigs University Freiburg im Br.
Title: “Study of acetate assimilation by Rhodobacter sp.”
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| 2002-2005 | PhD student funded by the Graduiertenkolleg "Biomolekulare Schalter" at the Institute of Physiology II, University Hospital Jena |
| 2005 | Dissertation "The gating kinetics of CNG channels studied with cyclic nucleotide concentration jumps" |
| since 2005 | Postdoc at the Institute of Physiology II, University Hospital Jena |
Research
- Activation gating and ligand binding of cyclic-nucleotide gated (CNG) channels
- Contribution of each individual subunit of the heterotetrameric olfactory CNGA2:A4:B1b channel to the activation mechanism
Skills
- Patch-Clamp Technique
- Confocal Patch-Clamp Fluorometry (confocal PCF)
- Flash Photolysis
- Gel Electrophoresis
- Blotting methods
- FRET
Publications
Nache, V., Wongsamitkul, N., Kusch, J., Zimmer, T., Schwede, F., and Benndorf, K. (2016)
Sci. Rep. 6, 29378
Wongsamitkul, N., Nache, V., Eick, T., Hummert, S., Schulz, E., Schmauder, R., Schirmeyer, J., Zimmer, T., and Benndorf, K. (2016)
Sci. Rep. 6, 20974
Nache, V., Eick, T., Schulz, E., Schmauder, R., and Benndorf, K. (2013)
Nat. Commun. 4, 2864
Nache, V., Zimmer, T., Wongsamitkul, N., Schmauder, R., Kusch, J., Reinhardt, L., Bönigk, W., Seifert, R., Biskup, C., Schwede, F., and Benndorf, K. (2012)
Sci. Signal. 5, ra48
Kusch, J., Thon, S., Schulz, E., Biskup, C., Nache, V., Zimmer, T., Seifert, R., Schwede, F., and Benndorf, K. (2012)
Nat. Chem. Biol. 8, 162-9
Kusch, J., Zimmer, T., Holschuh, J., Biskup, C., Schulz, E., Nache, V., and Benndorf, K. (2010)
Biophys. J. 99, 2488-96
Kusch, J., Biskup, C., Thon, S., Schulz, E., Nache, V., Zimmer, T., Schwede, F., and Benndorf, K. (2010)
Neuron 67, 75-85
Nache, V., Kusch, J., Biskup, C., Schulz, E., Zimmer, T., Hagen, V., and Benndorf, K. (2008)
Biophys. J. 15, 2750-8
Biskup, C., Kusch, J., Schulz, E., Nache, V., Schwede, F., Lehmann, F., Hagen, V., and Benndorf, K. (2007)
Nature 446, 440-3
Nache, V., Kusch, J., Hagen, V., and Benndorf, K. (2006)
Biophys. J. 90, 3146-54
Nache, V., Schulz, E., Zimmer, T., Kusch, J., Biskup, C., Koopmann, R., Hagen, V., and Benndorf, K. (2005)
J. Physiol. 569, 91-102
Hagen, V., Dekowski, B., Nache, V., Schmidt, R., Geissler, D., Lorenz, D., Eichhorst, J., Keller, S., Kaneko, H., Benndorf, K., and Wiesner, B. (2005)
Angew. Chem. Int. Ed. Engl. 44, 7887-91
Funding and Awards
| 2001/2002 | Socrates/Erasmus-Stipendium Albert-Ludwigs-Universität Freiburg im Br. |
| 2010 | Programm zur Förderung der Drittmittelfähigkeit |
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2011
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Poster Prize (90th Meeting of the German Physiological Society, Regensburg)
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| 2012 | Poster Prize (91st Meeting of the German Physiological Society, Dresden) |
| 2014 | Poster Prize (93rd Annual Meeting Deutsche Physiologische Gesellschaft, Mainz) |
| 2015-2019 |
DFG Grant within Collaborative Research Center/Transregio 166
Title: “Elucidating assembly, ligand binding and gating of heterotetrameric CNG channels by FRET”
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| 2020-2023 |
DFG Grant “Characterization of cyclic nucleotide-induced activation of CNG channels in the context of a potential therapy for retinitis pigmentosa.”
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Teaching
- Practical course „Physiology for human medicine, dentistry and pharmacy"
- Seminar "Physiology for human medicine "
- Seminar "Physiology for dentistry"
- Seminar "Clinical Physiology - ECG"
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Seminar „Clinical Physiology - Diving and Climbing”
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Lecture “Heart”
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Supervising of the PhD project “Translation of ligand binding to activation in olfactory CNG channels” (2012-2015)