AG Stammzellforschung und Molekulare Kardiologie

2024

Lädrach C, Wartenberg M, Zimmerli S, Anschuetz L, Bohlen S, Ebner J, de
Gouyon Matignon de Pontouraude CMF, Caversaccio M, Wagner F. Survival from
Rhino-Orbital-Cerebral Mucormycosis in SARS-CoV-2-Positive Diabetic Patients:
Two Case Reports. Case Rep Neurol. 2024 Apr 2;16(1):89-98. doi:
10.1159/000538539. PMID: 38690082; PMCID: PMC11057842.

Aicher ML, Bisch-Karatas J, Maurer A, Wagner F, Wartenberg M, Zimmerli S.
Rare case of a chronic rhinocerebral mucormycosis. Med Mycol Case Rep. 2024 Apr
9;44:100648. doi: 10.1016/j.mmcr.2024.100648. PMID: 38654745; PMCID:
PMC11035103.

2023

Sampaio P, Lopez-Antuña M, Storni F, Wicht J, Sökeland G, Wartenberg M,
Márquez-Neila P, Candinas D, Demory BO, Perren A, Sznitman R. Müller matrix
polarimetry for pancreatic tissue characterization. Sci Rep. 2023 Sep
29;13(1):16417. doi: 10.1038/s41598-023-43195-7. PMID: 37775538; PMCID:
PMC10541901.

Xiang-Tischhauser L, Bette M, Rusche JR, Roth K, Kasahara N, Stuck BA,
Bakowsky U, Wartenberg M, Sauer H, Geisthoff UW, Mandic R. Generation of a
Syngeneic Heterozygous <i>ACVRL1(wt/mut)</i> Knockout iPS Cell Line for the In
Vitro Study of HHT2-Associated Angiogenesis. Cells. 2023 Jun 10;12(12):1600.
doi: 10.3390/cells12121600. PMID: 37371070; PMCID: PMC10297623.

Scharmacher J, Wartenberg M, Sauer H. The pro-inflammatory signature of
lipopolysaccharide in spontaneous contracting embryoid bodies differentiated
from mouse embryonic stem cells. J Cell Mol Med. 2023 Jul;27(14):2045-2058. doi:
10.1111/jcmm.17805. Epub 2023 Jun 14. PMID: 37315183; PMCID: PMC10339090.

Wartenberg M, Hool SL, Marrazzini A, Giger R, Rupp NJ. Differentiated
Papillary NUT Carcinoma: An Unexpected, Deceptively Bland Presentation of a
Sinonasal Carcinoma. Head Neck Pathol. 2023 Sep;17(3):803-807. doi:
10.1007/s12105-023-01554-w. Epub 2023 Apr 28. PMID: 37118352; PMCID:
PMC10513967.

Bräutigam K, Reinhard S, Wartenberg M, Forster S, Greif K, Granai M,
Bösmüller H, Klingel K, Schürch CM. Comprehensive analysis of SARS-CoV-2
receptor proteins in human respiratory tissues identifies alveolar macrophages
as potential virus entry site. Histopathology. 2023 May;82(6):846-859. doi:
10.1111/his.14871. Epub 2023 Feb 21. PMID: 36700825.

Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari
N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván
JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schürch CM, Puri PL,
Bruneau BG, Hargreaves DC, Reya T. Smarcd3 is an epigenetic modulator of the
metabolic landscape in pancreatic ductal adenocarcinoma. Nat Commun. 2023 Jan
18;14(1):292. doi: 10.1038/s41467-023-35796-7. PMID: 36653361; PMCID:
PMC9849267.

2022

Husson O, Drabbe C, Schuster K, van Kampen P, Koops C, Weidema M, Davidson R,
Wartenberg M, Artzner E, Gonzato O, Fernandez N, Kasper B, Pilgermann K, Wilson
R, van der Graaf WTA, van Oortmerssen G. Setting the international research
agenda for sarcoma together with patients and carers: first results of the
Sarcoma Patient EuroNet (SPAEN) priority setting partnership. ESMO Open. 2022
Jun;7(3):100509. doi: 10.1016/j.esmoop.2022.100509. Epub 2022 Jun 14. PMID:
35714479; PMCID: PMC9271500.

Khosravi F, Ahmadvand N, Wartenberg M, Sauer H. Induction of Stem-Cell-
Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its
Interplay with Cardiotrophin-1 (CT-1). Biology (Basel). 2022 Mar 30;11(4):534.
doi: 10.3390/biology11040534. PMID: 35453733; PMCID: PMC9026462.

Engelhardt S, Dislich B, Zubler C, Maragkou T, Wartenberg M, Tzankov A.
Myositis als postakute Folge einer COVID-19-Erkrankung? : Auch in Zeiten der
Pandemie können Muskelbiopsien oft nur im Kontext einer genauen Weitergabe
klinischer Informationen beurteilt werden [Myositis as a post-acute sequela of
COVID-19 disease? : Even in times of the pandemic, muscle biopsies can only be
assessed in the context of accurate clinical information]. Pathologie (Heidelb).
2022 Sep;43(5):377-380. German. doi: 10.1007/s00292-022-01063-7. Epub 2022 Apr
4. PMID: 35376988; PMCID: PMC8978168.

Kasper B, Schuster K, Wilson R, Bickley S, Blay JY, Reinke D, Wartenberg M,
Haas R. Global Patient Involvement in Sarcoma Care-A Collaborative Initiative of
the Connective Tissue Oncology Society (CTOS) & Sarcoma Patients EuroNet
(SPAEN). Cancers (Basel). 2022 Feb 9;14(4):854. doi: 10.3390/cancers14040854.
PMID: 35205602; PMCID: PMC8870105.

Bräutigam K, Reinhard S, Galván JA, Wartenberg M, Hewer E, Schürch CM.
Systematic Investigation of SARS-CoV-2 Receptor Protein Distribution along Viral
Entry Routes in Humans. Respiration. 2022;101(6):610-618. doi:
10.1159/000521317. Epub 2022 Jan 17. PMID: 35038715; PMCID: PMC8805044.

2021

Saidi A, Wartenberg M, Madinier JB, Ilango G, Seren S, Korkmaz B, Lecaille
F, Aucagne V, Lalmanach G. Monitoring Human Neutrophil Activation by a
Proteinase 3 Near-Infrared Fluorescence Substrate-Based Probe. Bioconjug Chem.
2021 Aug 18;32(8):1782-1790. doi: 10.1021/acs.bioconjchem.1c00267. Epub 2021 Jul
16. PMID: 34269060.

Blay JY, Casali P, Bouvier C, Dehais C, Galloway I, Gietema J, Halámková J,
Hindi N, Idbaih A, Kinloch E, Klümpen HJ, Kolarova T, Kopeckova K, Lovey J,
Magalhaes M, Oselin K, Piperno-Neumann S, Ravnsbaek A, Rogasik M, Safwat A,
Scheipl S, Seckl M, Taylor J, Temnyk M, Trama A, Urbonas M, Wartenberg M,
Weinman A; EURACAN Network. European Reference Network for rare adult solid
cancers, statement and integration to health care systems of member states: a
position paper of the ERN EURACAN. ESMO Open. 2021 Aug;6(4):100174. doi:
10.1016/j.esmoop.2021.100174. Epub 2021 Jun 15. PMID: 34139485; PMCID:
PMC8219752.

Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A,
Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY,
Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava
E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V,
Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F,
Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H,
Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A,
Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir
O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S,
Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski
P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P,
Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf
WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M,
Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A. Epithelioid
hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community
of experts. ESMO Open. 2021 Jun;6(3):100170. doi: 10.1016/j.esmoop.2021.100170.
Epub 2021 Jun 2. PMID: 34090171; PMCID: PMC8182432.

Eichler M, Andreou D, Golcher H, Hentschel L, Richter S, Hohenberger P,
Kasper B, Pink D, Jakob J, Ashmawy H, Hettmer S, Tuchscherer A, Grube M, Heidt
V, Jentsch C, Pablik J, Wardelmann E, Kreitner KF, Kneser U, Tonus C, Wimberger
P, Schoffer O, Reichardt P, Wartenberg M, Eberlein-Gonska M, Bornhäuser M,
Schmitt J, Schuler MK. Utilization of Interdisciplinary Tumor Boards for Sarcoma
Care in Germany: Results from the PROSa Study. Oncol Res Treat.
2021;44(6):301-312. doi: 10.1159/000516262. Epub 2021 Apr 22. PMID: 33887740;
PMCID: PMC8220922.

Freiberger SN, Brada M, Fritz C, Höller S, Vogetseder A, Horcic M, Bihl M,
Michal M, Lanzer M, Wartenberg M, Borner U, Bode PK, Broglie MA, Rordorf T,
Morand GB, Rupp NJ. SalvGlandDx - a comprehensive salivary gland neoplasm
specific next generation sequencing panel to facilitate diagnosis and identify
therapeutic targets. Neoplasia. 2021 May;23(5):473-487. doi:
10.1016/j.neo.2021.03.008. Epub 2021 Apr 18. PMID: 33878706; PMCID: PMC8081865.

Bekhite M, González-Delgado A, Hübner S, Haxhikadrija P, Kretzschmar T,
Müller T, Wu JMF, Bekfani T, Franz M, Wartenberg M, Gräler M, Greber B, Schulze
PC. The role of ceramide accumulation in human induced pluripotent stem cell-
derived cardiomyocytes on mitochondrial oxidative stress and mitophagy. Free
Radic Biol Med. 2021 May 1;167:66-80. doi: 10.1016/j.freeradbiomed.2021.02.016.
Epub 2021 Mar 9. PMID: 33705961.

Sheppard SC, Borner U, Wartenberg M, Giger R, Nisa L. Diagnostic use of
fine-needle aspiration cytology and core-needle biopsy in head and neck
sarcomas. Head Neck. 2021 Jun;43(6):1939-1948. doi: 10.1002/hed.26670. Epub 2021
Mar 9. PMID: 33687108.

Sauer H, Kampmann H, Khosravi F, Sharifpanah F, Wartenberg M. The
nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of
prostate tumour spheroids and increases doxorubicin retention without changes in
drug transporter and cancer stem cell protein expression. Clin Exp Pharmacol
Physiol. 2021 Mar;48(3):422-434. doi: 10.1111/1440-1681.13452. Epub 2020 Dec 21.
PMID: 33349973.

2020

Karamitopoulou E, Esposito I, Zlobec I, Insilla AC, Wartenberg M, Schaeffer
DF, Kalloger S, La Rosa S, Sempoux C, Ramos Centeno I, Lohneis P.
Reproducibility of tumor budding assessment in pancreatic cancer based on a
multicenter interobserver study. Virchows Arch. 2021 Apr;478(4):719-726. doi:
10.1007/s00428-020-02987-2. Epub 2020 Dec 17. PMID: 33330964; PMCID: PMC7990816.

Laros N, Sungu-Winkler KT, Gutermuth S, Wartenberg M, Hohenberger P, Seifart
U, Kasper B. Career and Financial Situation of Patients Diagnosed with Soft
Tissue Sarcomas. Oncol Res Treat. 2020;43(10):539-548. doi: 10.1159/000509518.
Epub 2020 Sep 16. PMID: 32937624.

Möhner DM, Bernhardt A, Bekhite MM, Schulze PC, Sauer H, Wartenberg M.
Zoxazolamine-induced stimulation of cardiomyogenesis from embryonic stem cells
is mediated by Ca²⁺, nitric oxide and ATP release. Biochim Biophys
Acta Mol Cell Res. 2020 Nov;1867(11):118796. doi: 10.1016/j.bbamcr.2020.118796.
Epub 2020 Jul 11. PMID: 32663504.

Bekhite MM, González Delgado A, Menz F, Kretzschmar T, Wu JMF, Bekfani T,
Nietzsche S, Wartenberg M, Westermann M, Greber B, Schulze PC. Longitudinal
metabolic profiling of cardiomyocytes derived from human-induced pluripotent
stem cells. Basic Res Cardiol. 2020 May 18;115(4):37. doi:
10.1007/s00395-020-0796-0. PMID: 32424548.

Lalmanach G, Saidi A, Bigot P, Chazeirat T, Lecaille F, Wartenberg M.
Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants. Int J
Mol Sci. 2020 Mar 12;21(6):1944. doi: 10.3390/ijms21061944. PMID: 32178437;
PMCID: PMC7139492.

Wartenberg M, Andrault PM, Saidi A, Bigot P, Nadal-Desbarats L, Lecaille F,
Lalmanach G. Oxidation of cathepsin S by major chemicals of cigarette smoke.
Free Radic Biol Med. 2020 Apr;150:53-65. doi:
10.1016/j.freeradbiomed.2020.02.013. Epub 2020 Feb 19. PMID: 32084513.

Taha A, Sharifpanah F, Wartenberg M, Sauer H. Omega-3 and Omega-6
polyunsaturated fatty acids stimulate vascular differentiation of mouse
embryonic stem cells. J Cell Physiol. 2020 Oct;235(10):7094-7106. doi:
10.1002/jcp.29606. Epub 2020 Feb 5. PMID: 32020589.

Desmoid Tumor Working Group. The management of desmoid tumours: A joint
global consensus-based guideline approach for adult and paediatric patients. Eur
J Cancer. 2020 Mar;127:96-107. doi: 10.1016/j.ejca.2019.11.013. Epub 2020 Jan
28. PMID: 32004793.

2019

Stickel F, Wartenberg M, Bouzourene H, Ortner MA, Rogler G. Recurrent Fever
and Failure to Thrive in an 11-Year-Old Boy. Case Rep Gastroenterol. 2019 Aug
29;13(2):350-356. doi: 10.1159/000502604. PMID: 31607835; PMCID: PMC6787408.

Andrault PM, Schamberger AC, Chazeirat T, Sizaret D, Renault J, Staab-
Weijnitz CA, Hennen E, Petit-Courty A, Wartenberg M, Saidi A, Baranek T,
Guyetant S, Courty Y, Eickelberg O, Lalmanach G, Lecaille F. Cigarette smoke
induces overexpression of active human cathepsin S in lungs from current smokers
with or without COPD. Am J Physiol Lung Cell Mol Physiol. 2019 Nov
1;317(5):L625-L638. doi: 10.1152/ajplung.00061.2019. Epub 2019 Sep 25. PMID:
31553637.

Patel NA, Li G, Shang W, Wartenberg M, Heffter T, Burdette EC, Iordachita I,
Tokuda J, Hata N, Tempany CM, Fischer GS. System Integration and Preliminary
Clinical Evaluation of a Robotic System for MRI-Guided Transperineal Prostate
Biopsy. J Med Robot Res. 2019 Jun;4(2):1950001. doi: 10.1142/S2424905X19500016.
Epub 2018 May 15. PMID: 31485544; PMCID: PMC6726403.

Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch
CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M,
Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French
R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H,
Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T. A Multiscale Map of the Stem
Cell State in Pancreatic Adenocarcinoma. Cell. 2019 Apr 18;177(3):572-586.e22.
doi: 10.1016/j.cell.2019.03.010. Epub 2019 Apr 4. PMID: 30955884; PMCID:
PMC6711371.

Wartenberg M, Saidi A, Galibert M, Joulin-Giet A, Burlaud-Gaillard J,
Lecaille F, Scott CJ, Aucagne V, Delmas AF, Lalmanach G. Imaging of
extracellular cathepsin S activity by a selective near infrared fluorescence
substrate-based probe. Biochimie. 2019 Nov;166:84-93. doi:
10.1016/j.biochi.2019.03.013. Epub 2019 Mar 23. PMID: 30914255.

Saidi A, Kasabova M, Vanderlynden L, Wartenberg M, Kara-Ali GH, Marc D,
Lecaille F, Lalmanach G. Curcumin inhibits the TGF-β1-dependent differentiation
of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L. Sci
Rep. 2019 Jan 24;9(1):491. doi: 10.1038/s41598-018-36858-3. PMID: 30679571;
PMCID: PMC6345753.

2018

Ali EH, Sharifpanah F, Taha A, Tsang SY, Wartenberg M, Sauer H. The Milk
Thistle (<i>Silybum marianum</i>) Compound Silibinin Inhibits Cardiomyogenesis
of Embryonic Stem Cells by Interfering with Angiotensin II Signaling. Stem Cells
Int. 2018 Dec 13;2018:9215792. doi: 10.1155/2018/9215792. PMID: 30651739; PMCID:
PMC6311720.

Sharifpanah F, Ali EH, Wartenberg M, Sauer H. The milk thistle (Silybum
marianum) compound Silibinin stimulates leukopoiesis from mouse embryonic stem
cells. Phytother Res. 2019 Feb;33(2):452-460. doi: 10.1002/ptr.6241. Epub 2018
Dec 11. PMID: 30548344.

Moreira P, Patel N, Wartenberg M, Li G, Tuncali K, Heffter T, Burdette EC,
Iordachita I, Fischer GS, Hata N, Tempany CM, Tokuda J. Evaluation of robot-
assisted MRI-guided prostate biopsy: needle path analysis during clinical
trials. Phys Med Biol. 2018 Oct 16;63(20):20NT02. doi: 10.1088/1361-6560/aae214.
PMID: 30226214; PMCID: PMC6198326.

Bekheit M, Audebert C, Bucur P, Adriaensen H, Bled E, Wartenberg M, Vignon-
Clementel I, Vibert E. Transit time ultrasound perivascular flow probe
technology is superior to MR imaging on hepatic blood flow measurement in a
porcine model. Hepatobiliary Pancreat Dis Int. 2018 Dec;17(6):538-545. doi:
10.1016/j.hbpd.2018.07.009. Epub 2018 Aug 8. PMID: 30170983.

Tber Z, Wartenberg M, Jacques JE, Roy V, Lecaille F, Warszycki D, Bojarski
AJ, Lalmanach G, Agrofoglio LA. Selective inhibition of human cathepsin S by
2,4,6-trisubstituted 1,3,5-triazine analogs. Bioorg Med Chem. 2018 Aug
7;26(14):4310-4319. doi: 10.1016/j.bmc.2018.07.032. Epub 2018 Jul 19. PMID:
30049585.

Wartenberg M, Schornak J, Gandomi K, Carvalho P, Nycz C, Patel N, Iordachita
I, Tempany C, Hata N, Tokuda J, Fischer GS. Closed-Loop Active Compensation for
Needle Deflection and Target Shift During Cooperatively Controlled Robotic
Needle Insertion. Ann Biomed Eng. 2018 Oct;46(10):1582-1594. doi:
10.1007/s10439-018-2070-2. Epub 2018 Jun 20. PMID: 29926303; PMCID: PMC6319385.

Wartenberg M, Cibin S, Zlobec I, Vassella E, Eppenberger-Castori S,
Terracciano L, Eichmann MD, Worni M, Gloor B, Perren A, Karamitopoulou E.
Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer
Reveals Three Distinct Subtypes with Prognostic/Predictive Significance. Clin
Cancer Res. 2018 Sep 15;24(18):4444-4454. doi: 10.1158/1078-0432.CCR-17-3401.
Epub 2018 Apr 16. PMID: 29661773.

Kasper B, Lecointe-Artzner E, Wait S, Boldon S, Wilson R, Gronchi A,
Valverde C, Eriksson M, Dumont S, Drove N, Kanli A, Wartenberg M. Working to
improve the management of sarcoma patients across Europe: a policy checklist.
BMC Cancer. 2018 Apr 16;18(1):424. doi: 10.1186/s12885-018-4320-y. PMID:
29661168; PMCID: PMC5902948.

Ali EH, Sharifpanah F, Wartenberg M, Sauer H. Silibinin from Silybum
marianum Stimulates Embryonic Stem Cell Vascular Differentiation via the
STAT3/PI3-K/AKT Axis and Nitric Oxide. Planta Med. 2018 Jul;84(11):768-778. doi:
10.1055/s-0044-100043. Epub 2018 Jan 12. PMID: 29329462.

Karamitopoulou E, Wartenberg M, Zlobec I, Cibin S, Worni M, Gloor B, Lugli
A. Tumour budding in pancreatic cancer revisited: validation of the ITBCC
scoring system. Histopathology. 2018 Jul;73(1):137-146. doi: 10.1111/his.13508.
Epub 2018 Apr 17. PMID: 29495092.

Galibert M, Wartenberg M, Lecaille F, Saidi A, Mavel S, Joulin-Giet A,
Korkmaz B, Brömme D, Aucagne V, Delmas AF, Lalmanach G. Substrate-derived
triazolo- and azapeptides as inhibitors of cathepsins K and S. Eur J Med Chem.
2018 Jan 20;144:201-210. doi: 10.1016/j.ejmech.2017.12.012. Epub 2017 Dec 7.
PMID: 29272750.

Jakob J, Gerres A, Ronellenfitsch U, Pilz L, Wartenberg M, Kasper B, Raab
HR, Hohenberger P. Behandlung retroperitonealer Sarkome in Deutschland : Eine
Umfrage der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie, der
Deutschen Interdisziplinären Studiengruppe Sarkome und der Patientenorganisation
Das Lebenshaus [Treatment of retroperitoneal sarcoma in Germany : Results of
a survey of the German Society of General and Visceral Surgery, the German
Interdisciplinary Sarcoma Study Group and the advocacy group Das Lebenshaus].
Chirurg. 2018 Jan;89(1):50-55. German. doi: 10.1007/s00104-017-0504-2. PMID:
28905080.