Publications

Neu CT, Weilepp L, Bork K, Gesper A, Horstkorte R. GNE deficiency impairs Myogenesis in C2C12 cells and cannot be rescued by ManNAc supplementation. 2024. Glycobiology. cwae004. doi: 10.1093/glycob/cwae004. 

Xavier G, Navarrete Santos A, Hartmann C, Santoro ML, Flegel N, Reinsch J, Majer A, Ehrhardt T, Pfeifer J, Simm A, Hollemann T, Belangero SI, Rujescu D, Jung M. 2024. Comparison of Extracellular Vesicles from Induced Pluripotent Stem Cell-Derived Brain Cells. Int J Mol Sci. 22;25(7):3575. doi: 10.3390/ijms25073575. PMID: 38612385; PMCID: PMC11011287.

Franzka P, Mittag S, Chakraborty A, Huber O, Hübner CA. 2024. Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity. Front Mol Neurosci. 24;17:1375297. doi: 10.3389/fnmol.2024.1375297. PMID: 38979475; PMCID: PMC11228364.

Manzolillo A, Gresing L, Hübner CA, Franzka P. Knockdown of INPP5K compromises the differentiation of N2A cells. 2024. Front Mol Neurosci. 15;17:1356343. doi: 10.3389/fnmol.2024.1356343. PMID: 38559586; PMCID: PMC10979461.

Schurig MK, Umeh O, Henze H, Jung MJ, Gresing L, Blanchard V, von Maltzahn J, Hübner CA, Franzka P. Consequences of GMPPB deficiency for neuromuscular development and maintenance. 2024. Front Mol Neurosci. 14;17:1356326. doi: 10.3389/fnmol.2024.1356326. PMID: 38419795; PMCID: PMC10899408.

Erler K, Krafczyk N, Steinbrenner H, Klotz LO. 2024. Selective activation of cellular stress response pathways by fumaric acid esters. FEBS Open Bio. 24. doi: 10.1002/2211-5463.13833. PMID: 38794848.

Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli TM, Notopoulou S, Dykstra W, Oehler D, López-Calcerrada S, Mlody B, Otto M, Wu H, Richter Y, Roth P, Anand R, Kulka LAM, Meierhofer D, Glazar P, Legnini I, Telugu NS, Hahn T, Neuendorf N, Miller DC, Böddrich A, Polzin A, Mayatepek E, Diecke S, Olzscha H, Kirstein J, Ugalde C, Petrakis S, Cambridge S, Rajewsky N, Kühn R, Wanker EE, Priller J, Metzger JJ, Prigione A. 2024. Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Nat Commun. 15(1):7027. doi: 10.1038/s41467-024-51216-w. PMID: 39174523; PMCID: PMC11341898.

Winterhalter PR, Georgevici AI, Gharpure NJ, Szabó G, Simm A. 2024. The circadian rhythm: A key variable in aging? Aging Cell. e14268. doi: 10.1111/acel.14268. Epub ahead of print. PMID: 39078410.

Erler K, Krafczyk N, Steinbrenner H, Klotz LO. 2024. Selective activation of cellular stress response pathways by fumaric acid esters. FEBS Open Bio. 1230-1246. doi: 10.1002/2211-5463.13833. Epub 2024 May 24. PMID: 38794848; PMCID: PMC11301269.

Zibrova D, Ernst T, Hochhaus A, Heller R. 2024. The BCR::ABL1 tyrosine kinase inhibitors ponatinib and nilotinib differentially affect endothelial angiogenesis and signalling. Mol Cell Biochem. doi: 10.1007/s11010-024-05070-5. Epub ahead of print. PMID: 39009935.

Fanaei-Kahrani Z, Kaether C. 2024. Asparagine614 Determines the Transport and Function of the Murine Anti-Aging Protein Klotho. Cells. 13(20):1743. doi: 10.3390/cells13201743. PMID: 39451260; PMCID: PMC11506777.

Hussein RA, Ahmed M, Heinemann SH. 2023. Selenomethionine mis-incorporation and redox-dependent voltage-gated sodium channel gain of function. J Neurochem. Oct;167(2):262-276. doi: 10.1111/jnc.15957.

Franzka P, Schüler SC, Kentache T, Storm R, Bock A, Katona I, Weis J, Buder K, Kaether C, Hübner CA. 2023. Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex. Biomed. 11, no. 1: 146. https://doi.org/10.3390/biomedicines11010146.

Volmer J, Arabi SH, Henning C, Glomb MA, Hinderberger D. 2023. Tuning Human Serum Albumin (HSA) Hydrogels through Albumin Glycation. Macromol Biosci. 23(3):e2200487. doi: 10.1002/mabi.202200487. Epub 2023 Jan 11. PMID: 36543753.

Piskovatska V, Navarrete Santos A, Kalies K, Korca E, Stiller M, Szabó G, Simm A, Wächter K. 2023. Proteins Adsorbed during Intraoperative Hemoadsorption and Their In Vitro Effects on Endothelium. Healthcare. 19;11(3):310. doi: 10.3390/healthcare11030310. PMID: 36766885; PMCID: PMC9914797.

Mittag S, Wetzel F, Müller SY, Huber O. 2023. The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit. Cells. 12(3):353. doi: 10.3390/cells12030353. PMID: 36766695; PMCID: PMC9913352.

Hagenhaus V, Gorenflos López JL, Rosenstengel R, Neu C, Hackenberger CPR, Celik A, Weinert K, Nguyen MB, Bork K, Horstkorte R, Gesper A. 2023. Glycation Interferes with the Activity of the Bi-Functional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetyl-mannosamine Kinase (GNE). Biomolecules. 23;13(3):422. doi: 10.3390/biom13030422. PMID: 36979358; PMCID: PMC10046061.

Foronda H, Fu Y, Covarrubias-Pinto A, Bocker H. T, González A, Seemann E, Franzka P, Bock A, Bhaskara R. M, Liebmann L, Hoffmann M. E, Katona I, Koch N, Weis J, Kurth I, Gleeson J. G, Reggiori F, Hummer G, Kessels M. M, Qualmann B, Mari M, Dikić I, Hübner C. A. 2023. Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature, 618(7964), 402–410. https://doi.org/10.1038/s41586-023-06090-9.

Schildhauer P, Selke P, Scheller C, Strauss C, Horstkorte, R, Leisz S, Scheer, M. 2023. Glycation Leads to Increased Invasion of Glioblastoma Cells. Cells, 12(9), 1219. https://doi.org/10.3390/cells12091219.

Schindler M, Geisler SM, Seeling T, Navarrete Santos A. Ectopic Lipid Accumulation Correlates with Cellular Stress in Rabbit Blastocysts from Diabetic Mothers. 2023. Int J Mol Sci. 2023;24(14):11776. doi:10.3390/ijms241411776.

Philipp TM, Gernoth L, Will A, Schwarz M, Ohse VA, Kipp AP, Steinbrenner H, Klotz LO. 2023. Selenium-binding protein 1 (SELENBP1) is a copper-dependent thiol oxidase. Redox Biol. Jul 4;65:102807. doi: 10.1016/j.redox.2023.102807.

Jung M, Hartmann C, Ehrhardt T, Peter L. M, Abid C. L, Harwardt B, Hirschfeld J, Claus C, Haferkamp U, Pless O, Nastainczyk-Wulf M, Kehlen A, Schlote D, Schroder I. S, & Rujescu D. 2023. Generation of a set of induced pluripotent stem cell lines from two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and disease. Stem cell research, 69, 103072. https://doi.org/10.1016/j.scr.2023.103072.

Jung M, Jung JS, Pfeifer J, Hartmann C, Ehrhardt T, Abid CL, Kintzel J, Puls A, Navarrete Santos A, Hollemann T, Riemann D, Rujescu D. 2023. Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity. Mol Neurobiol. doi: 10.1007/s12035-023-03633-z.

Klotz LO, Carlberg C. 2023. Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics. Redox Biol. 68:102920. doi: 10.1016/j.redox.2023.102920. 

Philipp TM, Scheller AS, Krafczyk N, Klotz LO, Steinbrenner H. 2023. Methanethiol: A Scent Mark of Dysregulated Sulfur Metabolism in Cancer. Antioxidants (Basel). 12(9):1780. doi: 10.3390/antiox12091780. PMID: 37760083; PMCID: PMC10525899.

Doshi H, Spengler K, Godbole A, Gee YS, Baell J, Oakhill JS, Henke A, Heller R. 2023. AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1. Microbiol Spectr. 11(5):e0041723. doi: 10.1128/spectrum.00417-23.

Ceanga M, Rahmati V, Haselmann H, Schmidl L, Hunter D, Brauer AK, Liebscher S, Kreye J, Prüss H, Groc L, Hallermann S, Dalmau J, Ori A, Heckmann M, Geis C. 2023. Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony. Cell Rep. 42(10):113166. doi: 10.1016/j.celrep.2023.113166. 

Haferkamp U, Hartmann C, Abid CL, Brachner A, Höchner A, Gerhartl A, Harwardt B, Leckzik S, Leu J, Metzger M, Nastainczyk-Wulf M, Neuhaus W, Oerter S, Pless O, Rujescu D, Jung M, Appelt-Menzel A. Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease. Fluids Barriers CNS. 2023 Oct 31;20(1):78. doi: 10.1186/s12987-023-00471-y.

Trohl J, Schindler M, Buske M, de Nivelle J, Toto Nienguesso A, Navarrete Santos A. 2023. Advanced maternal age leads to changes within the insulin/IGF system and lipid metabolism in the reproductive tract and preimplantation embryo: insights from the rabbit model. Mol Hum Reprod. (12):gaad040. doi:10.1093/molehr/gaad040.

Kuldyushev N, Schönherr R, Coburger I, Ahmed M, Hussein RA, Wiesel E, Godbole A, Pfirrmann T, Hoshi T, Heinemann SH. 2022. A GFP-based ratiometric sensor for cellular methionine oxidation. Talanta. doi: 10.1016/j.talanta.2022.123332.

Ruhs S, Griesler B, Huebschmann R, Stroedecke K, Straetz N, Ihling C, Sinz A, Masch A, Schutkowski M, Gekle M, Grossmann C. 2022. Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 1. FASEB J. 36(1):e22059. doi: 10.1096/fj.202100977RR. PMID: 34847273.

Winterhalter PR, Simm A. 2022. How Justified is the Assumption of Programmed Aging in Reminiscence of Weismann's Theories? Biochemistry (Mosc). 87(1):35-53. doi: 10.1134/S0006297922010047.

Toma G, Lemnian IM, Karapetian E, Grosse I, Seliger B. 2022. Transcriptional Analysis of Total CD8+ T Cells and CD8+CD45RA- Memory T Cells From Young and Old Healthy Blood Donors. Front Immunol. doi: 10.3389/fimmu.2022.806906. PMID: 35154123.

Längrich T, Bork K, Horstkorte R, Weber V, Hofmann B, Fuszard M, Olzscha H. 2022. Disturbance of Key Cellular Subproteomes upon Propofol Treatment Is Associated with Increased Permeability of the Blood-Brain Barrier. Proteomes. doi: 10.3390/proteomes10030028.

Winterhalter PR, Wirkner M, Bartling B, Wächter K, Urazova A, Großkopf A, Diez C, Szabó G, Simm A. 2022. Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression. Mech Ageing Dev. 203:111635. doi: 10.1016/j.mad.2022.111635.

Barth M, Toto Nienguesso A, Navarrete Santos A, Schmidt C. 2022. Quantitative proteomics and in-cell cross-linking reveal cellular reorganisation during early neuronal differentiation of SH-SY5Y cells. Commun Biol. 7;5(1):551. doi: 10.1038/s42003-022-03478-7.

Hantel F, Liu H, Fechtner L, Neuhaus H, Ding J, Arlt D, Walentek P, Villavicencio-Lorini P, Gerhardt C, Hollemann T, Pfirrmann T. 2022. Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components. J Cell Sci. doi: 10.1242/jcs.259209.

Scheller AS, Philipp TM, Klotz LO, Steinbrenner H. 2022. Altered Capacity for H2S Production during the Spontaneous Differentiation of Caco-2 Cells to Colonocytes Due to Reciprocal Regulation of CBS and SELENBP1. Antioxidants (Basel). 11(10):1957. doi: 10.3390/antiox11101957.

Philipp TM, Gong W, Köhnlein K, Ohse VA, Müller FI, Priebs J, Steinbrenner H, Klotz LO. 2022. SEMO-1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro-aging factor conferring selective stress resistance. Biofactors. 48(3):699-706. doi: 10.1002/biof.1836.

Stabenow LK, Zibrova D, Ender C, Helbing DL, Spengler K, Marx C, Wang ZQ, Heller R. 2022. Oxidative Glucose Metabolism Promotes Senescence in Vascular Endothelial Cells. Cells. 16;11(14):2213. doi: 10.3390/cells11142213.

Franzka P, Turecki G, Cubillos S, Kentache T, Steiner J, Walter M, Hübner CA, Engmann O. 2022. Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12. Front. Nutr. 9:981511. doi: 10.3389/fnut.2022.981511.

Hussein RA, Ahmed M, Kuldyushev N, Schönherr R, Heinemann SH. 2022. Selenomethionine incorporation in proteins of individual mammalian cells determined with a genetically encoded fluorescent sensor. Free Radic Biol Med. 192:191-199. doi: 10.1016/j.freeradbiomed.2022.09.019.

Griesler B, Schuelke C, Uhlig C, Gadasheva Y, Grossmann C. 2022. Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity-When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood. Int J Mol Sci. 23(20):12592. doi: 10.3390/ijms232012592.

Toma G, Karapetian E, Massa C, Quandt D, Seliger B. 2022. Characterization of the effect of histone deacetylation inhibitors on CD8+ T cells in the context of aging. J Transl Med. 20(1):539. doi: 10.1186/s12967-022-03733-9.

Pfirrmann T, Gerhardt C. 2022. Life-Saver or Undertaker: The Relationship between Primary Cilia and Cell Death in Vertebrate Embryonic Development. J Dev Biol. 12;10(4):52. doi: 10.3390/jdb10040052. PMID: 36547474; PMCID: PMC9783631.

Wächter K, Gohde B, Szabó G, Simm A. 2022. Rye Bread Crust as an Inducer of Antioxidant Genes and Suppressor of NF-κB Pathway In Vivo. Nutrients. 12;14(22):4790. doi: 10.3390/nu14224790. PMID: 36432475; PMCID: PMC9697834.

Tauber S, Sieckmann MK, Erler K, Stahl W, Klotz LO, Steinbrenner H. 2021. Activation of Nrf2 by electrophiles is largely independent of the selenium status of HepG2 cells. Antioxidants (Basel) 23; 10: 167.doi: 10.3390/antiox10020167.

Hüttner SS, Hayn C, Ahrens HE, Schmidt M, Henze H, von Maltzahn J. 2021. Single myofiber culture assay for the assessment of adult muscle stem cell functionality ex vivo. J Vis Exp. 168. doi: 10.3791/62257.

Franzka P, Henze H, Jung MJ, Schüler SC, Mittag S, Biskup K, Liebmann L, Kentache T, Morales J, Martínez B, Katona I, Herrmann T, Huebner AK, Hennings JC, Groth S, Gresing LJ, Horstkorte R, Marquardt T, Weis J, Kaether C, Mutchinick OM, Ori A, Huber O, Blanchard V, von Maltzahn J, Hübner CA. 2021. GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation. J Clin Invest. 139076. doi: 10.1172/JCI139076.

Franzka P, Krüger L, Schurig M, Olecka M, Hoffmann S, Blanchard V, Hübner CA. 2021. Altered Glycosylation in the Aging Heart. Front. Mol. Biosci. doi.org/10.3389/fmolb.2021.673044.

Gadasheva Y, Nolze A, Großmann C. 2021. Posttranslational Modifications of the Mineralocorticoid Receptor and Cardiovascular Aging. Front Mol. Biosci. 8: 667990. doi: 10.3389/fmolb.2021.667990.

Fechtner L, Pfirrmann T. 2021. The GID ubiquitin ligase complex just reached the next level of complexity. Mol Cell. 81(11): 2270 - 2272. doi: 10.1016/j.molcel.2021.05.003.

Rühl P, Langner JM, Reidel J, Schönherr R, Hoshi T, Heinemann SH. 2021. Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators. Commun Biol 4, 1164. doi.org/10.1038/s42003-021-02675-0.

Di Sanzo S, Spengler K, Leheis A, Kirkpatrick JM, Rändler TL, Baldensperger T, Dau T, Henning C, Parca L, Marx C, Wang ZQ, Glomb MA, Ori A, Heller R. Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation. Nat Commun. 2021 Nov 18;12(1):6743. doi: 10.1038/s41467-021-26982-6

Fechtner L, Pfirrmann T. 2021. Ubiquitin ligases involved in progeroid syndromes and age-associated pathologies, Chapter in book: Proteostasis and Proteolysis. doi.org/10.1201/9781003048138

Pfirrmann T, Chondrogianni N, Olzscha H, Vasilaki A. 2021. Editorial: Dysregulated Protein Homeostasis in the Aging Organism. Front. Mol. Biosci. doi.org/10.3389/fmolb.2021.788118

Leonova T, Popova V, Tsarev A, Henning C, Antonova K, Rogovskaya N, Vikhnina M, Baldensperger T, Soboleva A, Dinastia E, Dorn M, Shiroglasova O, Grishina T, Balcke GU, Ihling C, Smolikova G, Medvedev S, Zhukov VA, Babakov V, Tikhonovich IA, Glomb MA, Bilova T, Frolov A. 2020. Does protein glycation impact on the drought-related changes in metabolism and nutritional properties of mature pea (Pisum sativum L.) seeds? Int J Mol Sci. 21. pii: E567. doi: 10.3390/ijms21020567.

Baldensperger T, Eggen M, Kappen J, Winterhalter PR, Pfirrmann T, Glomb MA. 2020. Comprehensive analysis of posttranslational protein modifications in aging of subcellular compartments. Sci Rep. 5;10(1):7596. doi: 10.1038/s41598-020-64265-0.

Köhnlein K, Urban N, Guerrero-Gómez D, Steinbrenner H, Urbánek P, Priebs J, Koch P, Kaether C, Miranda-Vizuete A, Klotz LO. 2020. A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity. Redox Biol. 28: 101323. doi: 10.1016/j.redox.2019.101323.

Grehl C, Wagner M, Lemnian IM, Glaser B, Grosse I. 2020. Performance of mapping approaches for whole-genome bisulfite sequencing data in crop plants. Front Plant Sci. 11: 176. doi: 10.3389/fpls.2020.00176.

Schindler M, Pendzialek SM, Grybel K, Seeling T, Navarrete Santos A. 2020. Metabolic profiling in blastocoel fluid and blood plasma of diabetic rabbits. Int J Mol Sci. 21(3): pii: E919. doi: 10.3390/ijms21030919.

Scheer M, Bork K, Simon F, Nagasundaram M, Horstkorte R, Gnanapragassam VS. 2020. Glycation leads to increased polysialylation and promotes the metastatic potential of neuroblastoma cells. Cells. 9. pii: E868. doi: 10.3390/cells9040868.

Weber V, Bork K, Horstkorte R, Olzscha H. 2020. Analyzing the permeability of the blood-brain barrier by microbial traversal through microvascular endothelial cells. J Vis Exp. 156. doi: 10.3791/60692.

Piskovatska V, Storey KB, Vaiserman AM, Lsuchak O. 2020. The use of metformin to increase the human healthspan. Adv Exp Med Biol. 1260: 319 - 332. doi: 10.1007/978-3-030-42667-5_13.

Tauber S, Steinbrenner H, Klotz LO. 2020. FoxO transcription factors in the control of redox homeostasis and fuel metabolism. Elsevier, Oxidative stress (edited by Helmut Sies) 17: 315 - 330. doi.org/10.1016/B978-0-12-818606-0.00017-1.

Burkuš J, Navarrete Santos A, Schindler M, Babeľová M, Jung JS, Špirková A, Kšiňanová M, Kovaříková M, Fischer B, Koppel J, Fabian D, Čikoš Š. 2020. Adiponectin stimulates glucose uptake in mouse blastocysts and embryonic carcinoma cells. Reproduction. 159: 227 - 239. doi: 10.1530/REP-19-0251.

Bähr I, Spielmann J, Quandt D, Kielstein H. Obesity-associated alterations of natural killer cells and immunosurveillance of cancer. 2020, Front Immunol. 11: 245. doi: 10.3389/fimmu.2020.00245.

De Nivelle J, Thoma J, Toto Nienguesso A, Jung JS, Seeling T, Navarrete Santos A, Schindler M. 2020. Rabbit as an aging model in reproduction: Advanced maternal age alters GLO1 expression in ovarian follicles and the endometrium at the time of implantation. Appl Sci. 10. 7732. doi.org/10.3390/app10217732.

Di Sanzo S, Spengler K, Leheis A, Kirkpatrick JM, Rändler TL, Baldensperger T, Parca L, Marx C, Qi Wang Z, Glomb MA, Ori A, Heller R. 2020. Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation. bioRxiv. doi.org/10.1101/2020.10.16.342311.

Korca E, Piskovatska V, Börgermann J, Navarrete Santos A, Simm A. 2020. Circulating antibodies against age-modified proteins in patients with coronary atherosclerosis. Sci Rep. 10: 17105. doi.org/10.1038/s41598-020-73877-5.

Kulka LAM, Fangmann PV, Panfilova D, Olzscha H. 2020. Impact of HDAC inhibitors on protein quality control systems: consequences for precision medicine in malignant disease. Front Cell Dev Biol. 8: 425. doi: 10.3389/fcell.2020.00425.

Rosenstock P, Bork K, Massa C, Selke P, Seliger B, Horstkorte R. 2020. Sialylation of human natural killer (NK) cells is regulated by IL-2. J Clin Med. 9: 1816. doi: 10.3390/jcm9061816.

Schindler M, Dannenberger D, Nuernberg G, Pendzialek M, Grybel K, Seeling T, Santos AN. 2020. Embryonic fatty acid metabolism in diabetic pregnancy: the difference between embryoblasts and trophoblasts. Mol Hum Reprod. 26. 837-849. doi: 10.1093/molehr/gaaa063.

Fuellen G, Liesenfeld O, Kowald A, Barrantes I, Bastian M, Simm A, Jansen L, Tietz-Latza A, Quandt D, Franceschi C, Walter M. 2020. The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging). Ageing Res Rev. 62: 101091. doi: 10.1016/j.arr.2020.101091.

Weber V, Olzscha H, Längrich T, Hartmann C, Jung M, Hofmann B, Horstkorte R, Bork K. 2020. Glycation increases the risk of microbial traversal through an endothelial model of the human blood-brain barrier after use of anesthetics. J. Clin. Med. 9(11): 3672. doi.org/10.3390/jcm9113672.

Baldensperger T, Di Sanzo S, Ori A, Glomb MA. 2019. Quantitation of reactive acyl-CoA species mediated protein acylation by HPLC–MS/MS. Anal Chem. 91: 12336 - 12343. doi: 10.1021/acs.analchem.9b02656.

Simon F, Bork K, Gnanapragassam VS, Baldensperger T, Glomb MA, Di Sanzo S, Ori A, Horstkorte R. 2019. Increased expression of immature mannose-containing glycoproteins and sialic acid in aged mouse brains. Int J Mol. Sci. 20. pii:E6118. doi: 10.3390/ijms20246118.

Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, Franzka P, von Kleist L, Stauber T, Klumperman J, Damme M, Proikas-Cezanne T, Hübner CA. 2019. A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five. Neurobiol Dis. 127: 419 - 431. doi: 10.1016/j.nbd.2019.03.026.

Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T. 2019. The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. Autophagy Dec 3: 1 - 17. doi: 10.1080/15548627.2019.1695399.

Cavalli M, Baltzer N, Umer HM, Grau J, Lemnian I, Pan G, Wallerman O, Spalinskas R, Sahlén P, Grosse I, Komorowski J, Wadelius C. 2019. Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases. Sci Rep. 9: 2695. doi: 10.1038/s41598-019-39633-0.

Liu H, Pfirrmann T. 2019. The Gid-complex: an emerging player in the ubiquitin ligase league. Biol Chem. 400: 1429 - 1441. doi: 10.1515/hsz-2019-0139.

Bezold V, Rosenstock P, Scheffler J, Geyer H, Horstkorte R, Bork K. 2019. Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency. Aging (Albany NY). 11: 5258 - 5275. doi: 10.18632/aging.102123.

Franka F, Bezold V, Bork K, Rosenstock P, Scheffler J, Horstkorte R. 2019. Advanced glycation end products and polysialylation affect the turnover of the neural cell adhesion molecule (NCAM) and the receptor for advanced glycation endproducts (RAGE). Biol Chem. 400: 219 - 226. doi: 10.1515/hsz-2018-0291.

Rosenstock P, Bezold V, Bork K, Scheffler J, Horstkorte R. 2019. Glycation interferes with natural killer cell function. Mech Ageing Dev. 178: 64 - 71. doi: 10.1016/j.mad.2019.01.006.

Scheffler J, Bork K, Bezold V, Rosenstock P, Gnanapragassam VS, Horstkorte R. 2019. Ascorbic acid leads to glycation and interferes with neurite outgrowth. Exp Gerontol. 117: 25 - 30. doi: 10.1016/j.exger.2018.08.005.

Seeling T, Haucke E, Navarrete Santos A, Grybel KJ, Gürke J, Pendzialek MS, Schindler M, Simm A, Navarrete Santos A. 2019. Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits. Reprod Domest Anim. 54 Suppl 3: 4 - 11. doi: 10.1111/rda.13462.

Wickenhauser C, Bethmann D, Feng Z, Jensen SM, Ballesteros-Merino C, Massa C, Steven A, Bauer M, Kaatzsch P, Pazaitis N, Toma G, Bifulco CB, Fox BA, Seliger B. 2019. Multispectral fluorescence imaging allows for distinctive topographic assessment and subclassification of tumor-infiltrating and surrounding immune cells. Methods Mol Biol. 1913: 13 - 31. doi: 10.1007/978-1-4939-8979-9_2.

Ye Z, Yuan F, Liu JQ, Peng XR, An T, Li X, Kong LM, Qiu MH, Li Y. 2019. Physalis peruviana-derived 4b-hydroxywithanolide E, a novel antagonist of Wnt signaling, inhibits colorectal cancer in vitro and in vivo. Molecules. 24. pii: E1146. doi: 10.3390/moleculaes24061146.

Ye Z, Mittag S, Schmidt M, Simm A, Horstkorte R, Huber O. 2019. Wnt glycation inhibits canonical signaling. Cells 8. pii: E1320. doi: 10.3390/cells811320.

Stabenow LK. 2019 Aortic pseudoaneurysms. In: Dieter R, Dieter Jr R, Dieter III R (eds). Diseases of the aorta. Springer, Cham. doi.org/10.1007/978-3-030-11322-3_37.

Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita Y, Rudolph KL. 2019. Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation. J Exp Med. 216: 152 - 175. doi: 10.1084/jem.20181505.

Kelmer Sacramento E, Kirkpatrick JM, Mazzetto M, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Bartolome A, Romanov N, Baumgart M, Huber W, Chondrogianni N, Vendruscolo M, Cellerino A, Ori A. 2019. Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation. Mol Syst Biol. 16(6) doi.org/10.15252/msb.20209596

Graber K, Khan F, Glück B, Weigel C, Marzo S, Doshi H, Ehrhardt C, Heller R, Gräler M, Henke A. 2019. The role of sphingosine-1-phosphate signaling in HSV-1-infected human umbilical vein endothelial cells. Virus Res. 276: 197835. doi: 10.1016/j.virusres.2019.197835.

Yang K, Coburger I, Langner JM, Peter N, Hoshi T, Schönherr R, Heinemann SH. 2019. Modulation of K+ channel N-type inactivation by sulfhydration through hydrogen sulphide and polysulfides. Pflugers Arch. 471: 557 - 571. doi: 10.1007/s00424-018-2233-x.

Piskovatska V, Strilbytska O, Koliada A, Vaiserman A, Lushchak O. 2019. Health benefits of anti-aging drugs, Chapter in book: Biochemistry and Cell Biology of Ageing: Part II Clinical Science. doi:10.1007/978-981-13-3681-2_13.

Gille A, Turkistani A, Tsitsipatis D, Hou X, Tauber S, Hamann I, Urban N, Erler K, Steinbrenner H, Klotz LO. 2019. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 20: 19 - 27. doi: 10.1016/j.redox.2018.09.010.

Jung JS, Volk C, Marga C, Navarrete Santos A, Jung M, Rujescu D, Navarrete Santos A. 2019. Adipose-derived stem/stromal cells (ASCs) recapitulate aging biomarkers and show reduced stem cell plasticity affecting their adipogenic differentiation capacity. Cell Reprogram. 21: 187 - 199. doi:10.1089/cell.2019.0010.

Janke S, Mittag S, Reiche J, Huber O. 2019. Apoptotic fragmentation of tricellulin. Int J Mol Sci. 20. pii: E4882. doi: 10.3390/ijms20194882.

Kraya T+, Quandt D+, Pfirrmann T, Kindermann A, Lampe L, Schroeter ML, Kohlhase J, Stoevesandt D, Hoffmann K, Villavicencio-Lorini P. 2019. Functional characterization of a novel CSF1R mutation causing hereditary diffuse leukoencephalopathy with spheroids. Mol Genet Genomic Med. 7: e00595. doi: 10.1002/mgg3.595. +shared first authorship.

Rousseau-Ralliard D, Couturier-Tarrade A, Thieme R, Brat R, Rolland A, Boileau P, Aubrière M-C, Daniel N, Dahirel M, Derisoud E, Fournier N, Schindler M, Duranthon V, Fischer B, Navarrete Santos A, Chavatte-Palmer P. 2019. A short periconceptional exposure to maternal type-1 diabetes is sufficient to disrupt the feto-placental phenotype in a rabbit model. Mol Cell Endocrinol. 480: 42 - 53. doi: 10.1016/j.mce.2018.10.010.

Cherkas A, Mondol AS, Rüger J, Urban N, Popp J, Klotz LO, Schie IW. 2019. Label-free molecular mapping and assessment of glycogen in C. elegans. Analyst 144: 2367 - 2374. doi: 10.1039/c8an02351d.

Hemling P, Zibrova D, Strutz J, Sohrabi Y, Desoye G, Schulten H, Findeisen H, Heller R, Godfrey R, Waltenberger J. 2019. Hyperglycemia-induced endothelial dysfunction is alleviated by thioredoxin mimetic peptides through the restoration of VEGFR-2-induced responses and improved cell survival. Int J Cardiol. pii: S0167 - 5273. doi: 10.1016/j.ijcard.2019.12.065.

Klaus A, Baldensperger T, Fiedler R, Girndt M, Glomb MA. 2018. Influence of transketolase-catalyzed reactions on the formation of glycolaldehyde and glyoxal specific posttranslational modifications under physiological conditions. J Agric Food Chem. 66: 1498 - 1508. doi: 10.1021/acs.jafc.7b05472.

Baldensperger T, Jost T, Zipprich A, Glomb MA. 2018. Novel α-oxoamide advanced-glycation endproducts within the N6-carboxymethyl lysine and N6-carboxyethyl lysine reaction cascades. J Agric Food Chem. 66: 1898 - 1906. doi: 10.1021/acs.jafc.7b05813.

Kuldyushev NA, Mineev KS, Berkut AA, Peigneur S, Arseniev AS, Tytgat J, Grishin EV, Vassilevski AA. 2018. Refined structure of BeM9 reveals arginine hand, an overlooked structural motif in scorpion toxins affecting sodium channels. Proteins 86: 1117 - 1122. doi: 10.1002/prot.25583.

Hedtke I, Lemnian I, Grosse I, Müller-Hannemann M. 2018. Optimal block-based trimming for next generation sequencing. IEEE/ACM Trans Comput Biol Bioinform. 15: 364 - 376. doi: 10.1109/TCBB.2017.2696525.

Mehlgarten C, Eggeling R, Gohr A, Bönn M, Lemnian I, Nettling M, Strödecke K, Kleindienst C, Grosse I, Breunig KD. 2018. Evolution of the AMP-activated protein kinase controlled gene regulatory network. In: Bossert M. (eds) Information- and Communication Theory in Molecular Biology.  Lecture Notes in Bioengineering. Springer, Cham. ISBN 978-3-319-54729-9. doi.org/10.1007/978-3-319-54729-9_9.

Oswald J, Büttner M, Jasinski-Bergner S, Jacobs R, Rosenstock P, Kielstein H. 2018. Leptin affects filopodia and cofilin in NK-92 cells in a dose- and time-dependent manner. Eur J Histochem 62(1): 2848. doi: 10.4081/ejh.2018.2848.

Seeling T, Čikoš Š, Grybel KJ, Janštová Ž, Pendzialek SM, Schindler M, Špirková A, Santos AN. 2018. A diabetic pregnancy alters the expression of stress-related receptors in gastrulating rabbit blastocyst and in the reproductive tract. Reprod Sci. 25: 174 - 184. doi: 10.1177/1933719117707055.

Stabenow L, Byers M, Malik A, Ali F. 2018. Endovascular repair of pseudoaneurysm adjacent to the ascending thoracic aorta using a 25mm Amplatzer® Cribriform Septal Occluder. Vasc Dis Manag. 15: E39 - E41.

Piskovatska V, Stefanyshyn N, Storey KB, Vaiserman AM, Lushchak O. 2018. Metformin as a geroprotector: experimental and clinical evidence. Biogerontology. 20: 33 - 48. doi: 10.1007/s10522-018-9773-5.

Lushchak O, Strilbytska O, Piskovatska V, Koliada A, Storey KB. 2018. Intermittent fasting, Chapter in book: Reference Module in Biomedical Sciences. 2018. doi:10.1016/B978-0-12-801238-3.62133-5.

Piskovatska V, Strilbytska O, Storey KB, Vaiserman A, Lushchak O. 2018. mTOR pharmacology, Chapter in book: Reference Module in Biomedical Sciences. doi:10.1016/B978-0-12-801238-3.62134-7.

Grünberg M*, Quandt D*, Cynis H, Demuth HU, Kindermann A., Magdolen V, Forssmann WG, Seliger B, Mägert HJ. 2018. Kallikrein-related peptidases are activators of the CC chemokine CCL14. Eur J Immunol. 48 : 1592 - 1594. doi: 10.1002/eji.201747452. *shared first authorship.

Gold WA, Sobreira N, Wiame E, Marbaix A, Van Schaftingen E, Franzka P, Riley LG, Worgan L, Hübner CA, Christodoulou J, Adès LC. 2017. A novel mutation in GMPPA in sibling with apparent intellectual disability, epilepsy, dysmorphism, and autonomic dysfunction. Am J Med Genet A. 173: 2246 - 2250. doi: 10.1002/ajmg.a.38292.

Ruhs S, Nolze A, Hübschmann R, Grossmann C. 2017. 30 years of the mineralocorticoid receptor: Nongenomic effects via the mineralocorticoid receptor. J Endocrinol. 234: T107 -T124. doi: 10.1530/JOE-16-0659.

Kuldyushev NA, Berkut AA, Peigneur S, Tytgat J, Grishin EV, Vassilevski AA. 2017. Design of sodium channel ligands with defined selectivity – a case study in scorpion alpha-toxins. FEBS Letters 591: 3414 - 3420. doi: 10.1002/1873-3468.12839.

Ding J, Shao L, Yao Y, Tong X, Liu H, Yue S, Xie L, Cheng SY. 2017. DGKd triggers endoplasmic reticulum release of IFT-88-containing vesicles destined for the assembly of primary cilia. Sci Rep. 7: 5296. doi: 10.1038/s41598-017-05680-8.

Liu H, Yan S, Ding J, Yu TT, Cheng SY. 2017. DeSUMOylation of Gli1 by SENP1 attenuates sonic hedgehog signaling. Mol Cell Biol. 37. pii: e00579-16. doi: 10.1128/MCB.00579-16.

Bähr I, Goritz V, Doberstein H, Hiller GG, Rosenstock P, Jahn J, Pörtner O, Berreis T, Mueller T, Spielmann J, Kielstein H. 2017. Diet-induced obesity is associated with an impaired NK cell function and an increased colon cancer incidence. J Nutr Metab. 2017:4297025. doi: 10.1155/2017/4297025.

Rosenstock P, Horstkorte R, Gnanapragassam VS, Harth J, Kielstein H. 2017. Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans. Immunol Res. 65: 1017 - 1024. doi: 10.1007/s12026-017-8942-y.

Schindler M, Pendzialek M, Grybel KJ, Seeling T, Gürke J, Fischer B, Navarrete Santos A. 2017. Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts. Hum Reprod. 32: 1382 - 1392. doi: 10.1093/humrep/dex087.

Dong X, Zhang J, Zhou Z, Ye Z, Chen J, Yuan J, Cao F, Wang X, Liu W, Yu W, Li X. 2017. Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat pheochromocytoma PC12 cells. Oncotarget. 8: 74527 - 7453. doi: 10.18632/oncotarget.20210.

Hohmann C, Liehr K, Henning C, Fiedler R, Girndt M, Gebert M, Hulko M, Storr M, Glomb MA. 2017. Detection of free advanced glycation end products in vivo during hemodialysis. J Agric Food Chem. 65: 930 - 937. doi: 10.1021/acs.jafc.6b05013.

Lushchak O, Strilbytska O, Piskovatska V, Storey KB, Koliada A, Vaiserman A. 2017. The role of the TOR pathway in mediating the link between nutrition and longevity. Mech Ageing Dev. 164: 127 - 138. doi: 10.1016/j.mad.2017.03.005.

Bork K, Weidemann W, Berneck B, Kuchta M, Bennmann D, Thate A, Huber O, Gnanapragassam VS, Horstkorte R. 2017. The expression of sialyltransferases is regulated by the bioavailability and biosynthesis of sialic acids. Gene Expr Patterns. 23 - 24: 52 - 58. doi: 10.1016/j.gep.2017.03.003.

Kreuzmann D, Horstkorte R, Kohla G, Kannicht C, Bennmann D, Thate A, Bork K. 2017. Increased polysialylation of the neural cell adhesion molecule in a transgenic mouse model of sialuria. Chembiochem. 18: 1188 - 1193. doi: 10.1002/cbic.201600580.

Jennek S, Mittag S, Reiche J, Westphal JK, Seelk S, Dörfel MJ, Pfirrmann T, Friedrich K, Schütz A, Heinemann U, Huber O. 2017. Tricellulin is a target of the ubiquitin ligase Itch. Ann N Y Acad Sci. 1397: 157 - 168. doi: 10.1111/nyas.13349.

Wetzel F, Mittag S, Cano-Cortina M, Wagner T, Krämer OH, Niedenthal R, Gonzalez-Mariscal L, Huber O. 2017. SUMOylation regulates the intracellular fate of ZO-2. Cell Mol Life Sci. 74: 373 - 392. doi: 10.1007/s00018-016-2352-5.

Jasinski-Bergner S, Büttner M, Quandt D, Seliger B, Kielstein H. 2017. Adiponectin and its receptors are differentially expressed in human tissues and cell lines of distinct origin. Obesity Facts. 10: 569 - 583. doi: 10.1159/000481732.

Quandt D, Fiedler E, Müller A, Marsch WC, Seliger B. 2017. High constitutive B7-H3 expression on human keratinocytes supports T cell immunity. J Dermatol Sci. 87: 82 - 85. doi: 10.1016/j.jdermsci.2017.02.287.

Rothe K, Raulien N, Pierer M, Quandt D*, Wagner U*. 2017. Autoimmune arthritis induces paired immunoglobulin-like receptor B expression on CD4+ T cells from SKG mice. Eur J Immunol. 47: 1457 - 1467. doi: 10.1002/eji.201646747. *shared last authorship

Ruhs S, Strätz N, Quarch K, Masch A, Schutkowski M, Gekle M, Grossmann C. 2017. Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2. Sci Rep. 7: 15340. doi: 10.1038/s41598-017-15418-1.

Fischer B, Schindler M, Mareike Pendzialek S, Gürke J, Haucke E, Grybel KJ, Thieme R, Navarrete Santos A. 2017. The long-term effect of the periconception period on the embryo's epigenetic profile and phenotype: The role of maternal disease such as diabetes and how the effect is mediated (example from a rabbit model). Adv Exp Med Biol. 1014: 107 - 115. doi: 10.1007/978-3-319-62414-3_6.

Pendzialek SM, Schindler M, Plösch T, Gürke J, Haucke E, Hecht S, Fischer B, Navarrete Santos A. 2017. Cholesterol metabolism in rabbit blastocysts under maternal diabetes. Reprod Fertil Dev. 29: 1921 - 1931. doi: 10.1071/RD15542.

Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO. 2017. Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol. 11: 502 - 515. doi: 10.1016/j.redox.2016.12.003.

Bär L, Wächter K, Wege N, Navarrete Santos A, Simm A, Föller M. 2017. Advanced glycation end products stimulate gene expression of fibroblast growth factor 23. Mol Nutr Food Res. 61. doi: 10.1002/mnfr.201601019.

Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R. 2017. GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. Biochem J. 474: 983 - 1001. This article has a commentary by Scott JW, Oakhill JS. 2017. The sweet side of AMPK signaling: regulation of GFAT1. Biochem J. 474: 1289 - 1292. doi: 10.1042/BCJ20160980.