Publikationen

Lossius C, Kresinsky A, Quiet L, Müller JP.
CRISPR/Cas9-Mediated Modification of PTP Expression
Methods Mol Biol. 2024;2743:43-56. doi: 10.1007/978-1-0716-3569-8_3.PMID: 38147207

Bauer R, Ringel J, Koch M, Laschke MW, Burkovski A, Karl M.
Design-Dependent Electrophysiological Effects of Electrolysis Electrodes Used for Endodontic Disinfection.
Appl. Sci. 2024, 14, 1445.

Zarca AM, Adlere I, Viciano CP, Arimont-Segura M, Meyrath M, Simon IA, Bebelman JP, Laan D, Custers HGJ, Janssen E, Versteegh KL, Buzink MCML, Nesheva DN, Bosma R, de Esch IJP, Vischer HF, Wijtmans M, Szpakowska M, Chevigné A, Hoffmann C, de Graaf C, Zarzycka BA, Windhorst AD, Smit MJ, Leurs R.
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3
Mol Pharmacol. 2024 Mar 14;105(4):301-312. doi: 10.1124/molpharm.123.000835.

Ay Ü; Leníček M; Haider R; Classen A; van Eijk H; Koelfat K; van der Kroft G; Neumann U; Hoffmann C; Bolm C; Olde Damink S; Schaap F.
Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR
Hepatol Commun. 8(4):e0383, April 2024. | DOI: 10.1097/HC9.0000000000000383

Gimeno-Ferrer F, Eitner A, Noora N, Bauer R, Schmidt-Hieber C, Schaible HG, Richter F.
Neuropathological changes in the TASTPM mouse model of Alzheimer's disease and their relation to hyperexcitability and cortical spreading depolarization.
Sci Rep. 2024 Mar 27;14(1):7224. doi: 10.1038/s41598-024-57868-4.

Ziegler AC, Haider RS, Hoffmann C, Gräler MH.
S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
Biomed Pharmacother. 2024 May:174:116575. doi: 10.1016/j.biopha.2024.116575. Epub 2024 Apr 9.

Blum NK, Schaffner A, Drube J, Nagel F, Reinscheid RK, Hoffmann C, Schulz S.
Rapid elucidation of agonist-driven regulation of the neurokinin 1 receptor using a GPCR phosphorylation immunoassay
Eur J Pharmacol. 2024 Jun 15:973:176587. doi: 10.1016/j.ejphar.2024.176587. Epub 2024 Apr 19.

Helbing DL, Haas F, Cirri E, Rahnis N, Dau TTD, Kelmer Sacramento E, Oraha N, Böhm L, Lajqi T, Fehringer P, Morrison H, Bauer R.
Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury
Front Immunol. 2024 Apr 9:15:1227355. doi: 10.3389/fimmu.2024.1227355. eCollection 2024.

Matthees ESF, Filor JC,  Jaiswal N, Reichel M, Youssef N, D'Uonnolo G, Szpakowska M, Drube J,  König GM, Kostenis E, Chevigné A, Godbole A, Hoffmann C.
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism
Commun Biol. 2024 Jul 3;7(1):802. doi: 10.1038/s42003-024-06490-1.

Matthees ESF, Hoffmann C.
The Ca2+-sensing receptor and the pocketome: comparing nature’s complexity with human intervention in receptor modulation
Signal Transduct Target Ther. 2024 Jul 15;9(1):173. doi: 10.1038/s41392-024-01863-8.

Underwood O, Fritzwanker S, Gleen J, Blum NK, Batista-Gondin A, Drube J, Hoffmann C, Briddon SJ, Schulz S, Canals M.
Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited
Commun Biol. 2024 Aug 2;7(1):933. doi: 10.1038/s42003-024-06571-1.

Liu N, Sonawane M, Sommerfeld O, Svensson CM, Figge MT, Bauer R, Bischoff SJ, Bauer M, Osuchowski MF, Press AT.
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
Front Immunol. 2024 Aug 30:15:1432307. doi: 10.3389/fimmu.2024.1432307. eCollection 2024.

Matthees ESF, Haider RS, Klement L, Reichel M, Blum NK, Weitzel V, Trüpschuch T, Ziegler C, Drube J, Schulz S, Hoffmann C.
Relating GPCR domains with functionality: receptor helix-bundle and C-terminus differentially influence GRK-specific functions and β-arrestin-mediated regulation
bioRxiv preprint doi: https://doi.org/10.1101/2024.09.30.615794

Bauer R.
Largely ignored-but pathogenetically significant: ambient temperature in rodent sepsis models
Intensive Care Med Exp. 2024 Nov 14;12(1):104. doi: 10.1186/s40635-024-00693-w.

Gerhards J, Maerz LD, Matthees ESF, Donow C, Moepps B, Premont RT, Burkhalter MD, Hoffmann C, Philipp M.
Kinase Activity Is Not Required for G Protein–Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development
J Am Soc Nephrol. 2023 Apr 1;34(4):590-606. doi: 10.1681/ASN.0000000000000082. Epub 2023 Jan 26.

Matera C, Kauk M, Cirillo D, Maspero M, Papotto C, Volpato D, Holzgrabe U, De Amici M, Hoffmann C, Dallanoce C.
Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis and FRET Investigation
Molecules. 2023 Mar 6;28(5):2407. doi: 10.3390/molecules28052407.

Lajqi T, Kostlin-Gille N, Bauer R, Zarogiannis SG, Lajqi E, Ajeti V, Dietz S, Kranig SA, Ruhle J, Demaj A, Hebel J, Bartosova M, Frommhold D, Hudalla H, Gille C.
Training vs. Tolerance: The Yin/Yang of the Innate Immune System
Biomedicines. 2023 Mar 2;11(3):766. doi: 10.3390/biomedicines11030766.

Heinz CS, Bermudez M, Jaiswal N,. Große C, Kauk M, Hoffmann C, Holzgabe U.
Hybridization into a Bitopic Ligand Increased Muscarinic Receptor Activation for Isopilocarpine but Not for Pilocarpine Derivatives
J Nat Prod. 2023 Apr 28;86(4):869-881. doi: 10.1021/acs.jnatprod.2c01079. Epub 2023 Apr 12.

Grimes J, Koszegi Z, Lanoiselée Y, Miljus T,  O'Brien SL, Stepniewski TM, Medel-Lacruz B, Baidya M, Makarova M, Mistry R, Goulding J, Drube J, Hoffmann C, Owen DM, Shukla AK, Selent J, Hill SJ, Calebiro D.
Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Cell. 2023 May 11;186(10):2238-2255.e20. doi: 10.1016/j.cell.2023.04.018. Epub 2023 May 4.

Haider RS, Reichel M, Matthees ESF, Hoffmann C.
Conformational flexibility of β-arrestins - How these scaffolding proteins guide and transform the functionality of GPCRs.
Bioessays. 2023 Aug;45(8):e2300053. doi: 10.1002/bies.202300053. Epub 2023 May 31.

Frasch MG , Yoon B-J , Helbing DL, Snir G, Antonelli MC, Bauer R.
Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.
Biology 2023, 12, 914

Gimeno-Ferrer F, Eitner A, Bauer R, Lehmenkühler A, Schaible HG, Richter F.
Cortical spreading depolarization is a potential target for rat brain excitability modulation by Galanin.
Exp Neurol. 2023 Dec:370:114569. doi: 10.1016. Epub 2023 Oct 10.

Ganguly A, Quon T, Jenkins L, Joseph B, Al-Awar R, Chevigne A, Tobin AB, Uehling DE, Hoffmann C, Drube J, Milligan G.
G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions
J Biol Chem. 2023 Oct;299(10):105218. doi: 10.1016/j.jbc.2023.105218. Epub 2023 Sep 1.

Burghi V, Paradis JS, Officer A, Adame Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS.
Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor
J Biol Chem. 2023 Nov;299(11):105293. doi: 10.1016/j.jbc.2023.105293. Epub 2023 Sep 27.

Sánchez-Soto M, Boldizsar NM, Schardien KA, Madaras NS, Willette BKA, Inbody LR, Dasaro C, Moritz AE, Drube J, Haider RS, Free RB, Hoffman C, Sibley DR.
G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation
Biomolecules. 2023 Oct 20;13(10):1552. doi: 10.3390/biom13101552.

Klement L, Drube J.
The interplay of FLT3 and CXCR4 in acute myeloid leukemia: an ongoing debate
Front Oncol. 2023 Oct 2:13:1258679. doi: 10.3389/fonc.2023.1258679. eCollection 2023.

Helbing DL , Kirkpatrick JM , Reuter M , Bischoff J , Stockdale A , Carlstedt A , Cirri E , Bauer R , Morrison H.
Proteomic analysis of peripheral nerve myelin during murine aging. 
Front. Cell. Neurosci. 2023, 17. doi: 10.3389/fncel.2023.1214003

Ravn-Boess N, Roy N, Hattori T, Bready D, Donaldson H, Lawson C, Lapierre C, Korman A, Rodrick T, Liu E, Frenster JD, Stephan G, Wilcox J, Corrado AD, Cai J, Ronnen R, Wang S, Haddock S, Ortiz JS, Mishkit O, Khodadadi-Jamayran A, Tsirigos A, Fenyö D, Zagzag D, Drube J, Hoffmann C, Perna F, Jones DR, Possemato R, Koide A, Koide S, Park CY, Placantonakis DG.
The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
Cell Rep. 2023 Nov 28;42(11):113374. doi: 10.1016/j.celrep.2023.113374. Epub 2023 Nov 8.

Kostenis E, Gomeza J, Miess-Tanneberg E, Blum NK, Benkel T, Chevigné A, Hoffmann C, Kolb P, Nikolaev V, Waldhoer M, Szpakowska M, Inoue A, Schulz S.
Reply to: How carvedilol does not activate β2-adrenoceptors
Nature Communications volume 14, Article number: 7867 (2023) Published: 30 November 2023

Maduabuchi WO, Tansi FL, Heller R. Hilger I.
Hyperthermia Influences the Secretion Signature of Tumor Cells and Affects Endothelial Cell Sprouting
Biomedicines. 2023 Aug 12;11(8):2256. doi: 10.3390/biomedicines11082256.

Doshi H, Spengler K, Godbole A, Gee YS, Baell J, Oakhill JS, Henke A, Heller R.
AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
Microbiol Spectr. 2023 Sep 13;11(5):e0041723. doi: 10.1128/spectrum.00417-23. Online ahead of print.

Szymanski L, Skopek R, Palusinska M, Maslinska-Gromadka K, Kraj L, Schenk T, Zelent A.
Epigenetic Modulation Enhances the Therapeutic Potential of All-Trans Retinoic Acid in Acute Myeloid Leukemia
Online Publication Only 802.Chemical Biology and Experimental Therapeutics, Volume 142, Supplement 1, 2 November 2023, Page 7141. doi.org/10.1182/blood-2023-174217

Sbirkov Y, Vergov B, Dzharov V, Schenk T, Petrie K, Sarafian V.
Targeting Glutaminolysis Shows Efficacy in Both Prednisolone-Sensitive and in Metabolically Rewired Prednisolone-Resistant B-Cell Childhood Acute Lymphoblastic Leukaemia Cells
Int J Mol Sci. 2023 Feb 8;24(4):3378. doi: 10.3390/ijms24043378.

Skopek R, Palusińska M, Kaczor-Keller K, Pingwara R, Papierniak-Wyglądała A, Schenk T, Lewicki S, Zelent A, Szymański L.
Choosing the Right Cell Line for Acute Myeloid Leukemia (AML) Research
Review Int J Mol Sci. 2023 Mar 11;24(6):5377. doi: 10.3390/ijms24065377.

Szymanski L, Skopek R, Palusinska M, Maslinska-Gromadka K, Kraj L, Schenk T, Zelent A.
Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
Front Cell Dev Biol. 2023 Mar 23:11:1076458. doi: 10.3389/fcell.2023.1076458. eCollection 2023.

Thévenin D, Müller JP.
Protein Tyrosine Phosphatases
Humana New York, NY, Hardcover ISBN978-1-0716-3568-1, 27 December 2023.

Reichel M, Weitzel V, Klement L, Hoffmann C, Drube J.
Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots
Int. J. Mol. Sci. 2022, 23(3), 1195. doi.org/10.3390/ijms23031195

Helbing DL, Böhm L, Oraha N, Stabenow LK, Cui Y.
A Ponceau S Staining-Based Dot Blot Assay for Rapid Protein Quantification of Biological Samples
Gels 8  2022 Jan 7;8(1):43. doi: 10.3390/gels8010043.

Drube J, Haider RS, Matthees ESF, Reichel M, Zeiner J, Fritzwanker S, Ziegler C, Barz S, Klement L, Filor J, Weitzel V, Kliewer A, Miess-Tanneberg E, Kostenis E, Schulz S, Hoffmann C.
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation.
Nat Commun. 2022 Jan 27;13(1):540. doi: 10.1038/s41467-022-28152-8.

Mayerl S, Martin AA, Bauer R, Schwanninger M, Heuer H, Ffrench-Constant C.
Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis.
Cells 2022, 11, 524. doi: 10.3390/cells11030524.

Kuldyushev N, Schönherr R, Coburger I, Ahmed M, Hussein RA, Wiesel E, Godbole A, Pfirrmann T, Hoshi T, Heinemann SH.
A GFP-based ratiometric sensor for cellular methionine oxidation.
Talanta. 2022 Jun 1;243:123332. doi: 10.1016/j.talanta.2022.123332. Epub 2022 Mar 3.

Demircan MB, Mgbecheta PC, Kresinsky A, Schnoeder TM, Schröder K, Heidel FH, Böhmer FD.
Combined Activity of the Redox-Modulating Compound Setanaxib (GKT137831) with Cytotoxic Agents in the Killing of Acute Myeloid Leukemia Cells.
Antioxidants. 2022 Mar 8;11(3):513. doi: 10.3390/antiox11030513.

Demircan MB, Schnoeder TM, Mgbecheta PC, Schröder K, Böhmer FD, Heidel FH.
Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML).
J Cancer Res Clin Oncol. 2022 Aug;148(8):1983-1990. doi: 10.1007/s00432-022-03986-3. Epub 2022 Mar 29.

Ovens AJ, Gee YS, Ling NXY, Yu D, Hardee JP, Chung JD, Ngoei KRW, Waters NJ, Hoffman NJ, Scott JW, Loh K, Spengler K, Heller R, Parker MW, Lynch GS, Huang F, Galic S, Kemp BE, Baell JB, Oakhill JS, Langendorf CG
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.
Biochem J. 2022 Jun 17;479(11):1181-1204. doi: 10.1042/BCJ20220067. 

Jungwirth J, Häring C, König S, Giebeler L, Doshi H, Brandt C, Deinhardt-Emmer S, Löffler B, Ehrhardt C.
D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir.
Int J Mol Sci. 2022 Jun 21;23(13):6880. doi: 10.3390/ijms23136880. 

Gimeno-Ferrer F, Eitner A, Bauer R, Lehmenkuhler A, Edenhofer ML, Kress M, Schaible HG, Richter F.
From spreading depolarization to epilepsy with neuroinflammation: The role of CGRP in cortex
Exp Neurol. 2022 Oct;356:114152. doi: 10.1016/j.expneurol.2022.114152. Epub 2022 Jun 26.

Helbing DL, Stabenow LK, Bauer R.
Mouse sepsis models: don't forget ambient temperature!
Intensive Care Med Exp. 2022 Jul 1;10(1):29. doi: 10.1186/s40635-022-00457-4.

Stabenow LK, Zibrova D, Ender C, Helbing DL, Spengler K, Marx C, Wang ZQ, Heller R.
Oxidative Glucose Metabolism Promotes Senescence in Vascular Endothelial Cells.
Cells. 2022 Jul 16;11(14):2213. doi: 10.3390/cells11142213. PMID: 35883656; PMCID: PMC9322806.

Schacke S, Kirkpatrick J, Stocksdale A, Bauer R, Hagel C, Riecken LB, Morrison H.
Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype.
Glia. 2022 Dec;70(12):2309-2329. doi: 10.1002/glia.24253. Epub 2022 Aug 5.

Haider RS, Matthees ESF, Drube J, Reichel M, Zabel U, Inoue A, Chevigné A, Krasel C, Deupi X, Hoffmann C.
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells
Nat Commun. 2022 Sep 26;13(1):5638. doi: 10.1038/s41467-022-33307-8.

Voelker MT, Hechaichi N, Ndongson-Dongmo B, Lemm J, Heller R, Bauer R, Conway EM, Theilmeier G, Stehr SN.
Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy.
Life Sci. 2022 Oct 1;306:120830. doi: 10.1016/j.lfs.2022.120830. Epub 2022 Jul 21.

Schwarz M, Rizzo S, Espinoza Paz W, Kresinsky A, Thévenin D,  Müller JP.
Disrupting PTPRJ Transmembrane-Mediated Oligomerization Counteracts Oncogenic Receptor Tyrosine Kinase FLT3 ITD.
Front Oncol. 2022 Nov 14;12:1017947. doi: 10.3389/fonc.2022.1017947. eCollection 2022.

Kaufmann J, Blum NK, Nagel F, Schuler A, Drube J, Degenhart C, Engel J, Eickhoff JE, Dasgupta P, Fritzwanker S, Guastadisegni M,  Schulte C, Miess-Tanneberg E, Maric HM, Spetea M, Kliewer A, Baumann M, Klebl B, Reinscheid RK, Hoffmann C, Schulz S.
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening
Commun Biol. 2022 Nov 9;5(1):1206. doi: 10.1038/s42003-022-04135-9.

Benkel T, Zimmermann M, Zeiner J, Bravo S, Merten N, Lim VJY, Matthees ESF, Drube J, Miess-Tanneberg E, Malan D, Szpakowska M, Monteleone S, Grimes J, Koszegi Z, Lanoiselée Y, O'Brien S, Pavlaki N, Dobberstein N, Inoue A, Nikolaev V, Calebiro D, Chevigné A, Sasse P, Schulz S, Hoffmann C, Kolb P, Waldhoer M, Simon K, Gomeza J, Kostenis E.
How Carvedilol activates β2-adrenoceptors.
Nat Commun. 2022 Nov 19;13(1):7109. doi: 10.1038/s41467-022-34765-w.

Heiss J, Grun K, Tempel L, Matasci M, Schrepper A, Schwarzer, M, Bauer R, Forster M, Berndt A, Jung C, Schulze P C, Neri D, Franz M.
Targeted Interleukin-9 delivery in pulmonary hypertension: comparison of immunocytokine formats and effector cell study
Eur J Clin Invest. 2023 Mar;53(3):e13907. doi: 10.1111/eci.13907. Epub 2022 Nov 26.

Stengel S, Petrie KR, Sbirkov Y, Stanko C, Ghazvini Zadegan F, Gil V, Skopek R, Kamiński P, Szymański Ł, Brioli A, Zelent A, Schenk T.
Suppression of MYC by PI3K/AKT/mTOR pathway inhibition in combination with all-trans retinoic acid treatment for therapeutic gain in acute myeloid leukaemia
Br J Haematol. 2022 Jul;198(2):338-348. doi: 10.1111/bjh.18187.

Matthees ESF, Haider RS, Hoffmann C.
β-arrestin-based biosensors – tools to explore structural determinants of metabolic functions?
Current opinion of Endocrine and Metabolic Research. 2021;16:66-74. doi.org/10.1016/j.coemr.2020.09.006

Frasch MG, Walter B, Herry CL, Bauer R.
Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs
Sci Data. 2021 Jan 7;8(1):4. doi: 10.1038/s41597-020-00781-y.

Leonhardt J, Haider RS, Sponholz C, Leonhardt S, Drube J, Spengler K, Mihaylov D, Neugebauer S, Kiehntopf M, Lambert NA, Kortgen A, Bruns T, Tacke F, Hoffmann C, Bauer M, Heller R.
Circulating bile acids in liver failure activate TGR5 and induce monocyte dysfunction
Cell Mol Gastroenterol Hepatol. 2021; doi.org/10.1016/j.jcmgh.2021.01.011

Leitzke M, Schimpf S, Altrock M, Schönknecht P, Bischoff S, Schubert H, Hoyer D, Bauer R, Olbrich S.
Afferent vagal stimulation via gastric electrical stimulation alters sympathetic-vagal balance in domestic pigs - a pilot trial.
J Biol Regul Homeost Agents. 2021 Jan-Feb;35(1):11-24. doi: 10.23812/20-527-A.

Heinze K, Hölzer M, Ungelenk M, Gerth M, Thomale J, Heller R, Morden CR, McManus KJ, Mosig AS, Dürst M, Runnebaum IB, Häfner N.
RUNX3 Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis.
Cancers (Basel). 2021 Jan 26;13(3):476. doi: 10.3390/cancers13030476.

Lajqi T, Marx C, Hudalla H, Haas F, Große S, Wang Z-Q, Heller R, Bauer M, Wetzker R, and Bauer R.
The role of the pathogen dose and PI3Kγ in immunometabolic reprogramming of microglia for innate immune memory.
Int. J. Mol. Sci. 2021, 22(5), 2578; doi.org/10.3390/ijms22052578

Deinhardt-Emmer S, Böttcher S, Häring C, Giebeler L, Henke A, Zell R, Jungwirth J, Jordan PM, Werz O, Hornung F, Brandt C, Marquet M, Mosig AS, Pletz MW, Schacke M, Rödel J, Heller R, Nietzsche S, Löffler B, Ehrhardt C.
SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction.
J Virol. 2021 Apr 26;95(10):e00110-21. doi: 10.1128/JVI.00110-21. Epub 2021 Feb 26.

Matthees ESF, Haider RS, Hoffmann C, Drube J.
Differential Regulation of GPCRs—Are GRK Expression Levels the Key?
Front. Cell Dev. Biol., 24 May 2021, 9:687489; doi: 10.3389/fcell.2021.687489

Deinhardt-Emmer S, Jäckel L, Häring C, Böttcher S, Wilden JJ, Glück B, Heller R, Schmidtke M, Koch M, Löffler B, Ludwig S, Ehrhardt C.
Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice.
Biomolecules. 2021 May 29;11(6):808. doi: 10.3390/biom11060808. PMID: 34072389; PMCID: PMC8228449.

Press AT, Babic P, Hoffmann B, Muller T, Foo W, Hauswald W, Benecke J, Beretta M, Cseresnyes Z, Hoeppener S, Nischang, Coldewey SM, Graler MH, Bauer R, Gonnert F, Gassler N, Wetzker R, Figge MT, Schubert US, Bauer M.
Targeted delivery of a phosphoinositide 3-kinase gamma inhibitor to restore organ function in sepsis.
EMBO Mol Med. 2021 Oct 7;13(10):e14436. doi: 10.15252/emmm.202114436. Epub 2021 Sep 2

Frasch MG, Walter B, Anders Ch, Bauer R.
Update to the dataset of cerebral ischemia in juvenile pigs with evoked potentials.
Sci Data. 2021 8:248.

Schmidt C, Schneble-Löhnert N, Lajqi T,  Wetzker R, Müller JP, Bauer R.
PI3Kgamma mediates microglial proliferation and cell viability via ROS.
Cells. 2021, Sep 24;10(10):2534. doi: 10.3390/cells10102534

Di Sanzo S, Spengler K, Leheis A, Kirkpatrick JM, Rändler TL, Baldensperger T, Dau T, Henning C, Parca L, Marx C, Wang ZQ, Glomb MA, Ori A, Heller R.
Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation.
Nat Commun. 2021 Nov 18;12(1):6743. doi: 10.1038/s41467-021-26982-6. PMID: 34795246.

Mickoleit F, Jörke C, Geimer S, Maier DS, Müller JP, Demut J, Gräfe C, Schüler D, Clement JH.
Biocompatibility, uptake and subcellular localization of bacterial magnetosomes in mammalian cells.
Nanoscale Adv. 2021 May 22;3(13):3799-3815. doi: 10.1039/d0na01086c

Sbirkov Y, Ivanova T, Burnusuzov H, Gercheva K, Petrie K, Schenk T, Sarafian V
The Protozoan Inhibitor Atovaquone Affects Mitochondrial Respiration and Shows In Vitro Efficacy Against Glucocorticoid-Resistant Cells in Childhood B-Cell Acute Lymphoblastic Leukaemia.
Front Oncol. 2021 Mar 15;11:632181. doi: 10.3389/fonc.2021.632181.

Schütt J, Nägler T, Schenk T, Brioli A
Investigating the Interplay between Myeloma Cells and Bone Marrow Stromal Cells in the Development of Drug Resistance: Dissecting the Role of Epigenetic Modifications.
Cancers (Basel). 2021 Aug 13;13(16):4069. doi: 10.3390/cancers13164069.

Waldt N, Scharnetzki D, Kesseler C, Kirches E, Stroscher N, Böhmer FD, Mawrin C.
Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development
J Neurol Sci. 2020 Jan 15;408:116553. doi: 10.1016/j.jns.2019.116553. Epub 2019 Nov 9.

Graber K, Khan F, Glück B, Weigel C, Marzo S, Doshi H, Ehrhardt C, Heller R, Gräler M, Henke A.
The role of sphingosine-1-phosphate signaling in HSV-1-infected human umbilical vein endothelial cells.
Virus Res. 2020 Jan 15;276:197835. doi: 10.1016/j.virusres.2019.197835. Epub 2019 Dec 9.

Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G.
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Böhmer A, Barz S, Schwab K, Kolbe U, Gabel A, Kirkpatrick J, Ohlenschläger O, Görlach M, Böhmer FD.
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Butt E, Stempfle K, Lister L, Wolf F, Kraft M, Herrmann AB, Viciano CP, Weber C, Hochhaus A, Ernst T, Hoffmann C, Zernecke A, Frietsch JJ.
Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia.
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Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyés Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Löffler B, Mosig AS.
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Schubert M, Becher S, Wallert M, Maeß MB, Abhari M, Rennert K, Mosig AS, Große S, Heller R, Grün M, Lorkowski S.
The Peroxisome Proliferator-Activated Receptor (PPAR)-γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPARδ and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages.
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Spengler K, Kryeziu N, Große S, Mosig AS, Heller R.
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Herrmann AB, Müller ML, Orth MF, Müller JP, Zernecke A, Hochhaus A, Ernst T, Butt E, Frietsch JJ.
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Mühleder S, Fuchs Ch, Basilio J, Szwarc D, Pill K, Labuda K, Slezak P, Siehs Ch, Pröll J, Priglinger E, Hoffmann C, Junger W, Redl H, Holnthoner W.
Purinergic P2Y2 receptors modulate endothelial sprouting.
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Jeya Paul J, Weigel C, Müller T, Heller R, Spiegel S, Gräler MH.
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Schicke E, Cseresnyés Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S, Swiczak F, Schmidtke M, Glück B, Koch M, Schacke M, Heller R, Mosig AS, Figge MT, Ehrhardt C, Löffler B, Deinhardt-Emmer S.
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Kellner F, Keil A, Schindler K, Tschongov T, Hünninger K, Loercher H, Rhein P, Böhmer SA, Böhmer FD, Müller JP.
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Neves M, Perpina-Viciano C, Penela P, Hoffmann C, Mayor Jr F.
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ACS Pharmacol. Transl.Sci. 2020 Apr 27;3(4):627-634. doi: 10.1021/acsptsci.0c00021. eCollection 2020 Aug 14                    

Reich D, Kresinsky A, Müller JP, Bauer R, Kallenbach J, Schnoeder TM, Heidel FH, Fässler R, Mann M, Böhmer FD, Jayavelu AK.
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Leukemia. 2020 May;34(5):1444-1449. doi: 10.1038/s41375-019-0676-5. Epub 2019 Dec 13.        

Hemling P, Zibrova D, Strutz J, Sohrabi Y, Desoye G, Schulten H, Findeisen H, Heller R, Godfrey R, Waltenberger J.
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Helbing DL, Schulz A, Morrison H.
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Ludwig K, Husain RA, Rubio I.
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Kaiser A, Schmidt M, Huber O, Frietsch JJ, Scholl S, Heidel FH, Hochhaus A, Müller JP, Ernst T.
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Perpina-Viciano C, Isbilir A, Zarca A, Caspar B,  Kilpatrick LE, Hill SJ, Smit MJ, Lohse MJ, Hoffmann C.   
Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4
Mol Pharmacol. 2020 Aug;98(2):72-87. doi: 10.1124/mol.119.118448. Epub 2020 May 30.   

Beer AJ, Hertz D, Seemann E, Beretta M, Westermann M, Bauer R, Bauer M, Kessels MM, Qualmann B.   
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Holze J, Bermudez M, Pfeil EM, Kauk M, Bödefeld T, Irmen M, Matera C, Dallanoce C, De Amici M, Holzgrabe U, König GM, Tränkle C, Wolber G, Schrage R, Mohr K, Hoffmann C, Kostenis E, Bock A.
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Szymański L, Skopek R, Palusińska M, Schenk T, Stengel S, Lewicki S, Kraj L, Kamiński P, Zelent A.
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Spengler K, Zibrova D, Woods A, Langendorf CG, Scott JW, Carling D, Heller R.
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Lajqi T, Stojiljkovic M, Williams DL, Hudalla H, Bauer M, Witte OW, Wetzker R, Bauer R. and Schmeer C.
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Lang GP, Ndongson-Dongmo B, Lajqi T, Brodhun M, Han Y, Wetzker R, Frasch MG, Bauer R.
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Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ.
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists
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Volpato D, Kauk M, Messerer R, Bermudez M, Wolber G, Bock A, Hoffmann C, Holzgrabe U.
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Adlere I, Sun S, Zarca A, Roumen L, Gozelle M, Viciano Perpiñá C, Caspar B, Arimont M, Bebelman JP, Briddon SJ5, Hoffmann C, Hill SJ, Smit MJ, Vischer HF, Wijtmans M, de Graaf C, de Esch IJP, Leurs R.
Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.
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Haider RS, Wilhelm F, Rizk A, Mutt E, Deupi X, Peterhans C, Mühle J, Berger P, Schertler GFX, Standfuss J, Ostermaier MK.
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Kresinsky A, Schnöder TM, Jacobsen ID, Rauner M, Hofbauer LC, Ast V, König R, Hoffmann B, Svensson CM, Figge MT, Hilger I, Heidel FH, Böhmer FD, Müller JP.
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Harnoš J, Cañizal MCA, Jurásek M, Kumar J, Holler C, Schambony A, Hanáková K, Bernatík O, Zdráhal Z, Gömöryová K, Gybeľ T, Radaszkiewicz TW, Kravec M, Trantírek L0, Ryneš J, Dave Z, Fernández-Llamazares AI, Vácha R, Tripsianes K, Hoffmann C, Bryja V.
Dishevelled-3 protein conformation dynamics analyzed by FRET-based biosensors: a key role of casein kinase 1
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Ndongson-Dongmo B, Lang GP, Mece O, Hechaichi N, Lajqi T, Hoyer D, Brodhun M, Heller R, Wetzker R, Franz M, Levy FO, Bauer R.
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Heuninck J, Perpina Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C.
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Rohm I, Grün K, Müller LM, Bäz L, Förster M, Schrepper A, Kretzschmar D, Pistulli R, Yilmaz A, Bauer R, Jung C, Berndt A, Schulze PC, Franz M.
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Arimont M, Hoffmann C, de Graaf C, Leurs R.
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Kahl M, Brioli A, Bens M, Perner F, Kresinsky A, Schnetzke U, Hinze A, Sbirkov Y, Stengel S, Simonetti G, Martinelli G, Petrie K, Zelent A, Böhmer FD, Groth M, Ernst T, Heidel FH, Scholl S, Hochhaus A, Schenk T.
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Burczyk MS, Burkhalter MD, Tena TC, Grisanti LA, Kauk M, Matysik S, Donow C, Kustermann M, Rothe M, Cui Y, Raad F, Laue S, Moretti A, Zimmermann WH, Wess J, Kühl M, Hoffmann C, Tilley DG, Philipp M.
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Lajqi T, Lang GP, Haas F, Williams DL, Hudalla H, Bauer M, Groth M, Wetzker R and Bauer R.
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Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos Y Schnitzler M.
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Balakrishnan P, Liebe T, Amro E, Dhaka L, Heinzel T, Heller R.
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Drube J, Ernst T, Pfirrmann M, Albert BV, Drube S, Reich D, Kresinsky A, Halfter K, Sorio C, Fabisch C, Hochhaus A, Böhmer FD.
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Kauk M, Hoffmann C.
Intramolecular and Intermolecular FRET Sensors for GPCRs - Monitoring Conformational Changes and Beyond.
Trends Pharmacol Sci. 2018 Feb;39(2):123-135. doi: 10.1016/j.tips.2017.10.011. 

Spengler K, Große S, Kryeziu N, Knierim A, Heller R.
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Schreiber B, Kauk M, Heil H, Emmerling M, Tesmer I, Kamp M, Höfling S, Holzgrabe U, Hoffmann C, Heinze K. 
Enhanced fluorescence resonance energy transfer in G-protein-coupled receptor probes by nano-coated microscopy coverslips.
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Calebiro D, Godbole A.
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Zilch A, Rien C, Weigel C, Huskobla S, Glück B, Spengler K, Sauerbrei A, Heller R, Gräler M, Henke A.
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Dorenkamp M, Müller JP, Shanmuganathan KS, Schulten H, Müller N, Löffler I, Müller UA, Wolf G, Böhmer FD, Godfrey R, Waltenberger J.
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Littmann T, Ozawa T, Hoffmann C, Buschauer A, Bernhardt G.
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Kresinsky A, Bauer R, Schnöder TM, Berg T, Meyer D, Ast V, König R, Serve H, Heidel FH, Böhmer FD, Müller JP.
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Buttner R, Schulz A, Reuter M, Akula AK, Mindos T, Carlstedt A, Riecken LB, Baader SL, Bauer R, Morrison H.
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Leonhardt J, Große S, Marx C , Siwczak F, Stengel S, Bruns T, Bauer R, Kiehntopf M, Williams DL, Wang ZQ, Mosig AS, Weis S, Bauer M, Heller R.
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Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R.
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Tsitsipatis D, Jayavelu AK, Muller JP, Bauer R, Schmidt-Arras D, Mahboobi S, Schnoder TM, Heidel F, Bohmer FD.
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Borken F, Markwart R, Requardt RP, Schubert K, Spacek M, Verner M, Rückriem S, Scherag A, Oehmichen F, Brunkhorst FM, Rubio I.
Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response.
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Mai M, Stengel S, Al-Herwi E, Peter J, Schmidt C, Rubio I, Stallmach A, Bruns T.
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Jung C, Grun K, Betge S, Pernow J, Kelm M, Muessig J, Masyuk M, Kuethe F, Ndongson-Dongmo B, Bauer R, Lauten A, Schulze PC, Berndt A, Franz M.
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Geißler K, Markwart R, Requardt RP, Weigel C, Schubert K, Scherag A, Rubio I, Guntinas-Lichius O.
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Rinke J, Müller JP, Blaess MF, Chase A, Meggendorfer M, Schäfer V, Winkelmann N, Haferlach C, Cross NCP, Hochhaus A, Ernst T.
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Lipedema – lack of evidence for the involvement of tyrosine kinases.
J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):161-3

Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A. 
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.   
Sci Transl Med. 2016 Jan 13;8(321):321ra7

Jayavelu AK, Müller JP, Bauer R, Böhmer SA, Lässig J, Cerny-Reiterer S, Sperr WR, Valent P, Maurer B, Moriggl R, Schröder K, Shah AM, Fischer M, Scholl S, Barth J, Oellerich T, Berg T, Serve H, Frey S, Fischer T, Heidel FH, Böhmer FD.
NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.
Leukemia. 2016 Feb;30(2):473-83.

Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I.
Feedback activation of neurofibromin terminates growth factor-induced Ras activation. 
Cell Commun Signal. 2016 Feb 9;14(1):5

Njeru J, Henning K, Pletz MW, Heller R, Neubauer H.
Q fever is an old and neglected zoonotic disease in Kenya: a systematic review
BMC Public Health. 2016 Apr 5;16:297. doi: 10.1186/s12889-016-2929-9.

Gürke J, Schindler M, Pendzialek SM, Thieme R, Grybel KJ, Heller R, Spengler K, Fleming TP, Fischer B, Navarrete Santos A.
Maternal diabetes promotes mTORC1 downstream signalling in rabbit preimplantation embryos
Reproduction. 2016 May;151(5):465-76. doi: 10.1530/REP-15-0523. Epub 2016 Feb 1.

Njeru J, Henning K, Pletz MW, Heller R, Forstner C, Kariuki S, Fèvre EM.
Febrile patients admitted to remote hospitals in Northeastern Kenya:seroprevalence, risk factors and a clinical prediction tool for Q-Fever.
BMC Infect Dis. 2016 Jun 3;16:244. doi: 10.1186/s12879-016-1569-0.

Koch S, Helbing I, Böhmer SA, Hayashi M, Claesson-Welsh L, Söderberg O, Böhmer FD.
In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions.
Methods Mol Biol. 2016;1447:217-42.

Mußbach F, Ungefroren H, Günther B, Katenkamp K, Henklein P, Westermann M, Settmacher U, Lenk L, Sebens S, Müller JP, Böhmer FD, Kaufmann R.
Proteinase-activated receptor 2 (PAR2) in hepatic stellate cells - evidence for a role in hepatocellular carcinoma growth in vivo.
Mol Cancer. 2016 Jul 29;15(1):54. doi: 10.1186/s12943-016-0538-y.

Schmidt C, Frahm C, Schneble N, Muller JP, Brodhun M, Franco I, Witte OW, Hirsch E, Wetzker R, Bauer R.
Phosphoinositide 3-Kinase γ restrains neurotoxic effects of microglia after focal brain ischemia.
Molecular neurobiology. 2016 Oct; 53 (8):5468-5479. doi:10.1007/s12035-015-9472-z

Pai GM, Zielinski A, Koalick D, Ludwig K, Wang ZQ, Borgmann K, Pospiech H, Rubio I
TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.
Oncotarget. 2016 Dec 20;7(51):85365-85380. doi: 10.18632/oncotarget.13378.

Gottlieb-Abraham E, Gutman O, Pai GM, Rubio I, Henis YI.
The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions.
Mol Biol Cell. 2016 Dec 1;27(24):3926-3936.

Schulz A, Buttner R, Toledo A, Baader SL, von Maltzahn J, Irintchev A, Bauer R, Morrison H.
Neuron-specific deletion of the Nf2 tumor suppressor impairs functional nerve regeneration.
PLoS One. 2016 Juli 28; 11(7):e0159718. doi: 10.1371/journal.pone.0159718. eCollection 2016.

Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP.
RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines
Oncogene. 2016 Jul 14;35(28):3658-68. doi: 10.1038/onc.2015.431.

Njeru J, Wareth G, Melzer F, Henning K, Pletz MW, Heller R, Neubauer H.
Systematic review of brucellosis in Kenya: disease frequency in humans and animals and risk factors for human infection.
BMC Public Health. 2016 Aug 22;16(1):853. doi: 10.1186/s12889-016-3532-9

Schmidt C, Frahm C, Schneble N, Muller JP, Brodhun M, Franco I, Witte OW, Hirsch E, Wetzker R, Bauer R.
Phosphoinositide 3-Kinase γ restrains neurotoxic effects of microglia after focal brain ischemia.
Mol neurobiol. 2016 Oct;53(8):5468-79. doi: 10.1007/s12035-015-9472-z.

von Loeffelholz C, Horn P, Birkenfeld AL, Claus RA, Metzing BU, Döcke S, Jahreis G, Heller R, Hoppe S, Stockmann M, Lock JF, Rieger A, Weickert MO, Settmacher U, Rauchfuß F, Pfeiffer AF, Bauer M, Sponholz C.
Fetuin A is a Predictor of Liver Fat in Preoperative Patients with Nonalcoholic Fatty Liver Disease.
J Invest Surg. 2016 Oct;29(5):266-74. doi: 10.3109/08941939.2016.1149640.

Bloch L, Ndongson-Dongmo B, Kusch A, Dragun D, Heller R, Huber O.
Real-time monitoring of hypertrophy in HL-1 cardiomyocytes by impedance measurements reveals different modes of growth.
Cytotechnology. 2016 Oct;68(5):1897-907. doi: 10.1007/s10616-016-0001-3.

Franz M, Grün K, Betge S, Rohm I, Ndongson-Dongmo B, Bauer R, Schulze PC, Lichtenauer M, Petersen I, Neri D, Berndt A, Jung C.
Lung tissue remodelling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression.
Oncotarget. 2016 Dec 6;  7(49):81241-81254. doi: 10.18632/oncotarget.13220

Kresinsky A, Schneble N, Schmidt C, Frister A, Bauer R, Wetzker R, Müller JP.
Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase γ.
Immunol Lett. 2016 Dec; 180:9-16. doi: 10.1016/j.imlet.2016.09.014.

Njeru J, Melzer F, Wareth G, El-Adawy H, Henning K, Pletz MW.
Human Brucellosis in Febrile Patients Seeking Treatment at Remote Hospitals, Northeastern Kenya, 2014-2015.
Emerg Infect Dis. 2016 Dec; 22(12):2160-2164. doi: 10.3201/eid2212.160285.

Jayavelu AK, Moloney JN, Böhmer FD, Cotter TG.
NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML.
Exp Hematol. 2016 Dec; 44(12):1113-1122. doi: 10.1016/j.exphem.2016.08.008.

Inhalt

Biskup C, Rubio I
Real-time visualization and quantification of native Ras activation in single living cells.
Meth Mol Biol. 2014;1120:285-305

Augsten M, Böttcher A, Spanbroek R, Rubio I, Friedrich K
Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains.
Cell Commun Signal. 2014 Jan 2;12(1):1. doi: 10.1186/1478-811X-12-1.

Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
J Clin Invest 2014; May 1;124(5):1987-99

Schulz A, Walther C, Morrison H, Bauer, R
In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves.
J. Vis. Exp. 2014 86: e51181, doi:10.3791/51181

Donat CK,Fischer F, Walter B, Deuther-Conrad W, Brodhun M, Bauer R, Brust P
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet.
Acta Neurobiol Exp (Wars). 2014;74(2):197-210

Wilisch-Neumann A, Pachow D, Wallesch M, Petermann A, Böhmer FD, Kirches E, Mawrin C
Re-evaluation of cytostatic therapies for meningiomas in vitro.
J Cancer Res Clin Oncol. 2014 Aug;140(8):1343-52

Böhmer FD, Friedrich K
Protein tyrosine phosphatases as wardens of STAT signaling.
JAKSTAT. 2014 Jan 1;3(1):e28087. Epub 2014 Feb 20. Review

Frister A, Schmidt C, Schneble N, Brodhun M, Gonnert FA, Bauer M, Hirsch E, Müller JP, Wetzker R,   Bauer R
Phosphoinositide 3-kinase gamma affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells. 
NeuroMolecular Med. 2014 Dec;16(4):704-13

Markwart R, Condotta SA, Requardt RP, Borken F, Schubert K, Weigel C, Bauer M, Griffith TS, Förster M, Brunkhorst FM, Badovinac VP, Rubio I
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.    
PLoS One. 2014 Dec 26;9(12)

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R
PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.
Br J Pharmacol. 2014 171, 3328-37

Hofmann C, Stühmer T, Schmiedl N, Wetzker R, Mottok A, Rosenwald A, Langer C, Zovko J, Chatterjee M, Einsele H, Bargou RC, Steinbrunn T
PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.
Br J Haematol. 2014; 166, 529-39 (2014)

Schmidt C, Schneble N, Wetzker R
The fifth dimension of innate immunity.
J Cell Commun Signal. 2014; 8, 363-7

Perino A, Beretta M, Kilić A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E
Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.
Sci Signal. 2014; 7 Nov 18 (352) ra110

Kühnl A, Rien C, Spengler K, Kryeziu N, Sauerbrei A, Heller R, Henke A
Characterization of coxsackievirus B3 replication in human umbilical vein endothelial cells.
Med Microbiol Immunol. 2014; Aug;203(4):217-29

Skorokhod OA, Barrera V, Heller R, Carta F, Turrini F, Arese P, Schwarzer E
Malarial pigment hemozoin impairs chemotactic motility and transendothelial migration of monocytes via 4-hydroxynonenal.
Free Radic Biol Med. 2014; 75; 210-21

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