Herpes simplex virus type 1 and 2 resistance database

The Jena herpes simplex virus (HSV) resistance database provides a compilation of known nucleotide and amino acid substitutions of the HSV thymidine kinase (TK, ORF23) and polymerase (pol, ORF30) genes. Substitutions that are not associated with phenotypic resistance to any of the tested antivirals are considered as natural polymorphisms.

Sauerbrei A, Bohn-Wippert K, Kaspar M, Krumbholz A, Karrasch M, Zell R. 2016. Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.
J Antimicrob Chemother 71:6-16, doi: 10.1093/jac/dkv295, PMID: 26433780.

Last update: Feb. 2017

Thymidine kinase:

• Natural polymorphisms
  • HSV-1: Supplementary Table 1
  • HSV-2: Supplementary Table 2
• Resistance substitutions
  • HSV-1: Supplementary Table 3
  • HSV-2: Supplementary Table 4

DNA polymerase:

• Natural polymorphisms
  • HSV-1: Supplementary Table 5
  • HSV-2: Supplementary Table 6
• Resistance substitutions
  • HSV-1: Supplementary Table 7
  • HSV-2: Supplementary Table 8